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| 1 | Chemokine and chemotactic signals in dendritic cell migration显示文摘Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation of specific T-cell responses and for thedevelopment of immune tolerance. Immature DCs reside in peripheral tissues and specialize in antigen capture, whereas matureDCs reside mostly in the secondary lymphoid organs where they act as antigen-presenting cells. The correct localization of DCs isstrictly regulated by a large variety of chemotactic and nonchemotactic signals that include bacterial products, DAMPs (dangerassociated molecular patterns), complement proteins, lipids, and chemokines. These signals function both individually and inconcert, generating a complex regulatory network. This network is regulated at multiple levels through different strategies, such assynergistic interactions, proteolytic processing, and the actions of atypical chemokine receptors. Understanding this complexscenario will help to clarify the role of DCs in different pathological conditions, such as autoimmune diseases and cancers and willuncover new molecular targets for therapeutic interventions. | Laura Tiberio Annalisa Del Prete Tiziana Schioppa Francesca Sozio Daniela Bosisio Silvano Sozzani | 2018 | Cellular & Molecular Immunology2018，15，4： | 14 |
| 2 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 3 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 4 | Differential expression and regulation of toll-like receptors (TLR) in human leukocytes:selective expression of TLR3 in dendritic cells显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | J Immunol2000，164，11： | 1 |
| 5 | Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells 显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | The Journal of Immunology2000，164，11： | 1 |
| 6 | Differential expres- sion and regulation of toll-like receptors (TLR) in human leukoeytes: selective expression of TIAL3 indendritic ceils 显示文摘 | MUZIO M BOSISIO D POLENTARUTYI N | 2000 | J Immunol2000，164，： | 1 |
| 7 | Biflavones of Ginkgo biloba stimulate lipolysis in 3T3-L1 adipocytes显示文摘 | Dell'Agli M Bosisio E | 2002 | Planta Med2002，68，1： | 1 |
| 8 | Toll-like receptor family and signalling pathway 显示文摘 | Muzio M Polentarutti N Bosisio D | 2000 | Biochem Soc Trans2000，28，5： | 1 |
| 9 | Six-port direct digital receiver (SPDR) and standard direct receiver (SDR) results for QPSK modulation at high speeds显示文摘 | Jean-Christophe Schiel Serioja Ovidiu Tatu Ke Wu Rcanato G Bosisio | 2002 | IEEE MIT-S Digest2002，，： | 1 |
| 10 | Vasular effects of wine polyphenols显示文摘 | DELL'AGLI M BUSCIAL A BOSISIO E | 2004 | Cardiovasc Res2004，63，： | 1 |
| 11 | Differential expression and regulation of toil-like receptors (TLR) in human leukocytes:selective expression of TLR3 in dendritic cells显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | J Immunol2000，164，11： | 1 |
| 12 | On the measurement of thickness of ice layers on power transmission lines显示文摘 | Xu Y Bosisio R | 2007 | SensImaging2007，8，2： | 1 |
| 13 | Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes:selective expression of TLR3 in dendritic cells显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | J Immunol2000，164，11： | 1 |
| 14 | Pharmacological activities of Chelidoni- um majus L (Papaveraceae) 显示文摘 | Colombo M L Bosisio E | 1996 | Pharmacol Res1996，33，2： | 1 |
| 15 | Goubau Ice Sensor Transitions for Electric Power Lines显示文摘 | Xu Y Bosisio R | 2009 | Senslmaging2009，10，12： | 1 |
| 16 | An alterative explicit six-port matrix calibration formalism using five standards显示文摘 | Ghannouchi F M Bosisio R G | 1988 | IEEE Transactions on Microwave Theory and Techniques1988，36，3： | 1 |
| 17 | W-band muhiport sub- strate-integrated waveguide circuits 显示文摘 | Moldovan E Bosisio R G Wu K | 2006 | IEEE Trans on Microwave Theory and Techniques2006，54，2： | 1 |
| 18 | The sixport reflectometer and its complete calibration by four standard terminations显示文摘 | Ghannouchi F M Bosisio R G | 1988 | Microwaves Antennas and Propagation IEE Proceedings1988，135，4： | 1 |
| 19 | Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes:Selective Expression of TLR3 in Dendritic Cells显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | The Journal of Immunology2000，164，： | 1 |
| 20 | Computer and measurement simulation of a new digital receiver operating directly at millimeter-wave frequencies显示文摘 | J Li R G Bosisio K Wu | 1995 | IEEE Transactions on Microwave Theory and Techniques1995，43，12： | 1 |
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