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| 1 | Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease显示文摘AIM: To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn’s disease (CD). METHODS: A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn’s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants (Arg702Trp, Gly908Arg and 1007finsC changes) with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specifi c regions of these genes.RESULTS: At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profi le was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls (9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls). No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION: The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD. | Judit Bene Lili Magyari Gábor Talián Katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 3 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010，18，12： | 4 |
| 4 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 5 | Oxidized p-hospholipids alter vascular connexin expression,phosphorylation,and heterocellular communication显示文摘 | ISAKSON BE KRONKE G KADL A | 2006 | Arterioscler Thromb Vasc Biol2006，26，10： | 1 |
| 6 | Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia显示文摘 | Perry EK Tomlinson BE Blessed G Bergmann K Gibson PH Perry RH | | 0，，6150： | 1 |
| 7 | Ultralight- weight and flexible silylated nanocellulose sponges for the selective removal of oil from water 显示文摘 | ZHANG Z S BE G RENTSCH D | 2014 | Chem Ma- ter2014，26，8： | 1 |
| 8 | Pyrrolidine dithiocarbamate exerts anti-proliferative and pro-apoptotic effects in renal cell carcinoma cell lines显示文摘 | Morais C Pat B Go be G | 2006 | Nephrol Dial Transplant2006，21，： | 1 |
| 9 | Defining functional distance using manifold embeddings of gene ontology annotations 显示文摘 | Lerman G Shakhnovich BE | 2007 | Proc Natl Acad Sci USA2007，104，11： | 1 |
| 10 | The association between quan titative measures of dementia and of senile change in the cerebral gray matter of elderly subjects显示文摘 | Tomlinson BE Roth M | 1968 | Br J Psychiatry1968，114，： | 1 |
| 11 | The introduction of computer- based case simulations in to the United States medical licensing examination 显示文摘 | Clyman SG Clauser BE | 2002 | Acad Med2002，77，2： | 1 |
| 12 | Choledocholithiasis--princi- pies of diagnosis and management 显示文摘 | Lahmann BE Adrales G Schwartz RW | 2004 | Curr Surg2004，61，3： | 1 |
| 13 | Engineered multifunctional RGD-gold nanoparticles for the detection of tumour-specific alpha ( v ) beta ( 3 ) expression: chemical characterisation and ecotoxicological risk assessment显示文摘 | Morales-Avila E Ferro-Flores G Ocampo-Garc ~ a BE | 2012 | J Biomed Nanotechnol2012，8，6： | 1 |
| 14 | The attachment scriptrepresentation procedure in an Italian sample: associations with aduh attachment interview scales and with maternal sensitivity显示文摘 | Coppola G Vaughn BE Cassibba R | 2006 | Attach Hum Dev2006，8，3： | 1 |
| 15 | Effect of bile on smooth muscles cell proliferation in TIPS 显示文摘 | TENG G J BE'R'MANN AB HOOPES P J | 1998 | Radiology1998，208，3： | 1 |
| 16 | Physicochem~cal, structural, and digesti~ihty properties of enzymatic modified plantain and mango starches 显示文摘 | Casarrubias- Castillo M G Hamaker B R Rodriguez-Ambriz S L Be~o-P~rez L A_ | 2012 | Starch/Starke2012，64，4： | 1 |
| 17 | Acute failure of automatic respirations secondary to a unilateral brainstem infarct显示文摘 | Margolis G | 1977 | Ann Neurol1977，1，： | 1 |
| 18 | International conference for the develop ment of a consensus on the management and prevention of severe candidal infections显示文摘 | Edwards J E Jr Bodey G P Bowden R A Buchner T de Pauw BE Filler SG | 1997 | Clin Infect Dis1997，25，： | 1 |
| 19 | Annexins in human breast cancer : possible predictors of pathological response to neoadjuvant chemotherapy 显示文摘 | Chuthapisith S Bean BE Cowley G | 2009 | Eur J Cancer2009，45，7： | 1 |
| 20 | Microscopic polyangiitis with unusual lung involvement显示文摘 | Gulbay BE Celik G Kumbasar O | 2005 | Respirology2005，10，5： | 1 |
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