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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Thermally Nitrided Stainless Steels for Polymer Electrolyte Membrane Fuel Cell Bipolar Plates Part 1:Model Ni-50Cr and Austenitic 349TM Alloys显示文摘 | Brady M P Teeter G | 2004 | Journal of Power Sources2004，138，： | 1 |
| 3 | Radiotheray for caurcinoma of bladder显示文摘 | Petrovich Z Jozsef G Brady LW | 2001 | Am J Clin Oncol2001，24，1： | 1 |
| 4 | Construction of cDNA libraries from single cells显示文摘 | Brady G Iscove N N | 1993 | Method Enzymol1993，225，： | 1 |
| 5 | Assessing the effects of quality,value,and customer satisfaction on consumer behavioral intentions in service environment显示文摘 | CRONIN J J BRADY M K HULT G T M | | 0，，02： | 1 |
| 6 | Assessing the Effects of Quality, Value, and Customer Satisfaction on Consumer Behavioral Intentions in Service Environment 显示文摘 | Cronin J J Brady M K Hult G T M | 2000 | Journal of Retailing2000，，2： | 1 |
| 7 | Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1 显示文摘 | Brady G Boggan L Bowie A | 2005 | J Biol Chem2005，280，30： | 1 |
| 8 | Thermally Nitrided Stainless Steels for Polymer Electrolyte Membrane Fuel Cell Bipolar Plates Part 2:Beneficial Modification of Passive Layer on AISI446显示文摘 | Brady M P Teeter G | 2004 | Journal of Power Sources2004，138，： | 1 |
| 9 | Thermally nitrided stainless steels for polymer electrolyte membrane fuel cell bipolar plates Part l: Model Ni-50Cr and austenitic 349TM alloys 显示文摘 | WANG H BRADY M P TEETER G | 2004 | Journal of Power Sources2004，138，： | 1 |
| 10 | Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells显示文摘 | Scholler J Brady TL Binder-Scholl G | 2012 | Sei Transl Med2012，4，132： | 1 |
| 11 | The effect of carben fiber Orientaion on the fatigue resistance and bending properties of two denture resin显示文摘 | J Deboer S G Wermilyea R E Brady | | 0，，： | 1 |
| 12 | Nivolumab in Previously Un- treated Melanoma without BRAF Mutation显示文摘 | Robert C Long G V Brady B | 2015 | N Engl J Med2015，372，4： | 1 |
| 13 | Decade-long safety and function ofretroviral-modified chimeric antigen receptor T cells显示文摘 | Scholler J Brady TL Binder-Scholl G | 2012 | Sci Transl Med2012，4，13： | 1 |
| 14 | Nivolumab in previously untreated melanoma without BRAF mutation 显示文摘 | Robert C Long G V Brady B | 2015 | N Engl J Med2015，372，4： | 1 |
| 15 | The boundary element method for determining stresses and displacement around long opening in a triaxial stress field显示文摘 | BRAY J W | 1978 | International Journal of Rock Mechanics and Mining Science & Geomechanics Abstracts1978，15，1： | 1 |
| 16 | Assessing the effects of quality,value and customer satisfaction on consumer behavioral intentions in service environments显示文摘 | Cronin J J Jr Brady M K Hult G T M | 2000 | Journal of Retailing2000，76，2： | 1 |
| 17 | Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D显示文摘 | Brady G Boggan L Bowie A | 2005 | J Biol Chem2005，280，30： | 1 |
| 18 | Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1(IL-1) involves MyD88,IL-1 receptor-associated kinase 1,TRAF-6,and Rac1显示文摘 | Jefferies C Bowie A Brady G | 2001 | Mol Cell Biol2001，21，14： | 1 |
| 19 | Alloy design strategies for promoting protective oxide-scale formation显示文摘 | Brady M P Wrigt I G Gleeson B | 2000 | JOM2000，52，1： | 1 |
| 20 | Radiative falloff in Schwarzschild-de Sitter spacetime显示文摘 | BRADY P R CHAMBERS C M LAARAKKERS W G POISSON E | 1999 | Phys Rev D1999，60，06： | 1 |
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