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| 1 | Faecalibacterium prausnitzii and human intestinal health显示文摘 | S Miquel R Martín O Rossi LG Bermúdez-Humarán JM Chatel H Sokol M Thomas JM Wells P Langella | 2013 | Current Opinion in Microbiology2013，，： | 3 |
| 2 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 3 | Influence of ZnO nanoparticle filler on the properties and wear resistance of polycarbonate 显示文摘 | Carri'on F J Sanes J Berm'udez M D | 2007 | Wear2007，262，1112： | 1 |
| 4 | Role of pulse pressure, systolic blood pressure, and diastolic blood pressure in the prediction of cardiovascular risk Cohort study 显示文摘 | Baena-Diez JM Berm 3dez-Chillida N Garcia-Lareo M | 2008 | Med Clin2008，130，10： | 1 |
| 5 | Effect of in vitro hemolysis on chemical values for serum显示文摘 | FRANK J J BERMES E W BICKEL M J | 1978 | Clin Chem1978，24，11： | 1 |
| 6 | Distinctive postprandial modulation of β cell function and insulin sensitivity by dietary fats:monounsaturated compared with saturated fatty acids显示文摘 | Sergio López Beatriz Bermúdez Yolanda M Pacheco | 2008 | Am J Clin Nutr2008，88，： | 1 |
| 7 | Equilibrium prediction of CO2 reforming of coke oven gas: suitability for methanolproduction显示文摘 | Bermúdez J M Arenillas A Menéndez J A | 2012 | Chemical Engineering Science2012，82，1： | 1 |
| 8 | Morphological description and comparison of the dental remains from Atapuerca-Sima de los Huesos site(Spain)显示文摘 | Martinón-Torres M Bermúdez de Castro JM Gómez-Robles A | 2012 | Journal of Human Evolution2012，62，1： | 1 |
| 9 | New European driving cycle assessment by means of particle size distributions in a light-duty diesel engine fuelled with different fuel formulations显示文摘 | Bermúdez V Luján J M Ruiz S | 2015 | Fuel2015，140，： | 1 |
| 10 | Middle Pleistocene Hominin Teeth from Longtan Cave,Hexian,China显示文摘 | Xing S Martinón-Torres M Bermúdez de Castro JM | 2014 | PLo S ONE2014，9，11： | 1 |
| 11 | Hominin teeth from the early Late Pleistocene site of Xujiayao,Northern China显示文摘 | Xing S Martinón-Torres M Bermúdez de Castro JM | 2015 | American Journal of Physical Anthropology2015，156，2： | 1 |
| 12 | Comparative analysis of a DI diesel engine fuelled with biodiesel blends during theEuropean MVEG-A cycle:Performance and emissions(II)显示文摘 | Luján J M Bermúdez V Tormos B | 2009 | Biomass and Bioenergy2009，33，： | 1 |
| 13 | Nonlinear Lamb waves for the detection of material nonlinearity 显示文摘 | Bermes C Kim J Y Qu J M Jaeobs L J | 2008 | Mechanical Systems and Signal Processing2008，22，： | 1 |
| 14 | rl]e impact of blood glucose serf-monitoring on metabolic control and quality of life in type 2 dialetic pa- tients: an urgent need for better educational strategies显示文摘 | Franeiesi M Pellegrini F Berm'dis G | 2001 | Diabetes Care2001，24，： | 1 |
| 15 | Myotonic dystrophy expanded CUG repeats disturb the expression and phosphorylation of tau in PC12 cells显示文摘 | Hernández-Hernández O Bermúdez-de-León M Gómez P | 2006 | J Neurosci Res2006，84，4： | 1 |
| 16 | Friction and wear of aluminium steel contacts lubricated with ordered fluids-neutral and ionic liquid crystals as oil additives 显示文摘 | Iglesias P Bermúdez M D Carrión F J | 2004 | Wear2004，256，： | 1 |
| 17 | Intersitial Chemotherapy with Drug Polymer Implants for the Treatment of Recurrent Gliomas显示文摘 | Berm H Mahalty M S Nichola A V | 1991 | J Neurosurg1991，，74： | 1 |
| 18 | On the single domain nature of stoichiometric LiNbO3 grown from melts containing K2O 显示文摘 | Dutta P S Serrano M D | 1997 | Appl Phys Lett1997，10，6： | 1 |
| 19 | Dry refor- ming of coke oven gases over activated carbon to pro- duce syngas for methanol synthesis显示文摘 | Berm Dez J M Fidalgo B Arenillas A | 2010 | Fuel2010，89，10： | 1 |
| 20 | Influence of processing method on comparative digestion of white corn versus conventional steam-flaked yellow dent corn in finishing diets for feedlot cattle显示文摘 | Plascencia A Bermúdez R M Cervantes M | 2011 | Journal of Animal Science2011，89，1： | 1 |
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