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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | Phosphorus-31 nuclear magnetic resonance spectroscopic determination of phytate in foods显示文摘 | Eugene P M Brian Q P Barbara F H | 1986 | Journal of Agricultural and Food Chemistry1986，34，1： | 1 |
| 3 | Combined optimal/classical approach to robust missile antopilot design显示文摘 | Wells Brian H Zarehan Paul | 1979 | Journal of Guidance and Control1979，4，3： | 1 |
| 4 | Validation of a sensitive LC-MS assay for quantification of glyburide and its metabolite 4-Wanshydroxy glyburide in plasma and urine: an OPRU Network study original research article显示文摘 | SURESH B N BRIAN J K MARY F H | 2007 | Journal of Chromatography B2007，860，1： | 1 |
| 5 | A Study on the Optimization of Integral Fuel Burnable Absorbers Using the Genetic Algorithm Based CIGARO Fuel Management System显示文摘 | Brian V H Madeline A F | 1997 | Ann Nucl Energy1997，24，6： | 1 |
| 6 | Removal of perennial ryegrass from overseeded bermudagrass using cultural methods显示文摘 | Brian B H Yelverton F H | 2001 | Crops Science2001，41，1： | 1 |
| 7 | A structured modeling approach for dynamic hybrid fuzzy-first principles models 显示文摘 | Pascal F Ben H Brian R | 2002 | Journal of Process Control2002，，12： | 1 |
| 8 | Synthesis of Highly Ordered,Three-Dimensional,Macroporous Structures of Amorphous or Crystalline Inorganic Oxides,Phosphates,and Hybrid Composites显示文摘 | Brian T H Christopher F B Thang D | 2004 | Chem Mater2004，16，11： | 1 |
| 9 | Geiger- Mode Avalanche Photodiodes for Three - Dimensional Imaging 显示文摘 | Brian F Aull Andrew H Loomis Douglas J Young | 2002 | Lincoln Laboratory Journal2002，13，2： | 1 |
| 10 | Biogeochemical tracers of the marine cyanobacterium Trichodesmium 显示文摘 | Carpenter E J Harvey H R Brian F | 1997 | DeepSea Research Part I1997，44，： | 1 |
| 11 | General synthesis of periodic macroporous solids by templated salt precipitation and chemical conversion显示文摘 | HONGWEI Y CHRISTOPHER F B BRIAN T H | 2000 | Chem Mater2000，12，： | 1 |
| 12 | Regulation of arabidopsis root development by nitrate availability 显示文摘 | Zhang H M Brian G F | 2000 | J Exp Bot2000，51，342： | 1 |
| 13 | Impact of TortuousGeometry on Laminar Flow Heat Transfer in Microchannels显示文摘 | DAI Z DAVID F F BRIAN S H | 2015 | International Journal of Heat and Mass Transfer2015，83，： | 1 |
| 14 | Geiger-mode avalanche photodiodes for three-dimensional imaging 显示文摘 | Brian F Aull Andrew H Loomis Douglas J Young | 2002 | Lincoln Laboratory Journal2002，13，2： | 1 |
| 15 | Low-Reynolds number heat transfer enhancement in sinusoidal channels显示文摘 | NATHAN R R DAVID F F BRIAN S H | 2007 | Chemical Engineering Science2007，62，3： | 1 |
| 16 | High yield synthesis of Ru-Pt mixed-metal cluster compounds 显示文摘 | Sophie H Tetyana K Brian F | 2001 | J Chem Soc Dalton Trans2001，，21： | 1 |
| 17 | Geiger-Mode Avalanche Photodiodes for Three-Dimensional Imaging 显示文摘 | Brian F Aull Andrew H Loomis Douglas J Young | 2002 | Lincoln Laboratory Journal2002，13，2： | 1 |
| 18 | Matrix and fiber influences on the cryogenic micro cracking of carbon fiber/epoxy composites显示文摘 | John F T Matthew S T Brian S H | 2003 | Composites Part A2003，41，： | 1 |
| 19 | NFIRE to TerraSAR X laser communication results satellite pointing,disturbances,and other attributes consistent with successful performance显示文摘 | Renny F Carl L Robert W Josef W David K John J Brian H Gerd M Wayne S Uwe S Ralph K Rolf M | 2009 | Proceedings of SPIE2009，7330，： | 1 |
| 20 | Information rich temporal virtual models using X3D显示文摘 | Robina H Brian F Steve P | | 0，，02： | 1 |
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