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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Transcriptomic and metabolomic analyses of cucumber fruit peels reveal a developmental increase in terpenoid glycosides associated with age-related resistance to Phytophthora capsici显示文摘The oomycete,Phytophthora capsici,infects cucumber(Cucumis sativus L.)fruit.An age-related resistance(ARR)to this pathogen was previously observed in fruit of cultivar‘Vlaspik’and shown to be associated with the peel.Young fruits are highly susceptible,but develop resistance at~10–12 days post pollination(dpp).Peels from resistant(16 dpp)versus susceptible(8 dpp)age fruit are enriched with genes associated with defense,and methanolic extracts from resistant age peels inhibit pathogen growth.Here we compared developing fruits from‘Vlaspik’with those of‘Gy14’,a line that does not exhibit ARR.Transcriptomic analysis of peels of the two lines at 8 and 16 dpp identified 80 genes that were developmentally upregulated in resistant‘Vlaspik’16 dpp versus 8 dpp,but not in susceptible‘Gy14’at 16 dpp.A large number of these genes are annotated to be associated with defense and/or specialized metabolism,including four putative resistance(R)genes,and numerous genes involved in flavonoid and terpenoid synthesis and decoration.Untargeted metabolomic analysis was performed on extracts from 8 and 16 dpp‘Vlaspik’and‘Gy14’fruit peels using Ultra-Performance Liquid Chromatography and Quadrupole Time-of-Flight Mass Spectrometry.Multivariate analysis of the metabolomes identified 113 ions uniquely abundant in resistant‘Vlaspik’16 dpp peel extracts.The most abundant compounds in this group had relative mass defects consistent with terpenoid glycosides.Two of the three most abundant ions were annotated as glycosylated nor-terpenoid esters.Together,these analyses reveal potential mechanisms by which ARR to P.capsici may be conferred. | Ben N Mansfeld Marivi Colle Yunyan Kang A Daniel Jones Rebecca Grumet | 2017 | Horticulture Research2017，4，1： | 3 |
| 3 | Relevance of proteolysis and proteasome activation in fatty liver graft preservation: An Institut Georges Lopez-1 vs University of Wisconsin appraisal显示文摘AIM To compare liver proteolysis and proteasome activation in steatotic liver grafts conserved in University of Wisconsin(UW) and Institut Georges Lopez-1(IGL-1)solutions.METHODS Fatty liver grafts from male obese Zücker rats were conserved in UW and IGL-1 solutions for 24 h at 4 ℃and subjected to 'ex vivo ' normo-thermic perfusion(2 h; 37 ℃). Liver proteolysis in tissue specimens and perfusate was measured by reverse-phase high performance liquid chromatography. Total free amino acid release was correlated with the activation of the ubiquitin proteasome system(UPS: measured as chymotryptic-like activity and 20 S and 19 S proteasome), the prevention of liver injury(transaminases), mitochondrial injury(confocal microscopy) and inflammation markers(TNF 1 alpha, high mobility group box-1(HGMB-1) and PPAR gamma), and liver apoptosis(TUNEL assay, cytochrome c and caspase 3).RESULTS Profiles of free AA(alanine, proline, leucine, isoleucine, methionine, lysine, ornithine, and threonine, among others) were similar for tissue and reperfusion effluent. In all cases, the IGL-1 solution showed a significantly higher prevention of proteolysis than UW(P < 0.05) after cold ischemia reperfusion. Livers conserved in IGL-1 presented more effective prevention of ATP-breakdown and more inhibition of UPS activity(measured as chymotryptic-like activity). In addition, the prevention of liver proteolysis and UPS activation correlated with the prevention of liver injury(AST/ALT) and mitochondrial damage(revealed by confocal microscopy findings) as well as with the prevention of inflammatory markers(TNF1alpha and HMGB) after reperfusion. In addition, the liver grafts preserved in IGL-1 showed a significant decrease in liver apoptosis, as shown by TUNEL assay and the reduction of cytochrome c, caspase 3 and P62 levels. CONCLUSION Our comparison of these two preservation solutions suggests that IGL-1 helps to prevent ATP breakdown more effectively than UW and subsequently achieves a higher UPS inhibition and reduced liver proteolysis. | Mohamed Amine Zaouali Arnau Panisello-Roselló Alexandre Lopez Carlos Castro Benítez Emma Folch-Puy Agustín García-Gil Teresa Carbonell RenéAdam Joan Roselló-Catafau | 2017 | World Journal of Gastroenterology2017，23，23： | 3 |
| 4 | Direct characterization of a nonlinear photonic circuit’s wave function with laser light显示文摘Integrated photonics is a leading platform for quantum technologies including nonclassical state generation1–4,demonstration of quantum computational complexity5 and secure quantum communications6.As photonic circuits grow in complexity,full quantum tomography becomes impractical,and therefore an efficient method for their characterization7,8 is essential.Here we propose and demonstrate a fast,reliable method for reconstructing the two-photon state produced by an arbitrary quadratically nonlinear optical circuit.By establishing a rigorous correspondence between the generated quantum state and classical sum-frequency generation measurements from laser light,we overcome the limitations of previous approaches for lossy multimode devices9,10.We applied this protocol to a multi-channel nonlinear waveguide network and measured a 99.28±0.31%fidelity between classical and quantum characterization.This technique enables fast and precise evaluation of nonlinear quantum photonic networks,a crucial step towards complex,largescale,device production. | Francesco Lenzini Alexander N Poddubny James Titchener Paul Fisher Andreas Boes Sachin Kasture Ben Haylock Matteo Villa Arnan Mitchell Alexander S Solntsev Andrey A Sukhorukov Mirko Lobino | 2018 | Light(Science & Applications)2018，7，1： | 2 |
| 5 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 6 | Completeness of malaria notification in Tunisia assessed by capture recapture method显示文摘 | N Ben Alaya-Bouafif MK Chahed H El Bez H Bellali L Ayari N Achour | 2011 | Asian Pacific Journal of Tropical Disease2011，，3： | 2 |
| 7 | Defining the nature of human pluripotent stem cell progeny显示文摘当人的 pluripotent 干细胞(hPSCs ) 能区分产生各种各样的房间类型的一件礼服,是清楚的时,在 vitro,开发怎么仔细反射那,是未知的哪个发生在 vivo。决定人的胚胎的干细胞(hESCs ) 和导致人的 pluripotent 干细胞(hiPSCs ) 是否做相等的子孙,并且是否也使房间成为那类似于导出织物的房间,我们执行了净化的 PSC 衍生物和他们的导出织物的对应物介绍的全面 transcriptome。表示介绍证明 hESCs 和 hiPSCs 在 hiPSC 子孙用外长的 reprogramming 因素为重新表示的神经、肝、间充质的系,和缺席做将近相同的子孙。不管多么与一个导出织物的对应物相比, hESCs 和 hiPSCs 的子孙维持了通常与早哺乳动物的开发联系的基因的一个子集的表示,不管产生的房间的类型。当 pluripotent 基因(OCT4, SOX2, REX1,和 NANOG ) 看起来在从 hPSCs 的区别之上立即是 silenced 时,对早胚胎(LIN28A, LIN28B, DPPA4,和其它) 通常独特的基因不是充分在 hPSC 衍生物的 silenced。从在早人的胎儿的织物(开发的 3-16 星期) 的表达式模式的这些数据和证据建议 hPSCs 的区分的子孙很早人的开发是反射的(< 6 个星期) 。这些调查结果为 hPSCs 能在早人的开发的 vitro 模型作为有用服务的想法提供支持,而且为疾病建模和 hPSC 衍生物的临床的申请提出重要问题。 | Michaela Patterson David N Chan IrisHa Dana Case Yongyan Cui Ben Van Hande Hanna KA Mikkola William E Lowry | 2012 | Cell Research2012，22，1： | 2 |
| 8 | PPARα and PPARδ activators inhibit cytokine-induced nuclear translocation of NF-κB and expression of VCAM-1 in EAhy926 endothelial cells显示文摘 | Rival Y Benéteau N Taillandier T | 2002 | European Journal Pharmacology2002，435，8： | 2 |
| 9 | Antioxidant defense system in leaves of Indian mustard (Brassica juncea) and rape (Brassvica napus) under cadmium stress显示文摘 | Nouairi I Ben Ammar W Ben Youssef N | 2009 | Acta Physiologiae Plantarum2009，31，2： | 1 |
| 10 | Functional and safety aspects of enterococei isolated from different Spanish foods显示文摘 | Ben Omar N Castro A Lueas R | 2004 | Syst Appl Microbiol2004，27，1： | 1 |
| 11 | Simulation of IR images of natural backgrounds显示文摘 | Ben Y N Rahat B Feigin G | 1983 | Applied Optics1983，22，1： | 1 |
| 12 | Association between oxi dative stress parameters and inflammation markers according to the gravity of the acute coronary syndrome显示文摘 | Nakbi A Koubaa N Ben Hamda K | 2011 | Tunis Med2011，89，7： | 1 |
| 13 | Multiplex nested RT-PCR for the detection of porcine enteric viruses显示文摘 | Ben Salem A N Chupin Sergei A Bjadovskaya Olga P | 2010 | J Virol Meth2010，165，2： | 1 |
| 14 | High-frequency os- cillatory ventilation in pediatric patients with acute respirato- ry failure显示文摘 | Ben Jaballah N Khaldi A Mnif K | 2006 | Pediatr Crit Care Med2006，7，4： | 1 |
| 15 | Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein(MOG) -derived peptide: preliminary analysis of MOG T cell epitopes显示文摘 | Kedero de Rosbo N Mendel I Ben - Nun A | 1995 | Eur J Immunol1995，25，4： | 1 |
| 16 | Urinary IL-18 and NGAL as early predictive biomarkers in contrast-induced nephropathy after coronary angiography显示文摘 | Ling W Zhaohui N Ben H | 2008 | Nephron Clin Praet2008，108，3： | 1 |
| 17 | Sorption and desorption characteristics of a packed bed of clay-CaCl2 desiccant particles 显示文摘 | Tretiak C S Ben A N | 2009 | Solar Energy2009，83，10： | 1 |
| 18 | Transition from the Anodic Arc Phase to the Cathodic Metallic Arc Phase in Vacuum at Low DC Electrical LeveI显示文摘 | Ben Jemma N Morin L | 2002 | IEEE Transactions on Components Packaging Technologies2002，25，4： | 1 |
| 19 | Polyphasic study of the spatial distribution of microorganisms in Mexican Pozol, a fer- mented maize dough, demonstrates the need for cultivation-inde- pendent methods to investigate traditional fermentations显示文摘 | Ampe F Ben Omar N Moizan C | 1999 | Ap- plied and Environmental Microbiology1999，，65： | 1 |
| 20 | Novel roles of pro- lactin and estrogens in breast cancer: resistance to chemotherapy显示文摘 | Lapensee EW Ben - Jonathan N | 2010 | Emdoerine - Related Cancer2010，17，： | 1 |
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