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| 1 | Alcohol-induced protein hyperacetylation: Mechanisms and consequences显示文摘Although the clinical manifestations of alcoholic liver disease are well-described, little is known about the molecular basis of liver injury. Recent studies have indicated that ethanol exposure induces global protein hyperacetylation. This reversible, posttranslational modification on the ε-amino groups of lysine residues has been shown to modulate multiple, diverse cellular processes ranging from transcriptional activation to microtubule stability. Thus, alcoholinduced protein hyperacetylation likely leads to major physiological consequences that contribute to alcohol-induced hepatotoxicity. Lysine acetylation is controlled by the activities of two opposing enzymes, histone acetyltransferases and histone deacetylases. Currently, efforts are aimed at determining which enzymes are responsible for the increased acetylation of specifi c substrates. However, the greater challenge will be to determine the physiological ramifications of protein hyperacetylation and how they might contribute to the progression of liver disease. In this review, we will fi rst list and discuss the proteins known to be hyperacetylated in the presence of ethanol. We will then describe what is known about the mechanisms leading to increased protein acetylation and how hyperacetylation may perturb hepatic function. | Blythe D Shepard Pamela L Tuma | 2009 | World Journal of Gastroenterology2009，15，10： | 3 |
| 2 | Alcohol-induced alterations of the hepatocyte cytoskeleton显示文摘The hepatocyte cytoskeleton consists of three fi lamentous networks: microtubules, actin microfi laments and keratin intermediate filaments. Because of the abundance of the proteins that comprise each system and the central role each network plays in a variety of cellular processes, the three fi lament systems have been the focus of a host of studies aimed at understanding the progression of alcohol-induced liver injury. In this review, we will briefly discuss the hepatic organization of each cytoskeletal network and highlight some components of each system. We will also describe what is known about ethanol-induced changes in the dynamics and distributions of each cytoskeletal system and discuss what is known about changes in protein expression levels and post-translational modifi cations. Finally, we will describe the possible consequences of these cytoskeletal alterations on hepatocyte function and how they might contribute to the progression of liver disease. | Blythe D Shepard Pamela L Tuma | 2010 | World Journal of Gastroenterology2010，16，11： | 2 |
| 3 | Electrified viscous thin film flow over topography 显示文摘 | TSELUIKO D BLYTH M G PAPAGEORGIOU D T | 2008 | Journal of Fluid Mechanics2008，597，6： | 1 |
| 4 | Distribution of myeloma plasma cells in peripheral blood and bone marrow correlates with CD56 expression显示文摘 | Rawstron A Barrans S Blythe D | 1999 | Br J Haematol1999，104，： | 1 |
| 5 | Identifying and treating eating disorders 显示文摘 | KAPLAN D W BLYTHE M DIAZ A | 2003 | Pediatr2003，111，1： | 1 |
| 6 | Effect of inertia on electrified film over a wavy wall 显示文摘 | TSELUIKO D BLYTH M G | 2009 | Journal of Engineering Mathe- matics2009，65，3： | 1 |
| 7 | E- lectrified film flow over topography at zero Reynolds num- ber: at analytical and computational study 显示文摘 | TSELUIKO D BLYTH M G PAPAGEORGIOU D T | 2011 | Journal of Engineering Mathematics2011，69，2： | 1 |
| 8 | Advanced graphics behind medical virtual realiy:evolution of algorithms,hardware,and software interfaces显示文摘 | Soferman Z Blythe D John N W | | 0，，03： | 1 |
| 9 | The Epidemiology of low back pain显示文摘 | Hoy D Brooks P Blyth F | 2010 | Best Practice and Research Clinical Rheumatology2010，24，6： | 1 |
| 10 | The Epidemiology of low back pain显示文摘 | Hoy D Brooks P Blyth F | 2010 | Best Pratt Res Clin Rheumatol2010，24，6： | 1 |
| 11 | Distribution of myeloma plasma cells in peripheral blood and bone marrow correlates with CD56 expression显示文摘 | Rawstron A Barrans S Blythe D | 1999 | Br J Haematol1999，104，1： | 1 |
| 12 | The effect of linear mixing in the EEG on Hurst exponent estimation显示文摘 | BLYTHE D A J HAUFE S M譈LLER K R | 2014 | Elsevier2014，99，1： | 1 |
| 13 | Effect of the presence of polymer in miniemulsion droplets on the kinetics of polymerization 显示文摘 | Miller C M Blythe P J Sudol E D | 1994 | J Polym Sci PartA: Polym Chem1994，32，： | 1 |
| 14 | The Direet3D 10 system显示文摘 | Blythe D | 2006 | ACM Transactions on Graphics2006，25，3： | 1 |
| 15 | Rise of the graphics processor显示文摘 | Blythe D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
| 16 | Behaviour of the systemic nematicide oxamyl in plants in relation to control of invasion and development of Meloidogyne incognita 显示文摘 | Wright D J Blyth A R K Pearson P E | 1980 | Annals of Applied Biology1980，96，： | 1 |
| 17 | Polymerization of miniemulsions containing predissolved polystyrene and using hexadecane as eostabilizer显示文摘 | Blythe P J Morrison B R Sudol E D | 2000 | Langmuir2000，16，： | 1 |
| 18 | The challenges of being an insider in storytelling research显示文摘 | Blythe S Wilkes L Jackson D | 2013 | Nurse Res2013，21，1： | 1 |
| 19 | Investment risks under uncertain climate change policy显示文摘 | Blyth W Bradley R Bunnc D | 2007 | Energy Policy2007，35，11： | 1 |
| 20 | Distribution of myeloma plasma cells in peripheral blood and bone marrow correlates with CD56 expression显示文摘 | Rawstron A Barrans S Blythe D | 1999 | Br J Haematol1999，104，13： | 1 |
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