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| 1 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 2 | role of microRNAs in the main molecular pathways of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignant neoplasia. HCC is characterized by a poor prognosis. The need to find new molecular markers for its diagnosis and prognosis has led to a progressive increase in the number of scientific studies on this topic. MicroRNAs(miRNAs) are small noncoding RNA that play a role in almost all main cellular pathways. miRNAs are involved in the regulation of expression of the major tumor-related genes in carcinogenesis, acting as oncogenes or tumor suppressor genes. The aim of this review was to identify papers published in 2017 investigating the role of miRNAs in HCC tumorigenesis. miRNAs were classified according to their role in the main molecular pathways involved in HCC tumorigenesis:(1) m TOR;(2) Wnt;(3) JAK/STAT;(4) apoptosis; and(5) MAPK. The role of miRNAs in prognosis/response prediction was taken into consideration. Bearing in mind that the analysis of miRNAs in serum and other body fluids would be crucial for clinical management, the role of circulating miRNAs in HCC patients was also investigated. The most represented mi RNA-regulated pathway in HCC is m TOR, but apoptosis, Wnt, JAK/STAT or MAPK pathways are also influenced by mi RNA expression levels. These miRNAs could thus be used in clinical practice as diagnostic, prognostic or therapeutic targets for HCC treatment. | Francesco Vasuri Michela Visani Giorgia Acquaviva Thomas Brand Michelangelo Fiorentino Annalisa Pession Giovanni Tallini Antonia D’Errico Dario de Biase | 2018 | World Journal of Gastroenterology2018，24，25： | 16 |
| 3 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 4 | Phase Ⅱ trial of tesmilifene plus mitoxantrone and prednisone for hormne refractory prostate cancer:High subjective and objective response in patients with symptomatic metastases显示文摘 | Raghavan D Brandes LJ Klapp K | 2005 | J Urol2005，174，： | 1 |
| 5 | Dimension reduction and souce identification for multispecies groundwater contamination显示文摘 | Duffy C J Brandes D | 2001 | Journal of Contaminant Hydrology2001，48，： | 1 |
| 6 | Development of abionematicide with Paecilomyces lilacinus to control Meloid-ogyne incognita 显示文摘 | Brand D Roussos S Pndey A | 2004 | Applied Biochemistry and Biotechnolo-gy2004，118，1： | 1 |
| 7 | Abiotic nitrogen reduction on the early Earth显示文摘 | BRANDES J A BOCTOR N Z CODY G D | 1998 | Nature1998，395，： | 1 |
| 8 | Pigment production by Monascus purpureus in grape waste using {hctorial design 显示文摘 | Silverira S T Daroit D J Brandeli A | 2008 | LWT - Food Science and Technology2008，41，1： | 1 |
| 9 | Modification of Cu/ZnO/SiO2 cata- lysts by high temperature reduction 显示文摘 | Poels E K Brands D S | 2000 | Applied Catalysis A : General2000，191，12： | 1 |
| 10 | Pelvic muscle and acetabular contact forces during gait 显示文摘 | PEDERSEN D R BRAND R A DAVY D T | 1997 | J giomech1997，30，9： | 1 |
| 11 | Mechanism of the selective catalytic reduction of NO by NH3 over MNOx/Al2O3 显示文摘 | Kijlstra W S Brands D S Smit H I | 1997 | Journal of Catalysis1997，171，2： | 1 |
| 12 | The humane collection of fetal bovine 8erunl and possibilities for serum-free cellandtissue culture显示文摘 | Van der Valk J MeRor D Brands R | 2004 | Toficdogyin Vitro2004，18，1： | 1 |
| 13 | Mechanism of the selective catalytic reduction of NO by NH3 over MnO,/AI203 显示文摘 | Kijlstra W S Brands D S Poels E K | 1997 | Journal of Catal1997，171，1： | 1 |
| 14 | A dynamic wind farm aggregate model for the simulation of power fluctuations due to wind turbulence显示文摘 | Tommasi L D Gibescu M Brand A J | 2010 | Journal of Computational Science2010，1，2： | 1 |
| 15 | Impact of renin- angiotensin-aldosterone blockade by angiotensin-converting enzyme inhibitors or AT-1 blockers on frequency of contrast medium-induced nephropathy: a post-hoc analysis from the Dialysis-Versus-Diuresis (DVD) trial 显示文摘 | Kiski D Stepper W Brand E | 2010 | Nephrol Dial Transplant2010，25，3： | 1 |
| 16 | Association between mitochondrial dysfunction and severity and outcome of septic shock 显示文摘 | Brealey D Brand M Hargreaves I | 2002 | Lancet2002，360，9328： | 1 |
| 17 | Achilles tendonitis in runners:a report of five cases显示文摘 | Clancy WG Jr Neidhard D Brand RL | | 0，，02： | 1 |
| 18 | Synthesis and self-assembly of functionalized hexa-peri-hexabenzocoronenes 显示文摘 | ITO S WEHMEIER M BRAND J D | 2000 | Chem Eur J2000，6，23： | 1 |
| 19 | An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited by type Ⅱ collagen显示文摘 | Brand D Myers L | 1997 | J Exp Med1997，185，6： | 1 |
| 20 | Beneficial cardiovascu-lar effects of endothelin ET(A)receptor blockade in establishedlong-term heart failure after myocardial infarction显示文摘 | Vetter D Shaw S G Brandes R P | 2006 | Exp BiolMed2006，231，6： | 1 |
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