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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Polymorphous lighteruption:A clinical,photobiologic,and follow-up study of l10 patients显示文摘 | Boonstra HE van Weelden H Toonstra J | 2000 | J Am Acad Dermatol2000，42，21： | 1 |
| 3 | The influence of the pretrestment of powder on the resulting properties of LaNi5 electrodes显示文摘 | Boonstra A H Bernards T M N | 1990 | J Less Common Metals1990，161，2： | 1 |
| 4 | Exercise testing to estimate survival in pulmonary hypertension 显示文摘 | Groepenhoff H Vonk-Noordegraaf A Boonstra A | 2008 | Med Sci Sports Exerc2008，40，： | 1 |
| 5 | Polymorphous light eruption: A clinical, photobiologic, and follow-up study of 110 patients显示文摘 | van Weelden H Toonstra J | 2000 | J Am Acad Dermatol2000，42，21： | 1 |
| 6 | The role of cytokines in uhraviolet-- B induced immunosuppression显示文摘 | Boonstra A Savelkonl H | 1997 | Eur Cytokine Netw1997，8，2： | 1 |
| 7 | The dependence of the gelatin time on the hydrolysis time in a two-step SiO2 Sol-gel process显示文摘 | Boonstra A H Bemards T N M | 1998 | J Non-Cryst Solids1998，105，： | 1 |
| 8 | Antipsychotic prophy- laxis is needed after remission from a first psychotic episode in schizophrenia patients: results from an aborted randomised trial 显示文摘 | Boonstra G Burger H Grobbee DE et at | 2011 | Int J Psychiatry Clin Pract2011，15，2： | 1 |
| 9 | Reduced insulin sensitivity and the presence of cardiovascular risk factors in short prepubertal children born small for gestational age(SGA)显示文摘 | Arends N J Boonstra V H Duivenvoorden H J | 2005 | Clin Endocrinol2005，62，1： | 1 |
| 10 | Reinforcement of silicone rubber by particulate silica 显示文摘 | Boonstra B B C H Dannenberg E M | 1975 | Rubber Chemistry and Tech- nology1975，48，4： | 1 |
| 11 | Relation between the photoadsorption of oxygen and the number of hydroxyl groups on a titanium dioxide surface 显示文摘 | Boonstra A H Mutsaers C A H A | 1975 | The Journal of Physical Chemistry1975，79，16： | 1 |
| 12 | A measurement of carbon black pellet quality and significance显示文摘 | Boonstra B B Atkins J H | 1966 | Rubber Chem Technol1966，39，4： | 1 |
| 13 | Efficacy and safety of methylphenidate in 45 adults with attention deficit/ hyperactivity disorder:a randomized placebo controlled double blind crossover trial 显示文摘 | Kooij J J S Burger H Boonstra A M | 2004 | Psychol Med2004，34，6： | 1 |
| 14 | Carbon black for highly conductive rubber显示文摘 | Policy M H Boonstra B B S T | 1957 | Rubber Chemistry and Technology1957，30，1： | 1 |
| 15 | The effect of formamide on silica sol-gel processes显示文摘 | Boonstra A H Bernards T N M Smits J J T | 1989 | J Non-Cryst Solids1989，109，23： | 1 |
| 16 | Characterisation of thermally modified wood:molecular reasons for wood performance improvement显示文摘 | Tjeerdsma BF Boonstra M Pizzi A Tekely P Militz H | 1998 | Holz Rob-und Werkstoff1998，56，3： | 1 |
| 17 | Gait disor- ders and balance disturbances in Parkinson's disease: clinical update and pathophysiology 显示文摘 | Boonstra TA van der Kooij H Munneke M | 2008 | Curr Opin Neurol2008，21，4： | 1 |
| 18 | Validation of a LightCycler-based reverse transeription polymerase chain reaction for the detection of foot-and-mouth disease virus 显示文摘 | Moonen P Boonstra J Van D H R H | 2003 | Virol Methods2003，113，1： | 1 |
| 19 | MEG-compatible force sensor 显示文摘 | Boonstra T W Clairbois H E Daffertshofer A | 2005 | Journal of Neuroscience Methods2005，144，： | 1 |
| 20 | 显示文摘 | Lippits G J M Bernards T N M | 1989 | J Less-CommonMetals1989，155，： | 1 |
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