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| 1 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 2 | Are faecal markers good indicators of mucosal healing in inflammatory bowel disease?显示文摘AIM: To review the published literature concerning the accuracy of faecal inflammatory markers for identifying mucosal healing. METHODS: Bibliographical searches were performed in MEDLINE electronic database up to February 2015,using the following terms: 'inflammatory bowel disease','Crohn′s disease','ulcerative colitis','faecal markers','calprotectin','lactoferrin','S100A12','endoscop*','mucosal healing','remission'. In addition,relevant references from these studies were also included. Data were extracted from the published papers including odds ratios with 95%CI,P values and correlation coefficients. Data were grouped together according to each faecal marker,Crohn's disease or ulcerative colitis,and paediatric compared with adult study populations. Studies included in this review assessed mucosal inflammation by endoscopic and/or histological means and compared these findings to faecal marker concentrations in inflammatory bowel diseases(IBD) patient cohorts. Articles had to be published between 1990 and February 2015 and written in English. Papers excluded from the review were those where the faecal biomarker concentration was compared between patients with IBD and controls or other disease groups,those where serum biomarkers were used,those with a heterogeneous study population and those only assessing post-operative disease. RESULTS: The available studies show that faecal markers,such as calprotectin and lactoferrin,are promising non-invasive indicators of mucosal healing. However,due to wide variability in study design,especially with regard to the definition of mucosal healing and evaluation of marker cut offs,the available data do not yet indicate the optimal roles of these markers. Thirty-six studies published between 1990 and 2014 were included. Studies comprised variable numbers of study participants,considered CD(15-164 participants) or UC(12-152 participants) separately or as a combined group(11-252 participants). Eight reports included paediatric patients. Several indices were used to document mucosal inflammation,encompassing elevenendoscopic and eight histologic grading systems. The majority of the available reports focused on faecal calprotectin(33 studies),whilst others assessed faecal lactoferrin(13 studies) and one study assessed S100A12. Across all of the biomarkers,there is a wide range of correlation describing the association between faecal markers and endoscopic disease activity(r values ranging from 0.32 to 0.87,P values ranging from < 0.0001 to 0.7815). Correlation coefficients are described in almost all studies and are used more commonly than outcome measures such as sensitivity,specificity,PPV and/or NPV. Overall,the studies that have evaluated faecal calprotectin and/or faecal lactoferrin and their relationship with endoscopic disease activity show inconsistent results. CONCLUSION: Future studies should report the results of faecal inflammatory markers in the context of mucosal healing with clear validated cut offs. | Gudula JAM Boon Andrew S Day Chris J Mulder Richard B Gearry | 2015 | World Journal of Gastroenterology2015，21，40： | 4 |
| 3 | Chemical oxidation kinetics ofpyrite in bioleaching processes 显示文摘 | Boon M Heijnen J J | 1998 | Hydrometallurgy1998，，1： | 2 |
| 4 | Adjuvant therapy after curative resection for gastric cancer: Meta-analysis of randomized trials显示文摘 | Hermans J Bonenkamp JI Boon MC | 1993 | J Clin Oncol1993，11，： | 2 |
| 5 | 弓形虫感染引起小胶质细胞与神经元的接触以及细胞体周边抑制性突触丧失显示文摘大脑内的感染和炎症会引起神经元连通性和功能的改变。细胞内的原生动物寄生虫,弓形虫,是一种感染脑部的病原体,可引起脑炎和癫痫发作。这种寄生虫的持续感染还与行为改变和发生精神疾病(包括精神分裂症)的风险增加有关。目前来自人类和小鼠模型的研究证据表明,癫痫发作和精神分裂症均由抑制性突触的丧失或功能障碍引起。与此相符,我们最近报道了持续性弓形虫感染改变谷氨酸脱羧酶67(GAD67)的分布,该酶在抑制性突触中催化GABA的合成。这些变化可能反映突触前装置在抑制性神经元中的重新分布或抑制性神经末梢的丧失。为了直接评估后者的可能性,我们采用序列块面扫描电子显微镜(SBFSEM)并量化寄生虫感染后新皮质和海马中的细胞体周边抑制性突触。持续感染不仅导致明显的细胞体周边突触丧失,而且还诱导髓样来源的细胞对神经元细胞体的包封。免疫组织化学、遗传和超微结构分析显示,这些髓样来源的细胞包括活化的小胶质细胞。最后,超微结构分析确定了包膜于细胞体周围神经末梢的髓样来源的细胞,提示它们可能会主动置换或吞噬突触元件。因此,这些结果表明,活化的小胶质细胞有助于寄生虫感染后细胞体周围抑制突触损失,并对于弓形虫的持续感染可能如何导致癫痫发作和精神疾病提供了一种新的机制。 | Carrillo GL Ballard VA Glausen T Boone Z Teamer J Hinkson CL Wohlfert EA Blader IJ Fox MA 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，3： | 2 |
| 6 | The carboxyl-terminal part of the putative Berne virus polymerase is expressed by ribosomal frameshifting and contains sequence motifs which indicate that toro- and eoronaviruses are evolutionarily related 显示文摘 | Snijder E J den Boon J A Bredenbeek P J | 1990 | Nucleic Acids Res1990，18，： | 1 |
| 7 | ST Segment Depression Criteria and the Prevalence of Silent Cardiac Ischemia in Hypertensives显示文摘 | Boon D Goudoever J Piek J | 2003 | Hypertension2003，41，3： | 1 |
| 8 | Comparative evaluation of building responses to an adjacent braced excavation显示文摘 | BOONE S J WESTLAND J NUSINK R | 1999 | Canadian Geotechnical Journal1999，36，2： | 1 |
| 9 | Chemical oxidation kinetics of pyrite in bioleaching processes显示文摘 | Boon M Heijnen J J | 1998 | Hydrometallurgy1998，48，1： | 1 |
| 10 | Hydrodesulfurization studies with a single -layer molybdenum disulfite catalyst 显示文摘 | Boone W P Ekerdt J G | 2000 | Journal of Catalysis2000，193，： | 1 |
| 11 | Cis-l,4-poly-β-myrcene: The structure of the polymeric fraction of mastic resin elucidated显示文摘 | Berg K J Horst J Boon J J | 1998 | TetrahedronLetters1998，39，： | 1 |
| 12 | The deter- minants of corporate board size and composition: an empirical analysis 显示文摘 | BOONE A FIELD L KARPOFF J | 2007 | Journal of Financial Economics2007，85，1： | 1 |
| 13 | Temporal and Spatial Analysis of Sin Nombre Virus Quasispecies in Naturally Infected Rodents显示文摘 | Feuer R Boone J D Netski D | 1999 | J Virol1999，73，11： | 1 |
| 14 | The adipose conversion process:regulation by extracellular and intracellular factors显示文摘 | Boone C Mourot J Gregiore F | 2000 | Reprod Nutr Dev2000，40，： | 1 |
| 15 | River Conservation and Management显示文摘 | P J Boon P Calow G E Petts | 1992 | John Wiley & Sons1992，，： | 1 |
| 16 | Mast cells are the main interleukin-17-positive cells in anti-citrullinated protein antibody-positive and negative rheumatoid arthritis and osteoarthritis aynovium显示文摘 | Suurmond J Dorjee AL Boon MR | 2011 | Arthritis Res Ther2011，13，5： | 1 |
| 17 | Competitive intelligence in support ofstrategic training and learning 显示文摘 | BOTHA D F BOON J A | 2008 | SAJIM : South African Jour-nal of Information Management2008，10，3： | 1 |
| 18 | Size effects of PVP Pd nanoparticles on the catalytic Suzuki reactions inaqueous solution显示文摘 | Li Y Boone E J *'1-Sayed M A | 2002 | Langmuir2002，18，12： | 1 |
| 19 | Plant and soil responses to three years of chronic nitrogen additions at the Harvardforest, Massachusetts显示文摘 | Aber J D Mcdowell W H Boone R | 1993 | Ecological Applications1993，3，1： | 1 |
| 20 | Synthe- sis of LD-Hepp and Kdo containing di- and tetrasac- charide derivatives of Neisseriu meningitidis inner-core region via iodonium ion promoted glycosidations 显示文摘 | Boons G J Van D F L Vander K P M | 1992 | Tetrahedron1992，48，5： | 1 |
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