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| 1 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 2 | Translation-invariant de-noising using multiwavelets显示文摘 | BUI T D CHEN G Y | 1998 | IEEE Transaction on Signal Processing1998，46，12： | 1 |
| 3 | Inter-ocular and inter-session reliability of the electroretinogram photopic negative response (PhNR) in nonhuman primates显示文摘 | Fortune B Bui BV Cull G | 2004 | Exp Eye Res2004，78，1： | 1 |
| 4 | Propagation of transients in dispersive dielectric media显示文摘 | Stuchly S S Costache G I | 1991 | IEEE Trans MTT1991，39，7： | 1 |
| 5 | Windows version of the ion trap simulation program ITSIM: A powerful heuristic and predictive tool in ion trap mass spectrometry显示文摘 | BUI H A COOKS R G | 1998 | Journal of Mass Spectrometry1998，33，4： | 1 |
| 6 | Rotation invariant pattern recognition using ridgelet, wavelet cycle-spinning, and fourier features 显示文摘 | Chen G Y Bui T D Krzyzak A | 2005 | Pattern Recognition2005，38，12： | 1 |
| 7 | Translation-invariant denoising using multiwavelets 显示文摘 | Bui T D Chen G | 1998 | IEEE Trans SP1998，46，12： | 1 |
| 8 | Image denoising with neighbour dependency and customized wavelet and threshold显示文摘 | CHEN G Y BUI T D KRZYAK A | 2005 | Pattern Recognition2005，38，1： | 1 |
| 9 | Epidemiology and risk profile of heart failure显示文摘 | Bui AL Horwich TB Fonarow G C | 2011 | Nat Rev Cardio2011，8，1： | 1 |
| 10 | Comparison of environmental and genetic factors for Parkinson's disease between Chinese and Caucasians显示文摘 | CHAN D K CORDATO D BUI T MELLICK G WOO J | 2004 | Neuroepidemiology2004，23，12： | 1 |
| 11 | Multiwavelet Denoising Using Neighboring Coefficients显示文摘 | Chen G Y Bui T D | 2003 | IEEE Signal Processing Letters2003，10，7： | 1 |
| 12 | Effect of PEEP ventilation on re- nal function, plasma renin, aldosterone, neurophysins and urinary ADH, and prostaglandins显示文摘 | Annat G Viale JP Bui Xuan B | 1983 | Anesthesiology1983，58，2： | 1 |
| 13 | Systemic and translesional of coagulation,fibrinolytic,and inhibitory,systems in candidates for coronary angioplasty:basal state and effect of successful dilation显示文摘 | Emma G Bui DT | 1999 | Am Heart J1999，137，： | 1 |
| 14 | Image de-noising with neighboring dependency and customized wavelet and threshold显示文摘 | CHEN G Y BUI T D KRZYZAK A | 2005 | Pattern Recognition2005，38，1： | 1 |
| 15 | SYNAPSE+ + : code dissemina- tion in wireless sensor networks using fountain codes 显示文摘 | Rossi M Bui N Zanca G | 2010 | IEEETransactions on Mobile Computing2010，9，12： | 1 |
| 16 | Angiolipomas of the central nervous system显示文摘 | Andalus N Balko G Bui H | 2000 | J Neurooncol2000，49，3： | 1 |
| 17 | Invariant Fourier-wavelet Descriptor for Pattern Recognition显示文摘 | Chen G Y Bui T D | 1999 | Pattern Recognition1999，32，7： | 1 |
| 18 | Image denoising using neighboring wavelet coefficients显示文摘 | Chen G Y Bui T D Krzyzak A | 2005 | lntegrated Computer- Aided Engineering2005，12，1： | 1 |
| 19 | 查看详情显示文摘 | S Ramtani G Dirras H Q Bui | | 0，，： | 1 |
| 20 | Translation invariant de-noising using multi-wavelets显示文摘 | Bui T D Chen G | | 0，，12： | 1 |
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