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| 1 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 2 | Arthroseopie assessment of the medial collateral ligament complex of the elbow 显示文摘 | Field LD Callaway GH O'Brien SJ | 1995 | Am Sports Med1995，4，： | 1 |
| 3 | Childhood hemolytic uremic syndrome,United Kingdom and Ireland显示文摘 | Lynn RM O′brien SJ Taylor CM | 2005 | Emerg Infect Dis2005，11，4： | 1 |
| 4 | Concurrent conditions and human Listeriosis,England, 1999-2009显示文摘 | Mook P O Brien SJ Gillespie IA | 2011 | Emerging Infectious Diseases2011，17，1： | 1 |
| 5 | 一般人群中发生心力衰竭的10年风险方程显示文摘目前急需能减轻心力衰竭负担的一级预防策略,但未见实用有效的风险预测工具。该研究旨在得出一个计算心力衰竭事件发生的10年风险方程。研究者根据7个社区队列,至少12年随访的个体水平数据,推导并验证了心力衰竭的种族和性别特异性10年风险方程。1985-2000年间招募年龄30~79岁在基线时无心血管病的研究对象,创建一个集合队列并随机分组以进行方程推导和内部验证。在另两个队列中也评估了该模型的性能。 | Khan SS Ning H Shah SJ Yancy CW Carnethon M Berry JD Mentz RJ O’Brien E Correa A Suthahar N de Boer RA Wilkins JT Lloyd-Jones DM 刘青 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 1 |
| 6 | The influence of hal genotype on AIDS 显示文摘 | Carrington M O' Brien SJ | 2003 | AnnuRev Med2003，54，： | 1 |
| 7 | Dynamic helical computed tomography scan accurately detects hemorrhage in patients with pelvic fracture显示文摘 | Pereira SJ O'Brien DP Luchette FA | 2000 | Surgery2000，128，6： | 1 |
| 8 | Breast cancer stem cells and their role in resistance to endocrine therapy显示文摘 | O'Brien CS Farnie G Howell SJ | 2011 | Horm Cancer2011，2，2： | 1 |
| 9 | Clinical characteristics and outcome in patients with psychogenic nonepileptic seizures 显示文摘 | Jones SG O' Brien TJ Adams SJ | 2010 | Psychosom Med2010，72，5： | 1 |
| 10 | Squamous cell carcinoma of the buccal mucosa: analysis of prognostic factors 显示文摘 | Urist MM O'Brien CJ Soong SJ | 1987 | Am J Surg1987，154，： | 1 |
| 11 | Anatomy,histology,and vascularity of the glenoid labrum显示文摘 | Arnozcky SP O'Brien SJ | 1992 | J Bone Joint Surg(Am)1992，74，： | 1 |
| 12 | Modeling of peptide adsorption interactions with a poly(lactic acid)surface显示文摘 | O'Brien CP Stuart SJ Bruce DA | 2008 | Langmuir2008，24，14： | 1 |
| 13 | Nature and origin of polymorphism in feline MHC class Ⅱ DRA and DRB genes显示文摘 | Yuhki N O'Brien SJ | 1997 | J Immunol1997，158，6： | 1 |
| 14 | The milking maneuver:a new test to evaluate the MCL of the elbow in the throwing athlete显示文摘 | Veltri DM O'Brien SJ Field LD | 2002 | Sports Med2002，5，： | 1 |
| 15 | Alpha4beta2 nicotinic recep-tot status in Alzheimer's disease using 1231-5IA-85380 single-photon-e- mission computed tomography 显示文摘 | O'Brien Jr Colloby SJ Pakrasi S | 2007 | J Neurol Neurosurg Psychiatry2007，78，4： | 1 |
| 16 | Relationship of orthostat- ic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression 显示文摘 | Calloby SJ Vasudev A O'Brien JT | 2011 | Br J Psychiatry2011，199，5： | 1 |
| 17 | Red blood cell transfusions and nosocomial infections in critically ill patients 显示文摘 | Taylor RW Or Brien J Trottier SJ | 2006 | Crit Care Med2006，34，： | 1 |
| 18 | The late Miocene radiation of modem Felidae:a genetic assessment显示文摘 | Johnson WE Eizirik E Pecon-Slattery J Murphy W J Antunes A Teeling E O'Brien SJ | | 0，，： | 1 |
| 19 | Advances in pediatric rhabdomyosarcoma characterization and disease model development显示文摘 | O' Brien D Jacob AG Qualman SJ | 2012 | Histol Histopathol2012，27，1： | 1 |
| 20 | Significant long term reduction in colorectal cancer mortality with colonoscopic polypectomy: findings of the National Polyp Study 显示文摘 | Zauber AG Winawer SJ O' Brien M J | 2007 | Gastroenterology2007，132，2： | 1 |
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