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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 3 | Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation显示文摘 | Jose A. Rodríguez-Navarro Laura Rodríguez María J. Casarejos Rosa M. Solano Ana Gómez Juan Perucho Ana María Cuervo Justo García de Yébenes María A. Mena | 2010 | Neurobiology of Disease2010，，3： | 2 |
| 4 | Comparison of commercial solid acid catalysts for the esterification of acetic acid with butanol 显示文摘 | Peters T A Benes N E Holmen A | 2006 | Applied Catalysis A : General2006，297，2： | 1 |
| 5 | 5 polymorphisms in the transforming growth factor-beta 1 gene (TGF-beta 1) in adult periodontitis 显示文摘 | Holla L I Fassmann A Benes P | 2002 | J Clin Periodontol2002，29，4： | 1 |
| 6 | The MIQE guide- lines: Minimum information for publication of quantita- tive real-time PCR experiments显示文摘 | Bustin S A Benes V Garson J A | 2009 | Clin Chem2009，55，4： | 1 |
| 7 | Progressive lacunar stroke : Re- view of mechanisms, prognostic features, and putative treatments显示文摘 | Del Bene A Palumbo V Lamassa M | 2012 | Int JStroke2012，7，4： | 1 |
| 8 | Dynamics of gene expression revealed by comparison of serial analysis of gene expression transcript profiles from yeast grown on two different carbon sources 显示文摘 | Kal A J Van Zonneveld A J Benes V | 1999 | Mol Biol Cell1999，10，6： | 1 |
| 9 | Two-bond ^19F-^15N spin-spin coupling constants (^2hJF-N) across F-H……N hydrogen bonds显示文摘 | Del Bene J E Perera S A Rodney J | 2003 | J Phys Chem A2003，107，： | 1 |
| 10 | Quantitative real-time RT-PCR a perspective显示文摘 | Bustin S A Benes V Nolan T Pfaffl M W | 2005 | Journal of Molecular Endocrinology2005，34，： | 1 |
| 11 | Quantitative realtime RT-PCR-a perspective显示文摘 | BUSTIN S A BENES V NOLAN T | 2005 | Journal of Molecular Endocrinology2005，34，： | 1 |
| 12 | Is type 2 dia- betes related to leukoaraiosis? An updated review 显示文摘 | Del Bene A Ciolli L Borgheresi L | 2015 | Aeta Neurol Scand2015，132，3： | 1 |
| 13 | The MIQE guidelines: minimum information for publication of quantitative real-tlme PCR experiments 显示文摘 | Bustin S A Benes V Garson J A | 2009 | Clin Chem2009，55，4： | 1 |
| 14 | The MIQE guidelines:minimum information for publication of quantitative real-time PCR experiments显示文摘 | BUSTIN S A BENES V GARSON J A | 2009 | Clin Chem2009，55，4： | 1 |
| 15 | Blood and urinelevels of Pb, Cd and Hg in the general population o{ the Czech Republic and proposed reference values显示文摘 | Batdariovd A Spevdckov6 V Benes B eta | 2006 | Int J Hyg Environ Health2006，209，4： | 1 |
| 16 | The MIQE guidelines:minimum information for publication of quantitative real-time PCR experiments显示文摘 | BUSTIN S A BENES V GARSON J A | 2009 | Clin Chem2009，55，4： | 1 |
| 17 | The MIQE guidelines:min imum information for publication of quantitative real-time PCR experiments显示文摘 | Bustin S A Benes V Garson J A | 2009 | Clin Chem2009，55，4： | 1 |
| 18 | Primer sequence disclosure : a clarification of the MIQE guidehnes 显示文摘 | Bustin S A Benes V Garson J A | 2011 | Clin Chem2011，57，6： | 1 |
| 19 | Up - regulation of GABAA receptor binding on neurons of the prefrontal cortex in schizophrenic subject 显示文摘 | Benes FM Vincent SL Marie A | 1996 | Neuroscience1996，75，： | 1 |
| 20 | Soil respiration: implications of the plant-soil continuum and respiration chamber collar-insertion depth on measurement and modeling of soil C02 efflux rates in three ecosystems 显示文摘 | Heinemeyer A Di Bene C Lloyd A R | 2011 | European Journal of Soil Science2011，62，1： | 1 |
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