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| 1 | A 1000-year chironomid-based salinity reconstruction from varved sediments of Sugan Lake,Qaidam Basin,arid Northwest China,and its palaeoclimatic significance显示文摘A 1000-year high-resolution(~10 years) chironomid record from varved sediments of Sugan Lake,Qaidam Basin on the northern Tibetan Plateau,is presented.The chironomid assemblages are mainly composed of the relatively high-saline-water taxa Psectrocladius barbimanus-type and Orthocladius/Cricotopus,and the relatively low-saline-water taxa Procladius and Psectrocladius sordidellus-type.Variations in the chironomid fauna and inferred salinities suggest that over the last millennium,the Sugan Lake catchment has alternated between contrasting climatic conditions,having a dry climate during the period 990―1550 AD,a relatively humid climate during the Little Ice Age(LIA)(1550―1840 AD),and a dry climate again from 1840 AD onwards.At the decadal to centennial scale,a wet event around 1200―1230 AD,interrupting the generally arid period(990―1550 AD),and a dry event around 1590―1700 AD,punctuating the generally humid period(1550―1840 AD),are clearly documented.Trends in the chironomid-based salinity time series indicate a highly unstable climate during the LIA when salinity fluctuations were of greater magnitude and higher frequency.The effective moisture evolution in the Sugan Lake catchment during the last millennium reconstructed by chironomid analysis is in broad agreement with previous palaeo-moisture data derived from other sites in arid Northwest China(ANC).The LIA,characterized by generally humid conditions over the west-erly-dominated ANC was distinctly different from that in monsoonal China,implying an 'out-of-phase' relationship between moisture evolution in these two regions during the past 1000 years. | CHEN JianHui CHEN FaHu ZHANG EnLou BROOKS Stephen J ZHOU AiFeng ZHANG JiaWu | 2009 | Chinese Science Bulletin2009，54，20： | 20 |
| 2 | 柴达木盆地苏干湖年纹层岩芯摇蚊记录的过去1000年干旱区湿度变化及其意义显示文摘利用柴达木盆地苏干湖具有年纹层的沉积岩芯,以摇蚊亚化石分析恢复了研究区近千年来10年分辨率的湿度演变历史.研究表明,苏干湖岩芯中的摇蚊亚化石主要由高咸水属种Psectrocladius barbimanus-type和Orthocladius/Cricotopus与低咸水属种Procladius和Psectrocladius sordidellus-type组成,依据其相对丰度的变化,结合摇蚊-盐度转换函数重建的盐度波动,区域过去1000年湿度变化可划分为3个阶段:990~1550AD为气候整体干旱期、1550~1840AD为气候整体湿润期、1840~2000AD为全球变暖下的气候再次干旱期.高分辨率的记录还发现,在年代际到百年尺度上,存在1200~1230AD干旱背景下的湿润阶段和1590~1700AD湿润小冰期内部的干旱阶段;就气候变率而言,湿润小冰期时段摇蚊种群组合及重建的盐度变化幅度增大,频率加快,指示出小冰期气候的不稳定性特征.该记录得到西风环流影响区的其他古湿度资料支持.苏干湖高分辨率摇蚊记录的湿润小冰期气候与中国东部季风区降水变化存在明显的差异,表明中国内陆干旱区和东部季风区湿度变化即使在近1000年来也存在相位差. | 陈建徽 陈发虎 张恩楼 Stephen J Brooks 周爱锋 张家武 | 2009 | 科学通报2009，54，20： | 13 |
| 3 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 4 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 5 | Malnutrition in cirrhosis:More food for thought显示文摘Malnutrition is highly prevalent in liver cirrhosis and its presence carries important prognostic implications.The clinical conditions and pathophysiological mechanisms that cause malnutrition in cirrhosis are multiple and interrelated.Anorexia and liver decompensation symptoms lead to poor dietary intake;metabolic changes characterised by elevated energy expenditure,reduced glycogen storage,an accelerated starvation response and protein catabolism result in muscle and fat wasting;and,malabsorption renders the cirrhotic patient unable to fully absorb or utilise food that has been consumed.Malnutrition is therefore a considerable challenge to manage effectively,particularly as liver disease progresses.A high energy,high protein diet is recognised as standard of care,yet patients struggle to follow this recommendation and there is limited evidence to guide malnutrition interventions in cirrhosis and liver transplantation.In this review,we seek to detail the factors which contribute to poor nutritional status in liver disease,and highlight complexities far greater than“poor appetite”or“reduced oral intake”leading to malnutrition.We also discuss management strategies to optimise nutritional status in this patient group,which target the inter-related mechanisms unique to advanced liver disease.Finally,future research requirements are suggested,to develop effective treatments for one of the most common and debilitating complications afflicting cirrhotic patients. | Brooke Chapman Marie Sinclair Paul J Gow Adam G Testro | 2020 | World Journal of Hepatology2020，12，11： | 8 |
| 6 | Environmental controls on the perology of a late Holocene speleothem from Botswana with annual layers of aragonite and calcite显示文摘 | Railsback L Brook G Chen J | 1994 | Journal of Sedimentary Research1994，64，： | 2 |
| 7 | Is iron overload in alcohol-related cirrhosis mediated by hepcidin?显示文摘In this case report we describe the relationship between ferritin levels and hepcidin in a patient with alcohol-related spur cell anemia who underwent liver transplantation.We demonstrate a reciprocal relation-ship between serum or urinary hepcidin and serum ferritin,which indicates that inadequate hepcidin production by the diseased liver is associated with elevated serum ferritin.The ferritin level falls with increasing hepcidin production after transplantation.Neither inflammatory indices(IL6)nor erythropoietin appear to be related to hepcidin expression in this case.We suggest that inappropriately low hepcidin production by the cirrhotic liver may contribute substantially to elevated tissue iron stores in cirrhosis and speculate that hepcidin replacement in these patients may be of therapeutic benefi t in the future. | Tariq Iqbal Azzam Diab Douglas G Ward Matthew J Brookes Chris Tselepis Jim Murray Elwyn Elias | 2009 | World Journal of Gastroenterology2009，15，46： | 2 |
| 8 | p38 mitogen-actiated protein kinase regulates cycloxxygenase - 2 mRNA stability and transcription in ipopolysacharide-treated human monocytes显示文摘 | Dean J L Brook M Clark A R | 1999 | J Biol Chen1999，274，： | 1 |
| 9 | Free radical and tissue damage produced by exercise显示文摘 | DAVIES K J A QUINTANILHA T A BROOKS G A | 1982 | Biochem Biopsy Res Commun1982，107，4： | 1 |
| 10 | Synchronous liver resection and cryotherapy for colorectal metastases : survival analysis 显示文摘 | Brooks A J Wang F Alfredson M d al | 2005 | Surgeon2005，3，4： | 1 |
| 11 | National beef tenderness survey-1998显示文摘 | Brooks J C Gwartney J B Hale D S | 2000 | J Anim Sci2000，78，： | 1 |
| 12 | Design and synthese of 2-methyl-2-{4-phenoxy}propionic acids:a new class of dual PPARα/γagonists显示文摘 | Etgen G J Rito C J | 2001 | J Med Chem2001，44，13： | 1 |
| 13 | Thoughts beyond words:When language overshadows insight显示文摘 | Ohlsson S Brook K | 1993 | Journal of Experimental Psychology:General1993，，： | 1 |
| 14 | TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA显示文摘 | CHOCKALINGAM A BROOKS J C CAMERON J L | 2009 | Immunol Cell Biol2009，87，3： | 1 |
| 15 | Effects of day/night temperature differential and irradiance on the flower stem quality of Sandersonia aorantiaca显示文摘 | Davies L J Brooking I R Catley J L | 2002 | Scientia Horticulturae2002，，95： | 1 |
| 16 | Detection of nickeliferous rocks by alysus of herbarium species of indicator plants显示文摘 | Brooks R R Lee J Reeves R D | 1977 | Joumal of Geochemical Exploration1977，，5： | 1 |
| 17 | Environmental jolts and industry revolutions: Organizational responses to discontinuous change显示文摘 | Meyer A D Brook G Goes J B | 1990 | Strategic Management Journal1990，11，： | 1 |
| 18 | Role of brain prostaglandins in the control of vasopressin secretion in the conscious rat 显示文摘 | Brooks Share Crofton J T | 1986 | Endocrinology1986，118，4： | 1 |
| 19 | The Effete of Temperature on the Hardness Of Polycrystalline Cubic Boron Nitride Cut ting Tool Materials显示文摘 | Harris T K Brookes E J Taylor C J | 2004 | International Journal of Refractor Metal and Hard Materials2004，22，2： | 1 |
| 20 | The essence of SNPs显示文摘 | Brookes A J | 1999 | Gene1999，234，2： | 1 |
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