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| 1 | Evidence that chronic hypoxia causes reversible impairment on male fertility显示文摘瞄准:在人的精子发生的参数和他们的复原时间上评估长期的组织缺氧的效果。方法:六男健康的山缓慢艰辛地旅行 ers 的 Seminological 参数在海水平在 normoxia 被评估。在到高度的 26 天暴露以后(从 2 000 m 到 5 600 m,古代蒙古帝国旧都遗迹远征) 一样的参数再在回到海水平以后被评估。这些参数再次在 6 个月以后在 1 个月以后然后再被评估。结果:精子计数被发现在回到海水平以后立即更低(P = 0.0004 ) 并且再在一个月以后(P = 0.0008 ) 。正常层次在 6 个月以后被到达。精子的活动性(%) 不在回到海水平以后立即显示出减小(P = 0.0583 ) ,而在 1 个月以后这减小是重要的(P = 0.0066 ) 。在 6 个月以后,到 pre-hypoxic 暴露值有恢复。在回到海以后立即增加的反常或不成熟的精子(%) 铺平(P = 0.0067 ) 然后再在 1 个月以后(P = 0.0004 ) 。在 6 个月以后,到起始的值有完全的恢复。在精液的能动精子的全部的数字被发现在回到海水平以后立即更低(P = 0.0024 ) 然后再在 1 个月以后(P = 0.0021 ) 。在 6 个月以后,到 pre-hypoxic 暴露值有恢复。结论:在 6 个月在精子发生和男富饶的生理的机制显示氧供应的影响以后,长期的组织缺氧在以前的 normoxic 条件的恢复导致精子减少的一个状态和如此的 seminological 参数的正规化。 | Vittore Verratti Francesco Berardinelli Camillo Di Giulio Gerardo Bosco Marisa Cacchio Mario Pellicciotta Michele Nicolai Stefano Martinotti Raffaele Tenaglia | 2008 | Asian Journal of Andrology2008，10，4： | 21 |
| 2 | Relationship between Fusobacterium nucleatum,inflammatory mediators and microRNAs in colorectal carcinogenesis显示文摘AIM To examine the effect of Fusobacterium nucleatum(F. nucleatum) on the microenvironment of colonic neoplasms and the expression of inflammatory mediators and microRNAs(miRNAs).METHODS Levels of F. nucleatum DNA, cytokine gene mRNA(TLR2, TLR4, NFKB1, TNF, IL1 B, IL6 and IL8), and potentially interacting miRNAs(miR-21-3p, miR-22-3p, mi R-28-5p, miR-34a-5p, miR-135b-5p) were measured by quantitative polymerase chain reaction(qPCR) TaqMan? assays in DNA and/or RNA extracted from the disease and adjacent normal fresh tissues of 27 colorectal adenoma(CRA) and 43 colorectal cancer(CRC) patients. KRAS mutations were detected by direct sequencing and microsatellite instability(MSI) status by multiplex PCR. Cytoscape v3.1.1 was used to construct the postulated miRNA:mRNA interaction network.RESULTS Overabundance of F. nucleatum in neoplastic tissue compared to matched normal tissue was detected in CRA(51.8%) and more markedly in CRC(72.1%). We observed significantly greater expression of TLR4, IL1 B, IL8, and miR-135 b in CRA lesions and TLR2, IL1 B, IL6, IL8, mi R-34 a and miR-135 b in CRC tumours compared to their respective normal tissues. Only two transcripts for miR-22 and miR-28 were exclusively downregulated in CRC tumour samples. The mRNA expression of IL1 B, IL6, IL8 and miR-22 was positively correlated with F. nucleatum quantification in CRC tumours. The mRNA expression of miR-135 b and TNF was inversely correlated. The miRNA:mRNA interaction network suggested that the upregulation of miR-34 a in CRC proceeds via a TLR2/TLR4-dependent response to F. nucleatum. Finally, KRAS mutations were more frequently observed in CRC samples infected with F. nucleatum and were associated with greater expression of miR-21 in CRA, while IL8 was upregulated in MSI-high CRC.CONCLUSION Our findings indicate that F. nucleatum is a risk factor for CRC by increasing the expression of inflammatory mediators through a possible mi RNA-mediated activation of TLR2/TLR4. | Marcela Alcantara Proenca Joice Matos Biselli Maysa Succi Fábio Eduardo Severino Gustavo Noriz Berardinelli Alaor Caetano Rui Manuel Reis David J Hughes Ana Elizabete Silva | 2018 | World Journal of Gastroenterology2018，24，47： | 15 |
| 3 | The impact of minimally invasive surgeries for the treatment of symptomatic benign prostatic hyperplasia on male sexual function: a systematic review显示文摘使随机化的控制试用和队研究的系统的评论被进行在男性功能上为征兆的良性的 prostatic 增生(BPH ) 的处理为最低限度地侵略的过程的效果评估数据。寻找的研究是与征兆的 BPH 注册了人的试用与激光手术,经尿道的微波治疗( TUMT ),前列腺(金枪鱼)的经尿道的针脱离,前列腺( TEAP )的经尿道的乙醇脱离和高紧张的频率超声( HIFU )被对待,与前列腺( TURP )或假冒的操作的传统的经尿道的切除术比较。72 研究的一个总数被识别,哪个 33 满足了包括标准。33 研究, 21 涉及了激光手术,六与 TUMT,四与金枪鱼并且二与包含信息考虑的 TEAP 男性功能。没有学习关于为男性功能上的 BPH 的 HIFU 的效果是可得到的。我们的分析证明为 BPH 的最低限度地侵略的手术在男可勃起的功能上 TURP 有可比较的效果到那些。一起,分别地,不到 15.4% 病人或 15.2% 将在激光过程, TUMT 和金枪鱼以后可勃起的功能有减少或增加。是与 TURP 观察了,射精的机能障碍(EjD ) 的高发生在有钬, potassium-titanyl-phosphate 和铥激光治疗的 BPH 的治疗以后是普通的(>33.6%) 。TUMT,金枪鱼和 neodymium:yttrium 铝石榴石为 BPH 的视觉激光脱离或空隙的激光凝结有更少的发生 EjD,而是这些过程为 BPH 治疗被认为更少有效什么时候与 TURP 相比。 | Ryan W. Frieben Hao-Cheng Lin Peter E Hinh Francesco Berardinelli Steven E. Canfield Run Wang | 2010 | Asian Journal of Andrology2010，12，4： | 13 |
| 4 | Damage to pears caused by simulated transport显示文摘 | BERARDINELLI A DONATI V GIUNCHI A | 2005 | Journal of Food Engineering2005，66，2： | 1 |
| 5 | Damage to pears caused by simulated transport显示文摘 | BERARDINELLI A DONATI V GIUNCHI A | 2005 | Journal of Food Engineering2005，66，： | 1 |
| 6 | Needs of nursing guidance for self-care of clients on hemodialysis therapy 显示文摘 | Dos S I Rocha R P Berardinelli L M | 2011 | Rev Bras Enferm2011，64，2： | 1 |
| 7 | New therapy for women with irritable bowel syndrome显示文摘 | Kupecz D Berardinelli C | 2003 | Nurse Practitionerl2003，28，4： | 1 |
| 8 | Technologies for the removal of phenol from fluid streams: a short review of recent developments 显示文摘 | BUSCA G BERARDINELLI S RESINI C | 2008 | Journal of Hazardous Materials2008，160，23： | 1 |
| 9 | Lessons from 494 permanent accesses in 348 haemodialysis patients older than 65 years of age:29 years of experience显示文摘 | Berardinelli L Vegeto A | 1998 | Nephrol Dial Transplant1998，13，7： | 1 |
| 10 | Effect of sinusoidal vibration on quality indices of shell eggs biosystems engineering显示文摘 | Berardinelli A Donati V Giunchi A | 2003 | Animal Production Technology2003，86，3： | 1 |
| 11 | Damage to pears caused by simulated transport显示文摘 | Berardinelli A Donati V | 2005 | Journal of Food Engineering2005，66，2： | 1 |
| 12 | Best results in living donor transplantation using an aggressive policy in microsurgical bench reconstruction of nonoptimal arterial supply显示文摘 | Berardinelli L | 2006 | Transplant Proc2006，38，4： | 1 |
| 13 | Damage to pears caused by simulated transport显示文摘 | Berardinelli A Donati V Giunchi A | 2005 | Journal of Food Engineering2005，66，： | 1 |
| 14 | Mechanical Behaviour of Apples,and Damage during Sorting and Packaging显示文摘 | RANGI L BERARDINELLI A | 2001 | J agric Engng Res2001，78，3： | 1 |
| 15 | Techno- logies for the removal of phenol from fluid streams: A short review of recent developments 显示文摘 | BUSCA G BERARDINELLI S RESINI C | 2008 | Journal of Haz- ardous Materials2008，160，23： | 1 |
| 16 | Effect of sinusoidal vibration on quality indices of shell eggs, biosystems engineering 显示文摘 | Berardinelli A V Donati A Giunchi | 2003 | Animal Production Technology2003，86，3： | 1 |
| 17 | Technologies for the removal of phenol from fluid streams: A short review of recent developments 显示文摘 | Busca G Berardinelli S | 2008 | Journal of Hazardous Materials2008，160，： | 1 |
| 18 | The role of hypoxia in erectile dysfunction mechanisms 显示文摘 | Verratti V Giulio C Di Berardinelli F | 2007 | International Journal of Impotence Research2007，，19： | 1 |
| 19 | Expression of telomerase reverse transcriptase subunit (TERT)and telomere sizing in pig ovarian follicles显示文摘 | Russo V Berardinelli P Martelli A | 2006 | J Histochem Cytochem2006，54，4： | 1 |
| 20 | Technologies for the removal of phenol from fluid streams: a short review of recent developments显示文摘 | Busca G Berardinelli S Resini C | 2008 | Journal of Hazardous Materials2008，160，23： | 1 |
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