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	题名	作者	年代	出处	被引量
1	Proteomic analysis for developing new biomarkers of hepatocellular carcinoma显示文摘AIM: To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis. METHODS: Patients with liver cirrhosis of the three most frequent etiologies: hepatitis C virus, hepatitis B virus and alcoholic liver disease, were included in the study. The samples were analysed by 2D-electrophoresis in order to determine the differential protein expression. The proteins were separated according to the charge in immobilized pH 3-10 gradient strips and then by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Proteins of interest were excised, digested with trypsin and the resulting peptides were separated and identified. RESULTS: Three differentially expressed apolipoproteins (Apo) were identified based on the protein profile using proteomic techniques: Apo-A1, Apo-A4 and Apo-E. Apo-A4 levels were significantly lower in HCC than in non-HCC patients regardless of etiology (P < 0.01). Multivariate logistic regression showed that Apo-A4 and Apo-A1 were the only independent factors related to HCC diagnosis (P < 0.05). The receiver operating characteristic (ROC) curve including both Apo-A4 and Apo-A1 showed an area under the ROC of 0.944 (P < 0.001), a sensitivity of 0.89 and a specificity of 0.81 for diagnosis of HCC. CONCLUSION: Apo-A4 and Apo-A1 may be used clinically as biomarkers of HCC with a high sensibility and specificity. These findings may provide additional insights into the mechanism of HCC development and progression.	Maria Pleguezuelo Laura M Lopez-Sanchez Antonio Rodriguez-Ariza Jose L Montero Javier Briceno Ruben Ciria Jordi Muntane Manuel de la Mata	2010	World Journal of Hepatology2010，2，3：	3
2	Optimization of biodie sel production by sunflower oil transesterification显示文摘	Antoin G Tinaut F V Briceno Y	2002	Bioresource Technology2002，83，2：	1
3	Influence of marginal donors on liver preservation injury 显示文摘	Briceno J Marchal T Padillo J	2002	Transplantation2002，74，4：	1
4	Optimisation of biodiesel production by sunflower oil transesterification显示文摘	ANTOLIN G TINAUNT F V BRICENO Y		0，，02：	1
5	A combinatorial approach to materials discovery 显示文摘	XIANG X D SUN X BRICENO G LOU Y WANG K A CHANG H	1995	Science1995，268，17：	1
6	The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy显示文摘	Jacques AM Briceno N Messer AE	2008	Cardiovasc Res2008，79，3：	1
7	Behaviour of reference electrodes in the monitoring of corrosion potential at high temperature显示文摘	Navas M Gomez Briceno M D	1997	Nuclear Engineering and Design1997，168，1：	1
8	Molecular breeding for grain yield in barley : an evaluation of QTL effects in a spring barley cross显示文摘	Zhu H Briceno G Dovel R	1999	Theoretical and Applied Genetics1999，98，：	1
9	Carbamylated low - density lipoprotein induces oxidative stress and accelerated senescence in human endothelial progenitor cells 显示文摘	Carracedo J Merino A Briceno C	2011	FASEB J2011，25，13：	1
10	A class of cobalt oxide magnetoresistance materials discovered with combinatorial synthesis 显示文摘	Chang H Sun X D	1995	Science1995，270，：	1
11	A Combinatorial Ap- proach to Materials Discovery 显示文摘	Xiang X D Sun X D Briceno G	1995	Science1995，，268：	1
12	Influence of marginal donors on liver preservation injury显示文摘	Briceno J Marchal T Padillo J	2002	Transplantation2002，74，4：	1
13	Levels of amino acid neurotransmitters during mouse cerebellar neurogensis and in histostypic cerebellar cultures显示文摘	Miranda Contreras L Benitez Diaz P R Mendoza Briceno R V	1999	Dev Neurosci1999，21，2：	1
14	Do conversations with virtual avatars increase feelings of social anxiety 显示文摘	Powers MB Briceno NF Gresham R	2013	Jmirnal of Anxiety Disorders2013，27，4：	1
15	Optimisation of Biodiesel Production by Sunflower Oil Transesterification显示文摘	Antolin G Tinaut F V Briceno Y	2002	Bioresource Technology2002，83，2：	1
16	Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats显示文摘	Bethea J R Nagashima H Acosta M C Briceno C Gomez F Marcillo A E Loor K Green J Dietrich W D	1999	J Neurotrauma1999，16，10：	1
17	Capture of hair geometry from multiple images显示文摘	Paris S Briceno H M Sillion F X	2004	ACM Transactions on Graphics2004，23，3：	1
18	显示文摘	Briceno G	1995	Science1995，，：	1
19	Age related somatic mitochondrial DNA deletions in bone显示文摘	Papiha SS Rathod H Briceno I	1998	Clin Pathol1998，51，2：	1
20	As- sessment of eye bank-prepared posterior lamellar corneal tis- sue for endothelial keratoplasty 显示文摘	ROSE L BRICENO CA STARK W J GLORIA DG JUN AS	2008	Ophthalmology2008，115，2：	1

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