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| 1 | 论思维和STEM教育显示文摘随着全球化的STEM教育领域的迅速发展,各国对跨学科研究以及开发更新、更深入的STEM教育的学术研究的呼声也越来越高.文章聚焦思维这个话题,首先从历史发展的视角,简要概括分析了有关思维的不同观点,包括哲学的、心理的和学科的,揭示了思维概念和研究的历史传承.但在新兴的STEM教育背景下,思维需要重新概念化.文章提出了思维是多元的观点,初步探讨了STEM融合教育的这种方式,能够为学生提供充分的机会来有效地发展多元思维模式,并对未来关于思维的研究提出了可能的新研究领域和方向. | 李业平 SCHOENFELD A H DISESSA A A GRAESSER A C BENSON L C ENGLISH L D DUSCHL R A | 2019 | 数学教育学报2019，0，3： | 10 |
| 2 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 3 | Imaging of the temporomandibular joint: An update显示文摘Imaging of the temporomandibular joint(TMJ) is continuously evolving with advancement of imaging technologies. Many different imaging modalities are currently used to evaluate the TMJ. Magnetic resonance imaging is commonly used for evaluation of the TMJ due to its superior contrast resolution and its ability to acquire dynamic imaging for demonstration of the functionality of the joint. Computed tomography and ultrasound imaging have specific indication in imaging of the TMJ. This article focuses on state of the art imaging of the temporomandibular joint. Relevant normal anatomy and biomechanics of movement of the TMJ are discussed for better understanding of many TMJ pathologies. Imaging of internal derangements is discussed in detail. Different arthropathies and commontumors are also discussed in this article. | Asim K Bag Santhosh Gaddikeri Aparna Singhal Simms Hardin Benson D Tran Josue A Medina Joel K Curé | 2014 | World Journal of Radiology2014，6，8： | 5 |
| 4 | Status review of mercury control options for coal-fired power plants显示文摘 | John H Pavlish Everett A Sondreal Michael D Mann Edwin S Olson Kevin C Galbreath Dennis L Laudal Steven A Benson | 2003 | Fuel Processing Technology2003，，2： | 4 |
| 5 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 6 | Identification of telmisartan as a unique angiotensin Ⅱ receptor antagonist with selective PPARγ-modulating activity 显示文摘 | BENSON S C PERSHADSINGH H A HO C I | 2004 | Hypertension2004，43，5： | 1 |
| 7 | Fragmentation of metal rings by electromagnetic loading 显示文摘 | Grady D E Benson D A | 1983 | Experimental Mechanics1983，23，4： | 1 |
| 8 | Mechanical properties of nanocrystalline materials显示文摘 | MEYERS M A MISHRA A BENSON D J | 2006 | Progress in Materials Science2006，51，： | 1 |
| 9 | The use of prostate specific antigen density to enhance the predictive value of intermediate levels of serum prostate specific antigen显示文摘 | BENSON M C WHANG I S OLSSON C A | 1992 | J Urol1992，147，： | 1 |
| 10 | Identification of telmisartan as a unique angiotensin Ⅱ receptor antagonist with selective ppargamma- modulating activity 显示文摘 | Stephen C Benson Harrihar A Pershadsingh Christopher I Ho | 2004 | Hypertension2004，43，： | 1 |
| 11 | Arsenic accumulation in great barrier reef invertebrates显示文摘 | BENSON A A Summons R E | 1981 | Science1981，211，： | 1 |
| 12 | GenBank显示文摘 | Benson D A Karsch-Mizrachi I Lipman D J | 2000 | Nucleic Acids Research2000，28，1： | 1 |
| 13 | Database resources of the National Center for Biotechnology Information显示文摘 | Wheeler D L Barrett T Benson D A | 2006 | Nucleic Acids Res2006，34，： | 1 |
| 14 | GenBank 显示文摘 | BENSON D A KARSCH-MIZRACHI I LIPMAN D J | 2010 | Nucleic Acids Research2010，38，1： | 1 |
| 15 | Outcome of pregnancy after prenatal diagnosis of umbilical vein varix显示文摘 | Rahemtullah A Lieberman E Benson C | | 0，，： | 1 |
| 16 | Comparing ICP and ECR Etching of HgCdTe, CdZnTe and CdTe 显示文摘 | A J Stohz J B Varesi J D Benson | 2007 | Journal of Electronic Materials2007，36，8： | 1 |
| 17 | Direct trajectory optimization and eostate estimation via an orthogohal collocation method 显示文摘 | Benson D A Huntington G T Thorvaldsen T P Rao A V | 2006 | Journal of Guidance Control and Dynamics2006，29，6： | 1 |
| 18 | Sulfamic acid and its N-substituted derivatives显示文摘 | Benson G A Sillane W J | 1980 | Chem Rev1980，80，2： | 1 |
| 19 | Direct trajectory optimization and costate estimation via an orthogonal collocation method 显示文摘 | Benson D A Hunting Ton G T Thorvaldsen T P | 2006 | Journal of Guidance Control and Dynamics2006，29，6： | 1 |
| 20 | The unique enve lope gene of the subgroup J avian leukosis virus de rives from ev/J provirus, a novel family of avian en dogenous viruses显示文摘 | Benson S J Ruis B Fadly A M | 1998 | J Virol1998，72，10： | 1 |
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