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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 3 | The determination of evaporation from land and water surfaces显示文摘 | Thornthwaite C W Benjamin Holzman | 1939 | Monthly Weather Review1939，67，1： | 1 |
| 4 | Promising new developments in cancer chemotheraty显示文摘 | Benjamine W Renzo C | 1999 | Cancer Chemother Pharmacol1999，，： | 1 |
| 5 | Basic fibroblast growth factor-induced cell death is effected through sustained activation of p38MAPK and up-regulation of the death receptor p75NTR显示文摘 | Andrew J K W Benjamin C D James R B | 2004 | J Biol Chem2004，279，47： | 1 |
| 6 | Retail leasing:the determinants of shopping center rents显示文摘 | Benjamin J D Boyal G W Sirmans C F | 1990 | Journal of the American Real Estate and Urban Economics Association1990，，： | 1 |
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| 8 | Characterizing acrylic foam pressure sensitive adhesive tapes for structural glazing applications--Part I:DMA and ramp-to-fail results显示文摘 | Benjamin W Townsend Donatus C Ohanehi David A Dillard | 2011 | International Journal of Adhesion and Adhesives2011，31，7： | 1 |
| 9 | Prospects for Measurement-Based Quantum Computing with Solid State Spins显示文摘 | Benjamin S C Lovett B W Smith J M | | 0，，06： | 1 |
| 10 | Adaptive traffic signal control using approximate dynamic program- ming显示文摘 | Chen C Chi K W Benjamin G H | 2009 | Transportation Research Part C2009，17，5： | 1 |
| 11 | The decrease of UV absorbance as an indicator of TOX formation显示文摘 | Korshin G V Li C W Benjamin M M | 1997 | Wat Res1997，31，4： | 1 |
| 12 | Should patients with polycystie ovary syndrome be treated with mefformin? Benefits of insulin sensitizing drugs in polycystic ovary syndrome beyond ovulation induce显示文摘 | Laurel A Benjamin C Oehninger W S | 2002 | Human Rep roduetion2002，17，12： | 1 |
| 13 | Retail leasing: the determinants of shopping center rents 显示文摘 | BENJAMIN J D BOYLE G W SIRMANS C F | 1990 | AREUEA Journal1990，18，3： | 1 |
| 14 | Price discrimination in shopping center leases显示文摘 | BENJAMIN J D BOYLE G W SIRMANS C F | | Journal of Urban Economics0，32，： | 1 |
| 15 | Price Discrimination in Shopping Center Leases 显示文摘 | BENJAMIN J D BOYLE G W SIRMANS C F | 1992 | Journal of Urban Economics1992，32，3： | 1 |
| 16 | Waterdispersible Magnetic carbon nanotubes as T2-weighted MRI contrast agents显示文摘 | Liu Yue Timothy C Hughes Benjamin W Muir | 2014 | Biomaterials2014，35，1： | 1 |
| 17 | X-Ray Absorp-tion Fine Structure Characterization of the Local Structure ofFe in Fe-ZSM-5 显示文摘 | Sun H C Benjamin R W Jason A R | 2003 | J Phys Chem B2003，107，11： | 1 |
| 18 | Initial experience with combined en- doscopic third ventrieulostomy and choroid plexus cauterization for posthemorrhagie hydrocephalus of prematurity: the impor- tance of prepontine cistern status and the predictive value of FI- ESTA MRI imaging显示文摘 | Benjamin C Jeffrey W | 2011 | Childs Nerv Syst2011，27，7： | 1 |
| 19 | The decrease of UV absorbance as an indicator of TOX formation显示文摘 | Korshin G Li C W Benjamin M 1997 | 1997 | Water Res1997，31，4： | 1 |
| 20 | Pyrolysis of tetralin显示文摘 | BENJAMIN B M HAGAMAN E W RAAEN V F COLLINS C J | 1979 | Fuel1979，58，5： | 1 |
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