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| 1 | Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy显示文摘AIM: To investigate plasma ghrelin, gastrin and growth hormone secretagogue receptor (GHS-R) expression in advanced gastric cancer (GC) before and after resection. METHODS: Seventy subjects in whom endoscopy of the upper gastrointestinal tract was performed in the Department of General Surgery at Cracow University during the past decade: (1) 25 patients with GC associated with Helicobacter pylori (H. pylori) infection; (2) 10 patients with GC 4-5 years after (total or subtotal) gastrectomy; (3) 25 healthy H. pylori-negative controls, matched by age and BMI to the above two groups; and (4) 10 GC patients 4-5 years after total gastrectomy. Ghrelin and gastrin plasma concentrations were measured by specific radioimmunoassay under fasting conditions and postprandially at 60 and 90 min after ingestion of a mixed meal. GHS-R expression was examined in biopsy samples from intact healthy mucosa and GC tissue using semi-quantitative reverse transcription-polymerase chain reaction. RESULTS: In healthy controls, fasting plasma ghrelin levels were significantly elevated and declined markedly at 60 and 90 min after a mixed meal. The concomitant enhanced ghrelin, GHS-R and gastrin expression in GC tissue over that recorded in intact mucosa, and the marked rise in plasma gastrin in these subjects under fasting conditions indicate the role of these hormonal factors in GC formation. Fasting plasma levels and postprandial response of ghrelin and gastrin appear to be inversely correlated in healthy subjects. Feeding in the controls resulted in a significant fall in plasma ghrelin with a subsequent rise in plasma gastrin, but in H. pylori-positive GC patients submitted to total or distal gastrectomy, feeding failed to affect significantly the fall in plasma ghrelin that was recorded in these patients before surgery. Fasting ghrelin concentrations were significantly lower in patients 4-5 years after total gastrectomy compared to those in healthy controls and to these in GC patients before surgery. CONCLUSION: Elevated plasma gastrin and suppression of fasting ghrelin in patients with GC suggest the existence of a close relationship between these two hormones in gastric carcinogenesis. | Anna Zub-Pokrowiecka Kazimierz Rembiasz Peter C Konturek Andrzej Budzyński Stanisaw J Konturek Marek Winiarski Wadysaw Bielański | 2011 | World Journal of Gastroenterology2011，17，4： | 7 |
| 2 | Different sensitivity of human endothelial cells, smooth muscle cells and fibroblasts to topography in the nano-micro range 显示文摘 | Biela SA Su Yi Spatz JP | 2009 | Acta Biomater2009，5，： | 1 |
| 3 | 显示文摘 | Kowalski A Libiszowski J Biela T | 2005 | Macromolecules2005，38，： | 1 |
| 4 | Mutations in INPP5E,enco- ding inositol polyphosphate-5-phosphatase E,link phosphatidyl inosi- tol signaling to the ciliopathies 显示文摘 | Bielas SL Silhavy JL Brancati F | 2009 | Nat Genet2009，41，9： | 1 |
| 5 | SiC versus Si-Evaluation of potentials for performance improvement of inverter and dc-dc converter systems by SiC power semiconductors显示文摘 | Biela J Mario S Waffier S | 2011 | IEEE Transactions on Industrial Electronics2011，58，7： | 1 |
| 6 | Implementation of a transformerless common-mode active fdter for Offline converter systems显示文摘 | M L Heldwein H Ertl J Biela J W Kolar | 2010 | IEEE Trans on Industrial Electronics2010，57，5： | 1 |
| 7 | Role of endogenous nitric oxide in the control of exocrine and endocrine pancreatic secretion显示文摘 | Bilski J Konturek S J Bielański W J | 1995 | Physiol Pharmacol1995，46，4： | 1 |
| 8 | Core losses under the DC bias condition based on steinmetz parameters 显示文摘 | Jonas Muhlethaler Jurgen Biela Johann Walter Kolar | 2012 | IEEE Transactions on PowerElectronics2012，27，2： | 1 |
| 9 | Active gate control for current balancing of parallel-connected IGBT modules in solid-state modulators 显示文摘 | BORTIS D BIELA J KOLAR J W | 2008 | IEEE Transactions on Plasma Science2008，36，5： | 1 |
| 10 | Using Transformer Parasitics for Resonant Converters-A Review of the Calculation of the Stray Capacitance of Transformers 显示文摘 | Biela J Kolar J W | 2008 | IEEE Transactions on Industry Applications2008，44，1： | 1 |
| 11 | Stochastic and dynamic modeling of fiber gyros 显示文摘 | S M Bielas | 1994 | SPIE1994，2292，： | 1 |
| 12 | Plasma membrane aquapor-ins in the motor cells of Samanea saman:diurnaland circadian regulation显示文摘 | Meshelion M Becker D Biela A | 2002 | Plant Cell2002，，14： | 1 |
| 13 | Cortical neuronal migration mutants suggest separate but intersecting pathways 显示文摘 | Bielas S Higginbotham H Koizumi H | 2004 | Annu Rev Cell Dev Biol2004，20，： | 1 |
| 14 | The tobacco plasma membrane aquaporin NtAQP1 显示文摘 | FRANKA SIEFRITZ ALEXANDER BIELA MARTIN ECKERT | 2001 | Journal of Experimental Botany2001，52，： | 1 |
| 15 | Plasma membrane aquaporins in the motor cells of Samanea saman : diurnal and circadian regulation显示文摘 | Moshelion M Becker D Biela A | 2002 | Plant Cell2002，14，： | 1 |
| 16 | Impact of power density maximization on efficiency of DC-DC converter systems 显示文摘 | Biela J Badstuebner U Kolar J | 2009 | IEEE Transactions on Power Electronics2009，24，： | 1 |
| 17 | Oogenesis in pig ovaries during the prenatal period:ultraslructure and morphometry显示文摘 | Biela(n)ska-Osuchowska Z | 2006 | Reprod biol2006，6，： | 1 |
| 18 | EMI noise prediction for electronic ballasts 显示文摘 | GIEZENDANNER F BIELA J KOLAR J W | 2010 | IEEE Transactions on Power Electronics2010，25，8： | 1 |
| 19 | SiC versus Sievaluation of potentials for performance improvement of inverter and DC-DC converter systems by SiC power semiconductors显示文摘 | Biela J Schweizer M Waffler S | 2011 | IEEE Transactions on Industrial Electronics2011，58，7： | 1 |
| 20 | The Nicotiana tabacum plasme membrane aquaporin NIAQPI is mercury-insensitive and permeable for glycerol显示文摘 | Biela A Grote K Otto B el al | 1999 | The Plant Journal1999，18，5： | 1 |
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