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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Air flow obstruction,dyspnea,exercise performance(BODE) index jn chronic obstruction pulmonary diseases显示文摘 | CeUi BR Cote C Marin JM | 2004 | N Engl J Med2004，350，10： | 1 |
| 3 | Tissuespecific knock-out of the insulin receptor in pancreatic βcells creates an insulin secretory defect similar to that in type2 diabetes显示文摘 | Kulkaarni R N Brüning J C Winnary J N | 1999 | Cell1999，96，： | 1 |
| 4 | Inferring 3D models from freehand sketches and constraints显示文摘 | Eggli L Hsu C Y Brüderlin B D | 1997 | Computer-aided Design1997，29，2： | 1 |
| 5 | Reticulated platelets predict platelet count recovery following chemotherapy显示文摘 | Wang C Smith BR Ault KA | 2002 | Transfusion2002，42，3： | 1 |
| 6 | The putative neural stem cell marker,nestin,is expressed in heterogeneous cell types in the adult rat neocortex显示文摘 | Ernst C Christit BR | | 0，，： | 1 |
| 7 | Biochemical hallmarks of tyrosine hydroxylase deficiency显示文摘 | Br(a)utigam C Wevers RA Jansen RJ | | 0，，： | 1 |
| 8 | Effect of thyroxinereplacement on serum IGF-I,IGFBP-3and the acid-labile sub-unit in patients with hypothyroidism and hypopituitarism显示文摘 | Schmid C Zwimpfer C Br ndle M | 2006 | Clin Endocrinol(Oxf)2006，65，6： | 1 |
| 9 | Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers显示文摘 | Mancini-Bourgine M Fontaine H Bréchot C | | Vaccine0，，： | 1 |
| 10 | Monitoring the structure and dynamics of a dense moist evergreen forest in the Western Ghats(Kodagu District,Kernataka,India)显示文摘 | Elouard C Pascal J-P Pelissier R Ramesh BR Houllier F Durand M Aravjy S Moravie M-A Gimaret-Carpentier | | 0，，02： | 1 |
| 11 | Tyrosine hydroxylase deficiency causes progressive encephalopathy and dopa-nonresponsive dystonia显示文摘 | Hoffmann GF Assmann B Br(a)utigam C | | 0，，6： | 1 |
| 12 | Distinct contri-butions of human hippocampal theta to spatial cognitionand anxiety显示文摘 | Cornwell BR Arkin N Overstreet C | 2012 | Hippocampus2012，22，9： | 1 |
| 13 | Tidal breathing flow-volume loops in bronchiolitis in infancy:the effect of albuterol显示文摘 | Totapally BR Demerci C Zureikat G | 2002 | Crit Care2002，6，2： | 1 |
| 14 | The body-mass index,airflow obstruction,dyspnea,and exercise capacity index in chronic obstructive pulmonary disease显示文摘 | Celli BR Cote CG Marin JM Casanova C Montes de Oca M Mendez RA Pinto Plata V Cabral HJ | 2004 | N Engl J Med2004，350，10： | 1 |
| 15 | Burden of disease: implications for future search显示文摘 | Michaud CM Murray C J Bloom BR | 2001 | JAMA2001，285，5： | 1 |
| 16 | Ventricular enlargement in schizophrenia related to volume reduction of the thalamus, striatum, and superior temporal cortex显示文摘 | Gaser C Nenadic I Buchsbaum BR | 2004 | Am J Psychiatry2004，161，1： | 1 |
| 17 | A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy 显示文摘 | Stroll BR Migliorini C Kadambi A | 2003 | Blood2003，102，7： | 1 |
| 18 | Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease显示文摘 | Richards TJ Eggebeen A Gibson K Yousem S Fuhrman C Gochuico BR | 2009 | Arthritis Rheum2009，60，： | 1 |
| 19 | The isolation and properties of antimycin A 显示文摘 | Dunshee BR Leben C Keitt GW | 1949 | J Am Chem Soc1949，71，7： | 1 |
| 20 | Impairment of mitogenic activation of peripheral blood lymphocytes in Alzheimer's disease显示文摘 | Stieler JT Lederer C Brückner MK | 2001 | Neuroreport2001，12，18： | 1 |
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