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245篇 您的检索式：作者名="Bonora G"

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	题名	作者	年代	出处	被引量
1	Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells显示文摘AIM: To investigate and compare the hepatogenic transdifferentiation of adipose tissue-derived stem cells (ADSC) and bone marrow-derived mesenchymal stem cells (BMSC) in vitro. Transdifferentiation of BMSC into hepatic cells in vivo has been described. Adipose tissue represents an accessible source of ADSC, with similar characteristics to BMSC.METHODS: BMSCs were obtained from patients under-going total hip arthroplasty and ADSC from human adi-pose tissue obtained from lipectomy. Cells were grown in medium containing 15% human serum. Cultures were serum deprived for 2 d before cultivating under similar pro-hepatogenic conditions to those of liver develop-ment using a 2-step protocol with sequential addition of growth factors, cytokines and hormones. Hepatic differ-entiation was RT-PCR-assessed and liver-marker genes were immunohistochemically analysed. RESULTS: BMSC and ADSC exhibited a fibroblastic mor-phology that changed to a polygonal shape when cells differentiated. Expression of stem cell marker Thy1 de-creased in differentiated ADSC and BMSC. However, the expression of the hepatic markers, albumin and CYPs increased to a similar extent in differentiated BMSC and ADSC. Hepatic gene activation could be attributed to in-creased liver-enriched transcription factors (C/EBPβ and HNF4α), as demonstrated by adenoviral expression vec-tors.CONCLUSION: Mesenchymal stem cells can be induced to hepatogenic transdifferentiation in vitro. ADSCs have a similar hepatogenic differentiation potential to BMSC, but a longer culture period and higher proliferation ca-pacity. Therefore, adipose tissue may be an ideal source of large amounts of autologous stem cells, and may become an alternative for hepatocyte regeneration, liver cell transplantation or preclinical drug testing.	Raquel Taléns-Visconti Ana Bonora Ramiro Jover Vicente Mirabet Francisco Carbonell José Vicente Castell María José Gómez-Lechón	2006	World Journal of Gastroenterology2006，12，36：	35
2	The Chronic Kidney Disease Epidemiology Collaboration ( CKD- EPI ) e- quation provides a better definition of cardiovascular burden associated with CKD than the Modification of Diet in Renal Disease( MDRD)Study formula in subjects with type 2 dia- betes显示文摘	PUGLIESE G SOLINI A BONORA E	2011	Atherosclerosis2011，218，1：	1
3	p53 at the endo- plasmie reticulum regulates apoptosis in a Ca^2+ -dependent manner显示文摘	Giorgi C Bonora M Sorrentino G	2015	Proc Natl Acad Sci U S A2015，112，6：	1
4	Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease显示文摘	Targher G Day CP Bonora E	2010	N Engl J Med2010，363，：	1
5	Fasting plasma glucose variability predicts 10-year survival of type 2 diabetic patients:the Verona Diabetes Study显示文摘	Muggeo M Zoppini G Bonora E	2000	Diabetes Care2000，23，1：	1
6	Homeostasis model assess- ment closely mirrors the glucose clamp technique in the assessment of in- sulin sensitivity : studies in subjects with various degrees of glucose toler- ance and insulin sensitivity 显示文摘	Bonora E Targher G Alberiche M	2000	Diabetes Care2000，23，：	1
7	Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity显示文摘	Bonora E Targher G Alberiche M	2000	Diabetes Care2000，23，1：	1
8	Fasting plasma glucose variability predicts:the Verona Diabetes Study显示文摘	Muggeo M Zoppini G Bonora E	2000	Diabeters Care2000，23，1：	1
9	The chronic kidney disease ep- idemiology collaboration ( CKD - EPI) equation provides a better defi- nition of cardiovascular burden associated with CKD than the modifi- cation of diet in renal disease (MDRD) study formula in subjects with type 2 diabetes 显示文摘	Pugliese G Solini A Bonora E	2011	Atherosclerosis2011，218，：	1
10	Fasting plasma glucose variability predicts 10-year survival of type 2 diabetic patients: the Verona Diabetes Study 显示文摘	Muggeo M Zoppini G Bonora E	2000	Diabetes Care2000，23，1：	1
11	Relationship between fast-ing insulin and cardiovascular risk factors is already present in young men:the verona young men atherosclerosis risk factors study 显示文摘	Bonora E Targher G Zenere MB	1997	Eur J Clin Invest1997，27，3：	1
12	Innovative non-destructive device for fruit quality assessment显示文摘	Costa G Bonora E Fiori G	2011	Acta Horticulturae italy2011，，913：	1
13	Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity 显示文摘	BONORA E TARGHER G ALBERICHE M	2000	Diabetes Care2000，23，：	1
14	Risk of cardiovascular diseases in patients with nonalcoholic fatty liver discases显示文摘	Targher G Day CP Bonora E	2010	N Eng J Med2010，363，14：	1
15	Fasting plasma glucose variability predicts 10-year survival of type 2 diabetes patients: the Verona Diabetes Study显示文摘	Muggeo M Zoppini G Bonora E	2000	Diabetes Care2000，23，1：	1
16	Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease显示文摘	Targher G Day CP Bonora E	2010	N Engl J Med2010，363，14：	1
17	Homeostasismodel assessment close y mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity 显示文摘	Bonora E Targher G Alberiche M	2000	Diabetes Care2000，23，1：	1
18	Prevalence and correlates of post-prandial hyperglycaemia in a large sample of patients with type 2 diabetes mellitus 显示文摘	BONORA E CORRAO G BAGNARDI V	2006	Diabetologia2006，49，5：	1
19	Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity:studies in subjects with various degrees of glucose tolerance and insulin sensitivity显示文摘	Targher G Alberiche M	2000	Diabetes Care2000，25，3：	1
20	Homeostasis model mirrors the glucose clamp technique and insulin sensitivity显示文摘	Bonora E Targher G Alberiche M	2002	Diabetes Care2002，25，3：	1

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