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| 1 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 2 | Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol显示文摘The majority of pregnancy loss in ruminants occurs during the first three weeks after conception, particularly during the period of conceptus elongation that occurs prior to pregnancy recognition and implantation. This review integrates established and new information on the biological role of ovarian progesterone(P4), prostaglandins(PGs),interferon tau(IFNT) and cortisol in endometrial function and conceptus elongation. Progesterone is secreted by the ovarian corpus luteum(CL) and is the unequivocal hormone of pregnancy. Prostaglandins(PGs) and cortisol are produced by both the epithelial cells of the endometrium and the trophectoderm of the elongating conceptus. In contrast, IFNT is produced solely by the conceptus trophectoderm and is the maternal recognition of pregnancy signal that inhibits production of luteolytic pulses of PGF2αby the endometrium to maintain the CL and thus production of P4. Available results in sheep support the idea that the individual, interactive, and coordinated actions of P4, PGs, IFNT and cortisol regulate conceptus elongation and implantation by controlling expression of genes in the endometrium and/or trophectoderm. An increased knowledge of conceptus-endometrial interactions during early pregnancy in ruminants is necessary to understand and elucidate the causes of infertility and recurrent early pregnancy loss and provide new strategies to improve fertility and thus reproductive efficiency. | Kelsey Brooks Greg Burns Thomas E Spencer | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 4 |
| 3 | The taxonomic value of floral characters in tribe Trigonelleae (Leguminosae),with special reference to Medicago显示文摘 | Small E Crompton C W Brookes B S | 1981 | Canadian Journal of Botany1981，59，9： | 1 |
| 4 | The Effete of Temperature on the Hardness Of Polycrystalline Cubic Boron Nitride Cut ting Tool Materials显示文摘 | Harris T K Brookes E J Taylor C J | 2004 | International Journal of Refractor Metal and Hard Materials2004，22，2： | 1 |
| 5 | An extraction method for measuring soil microbial biomass C显示文摘 | Vance E D Brooks P C Jenkinson D S | 1987 | Soil Biology and Biochemistry1987，19，6： | 1 |
| 6 | Molecular cloning of the cDNA for androgen-dependent sperm-coating glycoproteins secreted by the rat epididymis显示文摘 | BROOKS D E MEANS A R WRIGHT E J | 1986 | Eur J Biochem1986，161，： | 1 |
| 7 | Factors associated with early presentation of acute stroke显示文摘 | Feldmann E Gordon N Brooks JM | 1993 | Stroke1993，24，12： | 1 |
| 8 | Elastin is an essential determinant of arterial morphogenesis显示文摘 | D Y Li B Brooke E C Davis | 1998 | Nature1998，393，21： | 1 |
| 9 | An extraction method for measuring soil microbial biomass显示文摘 | Vance E D Brookes P C Jenkinson D S | 1987 | Soil Biology & Biochemistry1987，19，： | 1 |
| 10 | An extraction meth-od for measuring soil microbial biomass C显示文摘 | Vance E D Brookes P C jenkinson D S | 1987 | Soil Biology^Biochemistry1987，19，6： | 1 |
| 11 | Injury to muscle fibres after single stretches of passive and maximally stimulated muscles in mice 显示文摘 | Brooks SV Zerba E Faulkner JA | 1995 | J Physiol1995，488，2： | 1 |
| 12 | An Extraction Method for Measuring Soil Microbial Biomass C 显示文摘 | Vance E D Brookes P C Jenkinson D S | 1987 | Soil Biol- ogy and Biochemistry1987，19，6： | 1 |
| 13 | Biomass torrefaction studies with a molecular beam mass spectrometer显示文摘 | NIMLOS M N BROOKING E LOOKER M | 2003 | American Chemical Society Division of Petroleum Chemistry2003，48，2： | 1 |
| 14 | Site-specific insertion of genes into integrons: role of the 59-base element and determination of the recombination cross over point 显示文摘 | Hall R M Brookes D E Stokes H W | 1991 | Journal of Molecular Microbiology and Biotechnology1991，5，8： | 1 |
| 15 | T-box genes in human disorders显示文摘 | Packham E A Brook J D | 2003 | Hum Mol Genet2003，12，1： | 1 |
| 16 | An extraction method for measuring soil microbial biomass C显示文摘 | VANCE E D BROOKES P C JENKISON D C | 1987 | Soil Biol Biochern1987，19，： | 1 |
| 17 | Methodology for predicting European short-haul air transport demand from regional airports显示文摘 | Brooke A S Caves R E Pitfield D E | 1994 | Journal of Air Transport Management1994，1，1： | 1 |
| 18 | Long-term outcomes after gastric bypass显示文摘 | White S Brooks E Jurikova L | 2005 | Obes Surg2005，15，2： | 1 |
| 19 | Foreign powers buy influence at think tanks 显示文摘 | LIPTON E BROOKE W CONFESSORE N | 2014 | The New York Times2014，，12： | 1 |
| 20 | Dual-energy subtraction chest radiography: what to look for beyond calcified nodules 显示文摘 | Kuhlman J E Collins J Brooks G N | 2006 | Radiographys2006，26，1： | 1 |
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