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| 1 | Evaluation of intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis显示文摘BACKGROUND The main endemic areas of alveolar echinococcosis(AE)are in Central Europe and Western China.Both the infiltration of intrahepatic vascular and bile duct structures as well as extrahepatic disease can lead to further complications and may increase morbidity in patients with AE.AIM To evaluate vascular/biliary involvement in hepatic AE and its distant extrahepatic disease manifestations in an international collective was the aim.METHODS Consecutively,five experienced examiners evaluated contrast-enhanced abdominal computed tomography(CT)scans for 200 patients with hepatic AE of each of four locations(n=50)in Germany,France and China.Therefore,we retrospectively included the 50 most recent abdominal contrast-enhanced CT examinations at each center,performed because of hepatic AE from September 21,2007 to March 21,2018.AE liver lesions were classified according to the echinococcosis multilocularis Ulm classification for CT(EMUC-CT).Distant extrahepatic manifestations were documented either by whole body positron emission tomography–CT or with the addition of thoracic CT and cranial magnetic resonance imaging.Vascular/biliary involvement of the hepatic disease as well as the presence of distant extrahepatic manifestations were correlated with the EMUC-CT types of liver lesion.Statistical analysis was performed using SAS Version 9.4(SAS Institute Inc.,Cary,NC,United States).RESULTS Distant extrahepatic AE manifestations were significantly more frequent in China than in Europe(P=0.0091).A significant relationship was found between the presence of distant extrahepatic disease and AE liver lesion size(P=0.0075).Vascular/biliary structures were involved by the liver lesions significantly more frequently in China than in Europe(P<0.0001),and vascular/biliary involvement depended on lesion size.Different morphological types of AE liver lesions led to varying frequencies of vascular/biliary involvement and were associated with different frequencies of distant extrahepatic manifestations:Vascular/biliary involvement as a function of lesions primary morphology ranged from 5.88%of type IV liver lesions to 100%among type III lesions.Type IV differed significantly in these associations from types I,II,and III(P<0.0001).With respect to extrahepatic disease,the primary morphology types IV and V of liver lesions were not associated with any case of distant extrahepatic disease.In contrast,distant extrahepatic manifestations in types I–III were found to varying degrees,with a maximum of 22%for type III.CONCLUSION Different CT morphological patterns of hepatic AE lesions influence vascular/biliary involvement and the occurrence of distant extrahepatic manifestations.There are intercontinental differences regarding the characteristics of AE manifestation. | Tilmann Graeter Hai-Hua Bao Rong Shi Wen-Ya Liu Wei-Xia Li Yi Jiang Julian Schmidberger Eleonore Brumpt Eric Delabrousse Wolfgang Kratzer | 2020 | World Journal of Gastroenterology2020，26，29： | 7 |
| 2 | Miniincision anterior approach does not increase dislocation rate:a study of 1037 total hip replacements显示文摘 | Siguier T Siguier M Brumpt B | 2004 | Clin Orthop Relat Res2004，，426： | 1 |
| 3 | Mini-incision anterior approach does not increase dislocation rate:a study of 1 037 total hip replacements显示文摘 | Siguier T Siguier M Brumpt B | 2004 | Clin Orthop Relat Res2004，，426： | 1 |
| 4 | Mini - incision anterior ap- proach does increase dislocation rate:a study of 1037 total hip replacements 显示文摘 | Siguier T Siguier M Brumpt B | 2004 | Clin Orthop Relat Res2004，，426： | 1 |
| 5 | Mini - incision anterior ap- proach does not increase dislocation rate:a study of 1037 total hip replacements 显示文摘 | Siguier T Siguier M Brumpt B | 2004 | Clin Orthop Relat Res2004，，426： | 1 |
| 6 | Influence of rifampin on the pharmacokinetics of pefloxacin显示文摘 | Humbert G Brumpt I Montay G | 1991 | Clin Pharmacol Ther1991，50，6： | 1 |
| 7 | The sparfloxacin safety group overview of electrocardiographic and cardiovasculae safety data for sparfloxacin 显示文摘 | Jaillon P Mrganorth J Brumpt I | 1996 | J Antmicrob Chemother1996，37，： | 1 |
| 8 | Mini - incision anterior ap- proach does not increase dislocation rate : a study of 1037 to- tal hip replacements 显示文摘 | Siguier T Siguier M Brumpt B | 2004 | Clin Orthop Relat Res2004，，426： | 1 |
| 9 | Mini-incision anterior approach does not increase dislocation rate: a study of 1037total hip replacements显示文摘 | Siguier T Siguier M Brumpt B | 2004 | Clin Orthop Relat Res2004，426，： | 1 |
| 10 | Mini-incision anterior approach does not increase dislocation rate : a study of 1037 total hip replacements 显示文摘 | Siguier T Siguier M Brumpt B | 2004 | Clin Orthop Relat Res2004，426，： | 1 |
| 11 | Retinoic acid resistance in NB4 APL cells is associated with lack of interferon alpha synthesis Statl and p48 induction显示文摘 | Pelicano L Brumpt C Pitha P M | 1999 | Oncogene1999，18，27： | 1 |
| 12 | Mini-incision anterior approach does not increase dislocation rate: a study of 1037 total hip replacements显示文摘 | Siguier T Siguier M Brumpt B | 2004 | Clin Orthop Relat Res2004，426，： | 1 |
| 13 | Mini - incision anterior ap-proach does increase dislocation rate:a study of 1037 total hip replacements 显示文摘 | Siguier T Siguier M Brumpt B | 2004 | Clin Orthop Relat Res2004，，426： | 1 |
| 14 | Mini-incision anterior approach does not increase dislocation rate:a study of 1037 total hip replacements显示文摘 | Siguier T Siguier M Brumpt B | 2004 | Clin Orthop Relat Res2004，，426： | 1 |
| 15 | Retinoic acid resistance in NB4 APL cells is associated with lack of interferon alpha synthesis Statl and p48 induction 显示文摘 | Pelicano L Brumpt C Pitha PM | 2010 | Oncogene2010，18，1： | 1 |
| 16 | Mini-incision anterior approach does not increase dislocation rate:a study of 1037 total hip replacements显示文摘 | Siguier M Brumpt B | 2004 | Clin Orthop Relat Res2004，426，： | 1 |
| 17 | Retinoic acid resistance in NB4 APL cells is associated with lack of interferon alpha synthesis Statl and p48 induction 显示文摘 | Pelicano L Brumpt C Pitha P M | 1999 | Oncogene1999，18，： | 1 |
| 18 | Mini-incision anterior approach dose not increase dislocation rate:a study of 1 037 total hip replacements 显示文摘 | Siguier T Siguier M Brumpt B | 2004 | Clin Orthop2004，1，426： | 1 |
| 19 | Mini-incision anterior approachdoes not increase dislocation rate: a study of 1 037 total hipreplacements显示文摘 | Siguier T Siguier M Brumpt B | 2004 | Clin Orthop Relat Res2004，426，： | 1 |
| 20 | Mini - incision anterior approach dose not increase dislocation rate: a study of 1037 total hip replace- ments 显示文摘 | Siguier T SiguierM Brumpt B | 2004 | Clin Orthop2004，426，： | 1 |
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