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| 1 | MICROBE-METAL-INTERACTIONS FOR THE BIOTECHNOLOGICAL TREATMENT OF METAL-CONTAINING SOLID WASTE显示文摘In nature, microbes are involved in weathering of rocks, in mobilization of metals from minerals, and in metal precipitation and deposition. These microbiological principles and processes can be adapted to treat particulate solid wastes. Especially the microbiological solubilization of metals from solid minerals (termed bioleaching) to obtain metal values is a well-known technique in the mining industry. We focus here on non-mining mineral wastes to demon- strate the applicability of mining-based technologies for the treatment of metal-containing solid wastes. In the case study presented, microbial metal mobilization from particulate fly ash (originating from municipal solid waste incineration) by Acidithiobacilli resulted in cadmium, copper, and zinc mobilization of >80%, whereas lead, chromium, and nickel were mobilized by 2, 11 and 32%, respectively. In addition, the potential of HCN-forming bacteria (Chromobacterium violaceum, Pseudomonas fluorescens) was investigated to mobilize metals when grown in the presence of solid materials (e.g., copper-containing ores, electronic scrap, spent automobile catalytic converters). C. violaceum was found capable of mobilizing nickel as tetracyanonickelate from fine-grained nickel powder. Gold was microbially solubilized as dicyano- aurate from electronic waste. Additionally, cyanide-complexed copper was detected during biological treatment of shredded printed circuit-board scraps. Water-soluble copper and platinum cyanide were also detected during the treat- ment of spent automobile catalytic converters. | Helmut Brandl Mohammad A. Faramarzi | 2006 | China Particuology2006，4，2： | 7 |
| 2 | Computer-munching microbes: metal leaching from electronic scrap by bacteria and fungi显示文摘 | H Brandl R Bosshard M Wegmann | 2001 | Hydrometallurgy2001，，2： | 3 |
| 3 | FunGeneClusterS: Predicting fungal gene clusters from genome and transcriptome data显示文摘Introduction:Secondary metabolites of fungi are receiving an increasing amount of interest due to their prolific bioactivities and the fact that fungal biosynthesis of secondary metabolites often occurs from co-regulated and co-located gene clusters.This makes the gene clusters attractive for synthetic biology and industrial biotechnology applications.We have previously published a method for accurate prediction of clusters from genome and transcriptome data,which could also suggest cross-chemistry,however,this method was limited both in the number of parameters which could be adjusted as well as in userfriendliness.Furthermore,sensitivity to the transcriptome data required manual curation of the predictions.In the present work,we have aimed at improving these features.Results:FunGeneClusterS is an improved implementation of our previous method with a graphical user interface for off-and on-line use.The new method adds options to adjust the size of the gene cluster(s)being sought as well as an option for the algorithm to be flexible with genes in the cluster which may not seem to be co-regulated with the remainder of the cluster.We have benchmarked the method using data from the well-studied Aspergillus nidulans and found that the method is an improvement over the previous one.In particular,it makes it possible to predict clusters with more than 10 genes more accurately,and allows identification of co-regulated gene clusters irrespective of the function of the genes.It also greatly reduces the need for manual curation of the prediction results.We furthermore applied the method to transcriptome data from A.niger.Using the identified best set of parameters,we were able to identify clusters for 31 out of 76 previously predicted secondary metabolite synthases/synthetases.Furthermore,we identified additional putative secondary metabolite gene clusters.In total,we predicted 432 co-transcribed gene clusters in A.niger(spanning 1.323 genes,12%of the genome).Some of these had functions related to primary metabolism,e.g.we have identified a cluster for biosynthesis of biotin,as well as several for degradation of aromatic compounds.The data identifies that suggests that larger parts of the fungal genome than previously anticipated operates as gene clusters.This includes both primary and secondary metabolism as well as other cellular maintenance functions.Conclusion:We have developed FunGeneClusterS in a graphical implementation and made the method capable of adjustments to different datasets and target clusters.The method is versatile in that it can predict co-regulated clusters not limited to secondary metabolism.Our analysis of data has shown not only the validity of the method,but also strongly suggests that large parts of fungal primary metabolism and cellular functions are both co-regulated and co-located. | Tammi C.Vesth Julian Brandl Mikael Rodam Andersen | 2016 | Synthetic and Systems Biotechnology2016，1，2： | 2 |
| 4 | POLY (β-HYDROXYALKANOATES): NATURAL BIOCOMPATIBLE AND BIODEGRADABLE POLYESTERS PRODUCED BY BACTERIA显示文摘A wide variety of different types of microorganisms are known to produce intracellular energy and carbon storage products, which have been generally described as being poly (β-hydroxybutyrate), PHB, but which are, more often than not, copolymers containing different alkyl groups at the β-position. Hence, PHB belongs to the family ofpoly (β-hydroxyalkanoastes), PHA, all of which are usually formed as intracellular inclusions in bacteria under unbalanced growth conditions. Recently, it became of industrial interest to evaluate these PHA polyesters as natural biodegradable and biocompatible plastics for a wide range of possible applications, such as surgical sutures or packaging containers. For industrial applications, the controlled incorporation of repeating units with different chain lengths into a series of copolymers is desirable in order to produce polyesters with a range of material properties because physical and chemical characteristics depend strongly on the polymer composition. Such 'tailor-made' copolymers can be produced under controlled growth conditions in that, if a defined mixture of substrates for a certain type of microorganisms is supplied, a well defined and reproducible copolymer is formed. | ROBERT W. LENZ RICHARD A. GROSS HELMUT BRANDL R. CLINTON FULLER | 1989 | Chinese Journal of Polymer Science1989，7，4： | 2 |
| 5 | Subtype-selective antagonists of lysophosphatidic acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques显示文摘 | ROTHER E BRANDL R BAKER D L | 2003 | Circulation2003，108，6： | 2 |
| 6 | Net photosynthesis,electron transport capacity,and ultrastructure of pisum sativum Lexposed to ultraviolet-B radiation 显示文摘 | Brandle J K Campbell W F Sisson W B | 1977 | Plant Physiol1977，60，： | 1 |
| 7 | Pleuromutilins:fermentation,structure and biosynthesis显示文摘 | Knauseder F Brandl E | 1976 | The Journal of Antibiotics1976，29，2： | 1 |
| 8 | Liraglutide,a once-daily human GLP-1 analogue,added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes(LEAD-1 SU)显示文摘 | Marre M Shaw J Brandle M | 2009 | Diabiet Med2009，26，3： | 1 |
| 9 | Impact of throid dysfunction on serum cystatin C显示文摘 | Fricker M Wiesli P Brandle M | 2003 | Kidney Int2003，63，5： | 1 |
| 10 | Geographical diversity, parentalselection and heterosis in oilseed rapes显示文摘 | Brandle JE Mc Vetty PBE | 1990 | Canadian Journal of Plant- Science1990，70，： | 1 |
| 11 | The cost- effectiveness of lifestyle modification or metformin in preventing type 2 diabetes in adults with impaired glucose tolerance 显示文摘 | Herman WH Hoerger TJ Brandle M | 2005 | Ann Intern Med2005，142，5： | 1 |
| 12 | Three-dimensional aerodynamic structure of a tree shelterbelt:definition,characterization and working models显示文摘 | Zhou X H Brandle J R Mize C W | | 0，，02： | 1 |
| 13 | Temporal progress in improving carbon and nitrogen storage by grazing exclosure practice in a degraded land area of China’s Horqin sandy grassland显示文摘 | Li Y Zhou X Brandle J R | 2012 | Agriculture Ecosystems&Environment2012，159，： | 1 |
| 14 | Gearbox Noise Reduction显示文摘 | Brandl F | 2005 | International Vehicle NVH Conference2005，3229，： | 1 |
| 15 | Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits显示文摘 | Brandl K Plitas G Mihu CN | 2008 | Nature2008，455，7214： | 1 |
| 16 | Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1mutation disrupting the ATF6-driven unfolded protein response显示文摘 | Brandl K Rutschmann S Li X | 2009 | Proc Natl Acad Sci U S A2009，106，9： | 1 |
| 17 | Finite Groups Whose Elements Order are Consecutive Integers显示文摘 | BRANDL SHI WUJIE | 1991 | J Alg1991，143，2： | 1 |
| 18 | Geographical diversity, pa- rental selection and heterosis in oilseed rape显示文摘 | Brandle J E Mc Vetty P B E | 1990 | Canadian Journal of Plant Science1990，70，： | 1 |
| 19 | Aspects of plant behavior un- der anoxia and post-anoxia 显示文摘 | Pfister S M Brandle R | 1994 | Proceedings of the Royal Society of Edinburgh1994，，： | 1 |
| 20 | Integrating internet-based reading materials into the foreign language curriculum: From teacher-to-student-centered approaches 显示文摘 | Brandle K | 2002 | Language Learning & Technology2002，，3： | 1 |
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