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| 1 | Sleep disorders and chronic kidney disease显示文摘Sleep disorders have a profound and well-documented impact on overall health and quality of life in the general population. In patients with chronic disease, sleep disorders are more prevalent, with an additional morbidity and mortality burden. The complex and dynamic relationship between sleep disorders and chronic kidney disease(CKD) remain relatively little investigated. This article presents an overview of sleep disorders in patients with CKD, with emphasis on relevant pathophysiologic underpinnings and clinical presentations. Evidence-based interventions will be discussed, in the context of individual sleep disorders, namely sleep apnea, insomnia, restless leg syndrome and excessive daytime sleepiness. Limitations of the current knowledge as well as future research directions will be highlighted, with a final discussion of different conceptual frameworks of the relationship between sleep disorders and CKD. | Stephanie C Maung Ammar El Sara Cherylle Chapman Danielle Cohen Daniel Cukor | 2016 | World Journal of Nephrology2016，5，3： | 13 |
| 2 | Chronic overexpression of PNPLA3^sup I148M^ in mouse liver causes hepatic steatosis显示文摘 | Li John Zhong Huang Yongcheng Karaman Ruchan Ivanova Pavlina T Brown H Alex Roddy Thomas Castro-Perez Jose Cohen Jonathan C Hobbs Helen H | 2012 | EN2012，，11： | 3 |
| 3 | 使用体外重建皮肤模型研究真皮成纤维细胞对皮肤色素沉着的重要调节作用:皮肤光老化的影响显示文摘已有大量研究强调了人类角质形成细胞在皮肤色素沉着中所起的作用。例如,角质形成细胞通过释放大量的促色素沉着旁分泌生长因子,如αMSH、内皮素1(ET-1)、干细胞因子(SCF)和多种细胞因子,参与紫外线(UV)急性照射诱导的黑素合成(晒黑)。然而,越来越多的证据显示,真皮内成分在皮肤色素沉着调控中的作用不容忽视。20世纪90年代中期,证实细胞外基质(ECM)可调节黑素细胞的增殖、凋亡抑制和黑素生成活性。有报道证实,真皮成纤维细胞可通过分泌可溶性因子对色素沉着起调控作用。另外,对于构成性肤色,研究发现在掌跖,由成纤维细胞产生的Dikkopf-1(DKK-1)对黑素细胞的生长、活性以及对黑素小体转移均有抑制作用,且认为是这两处身体部位颜色较浅的原因。反之,深肤色皮肤内成纤维细胞分泌的神经调节蛋白1(NGR-1)的促色素沉着效应提示,该特定信号分子在决定高度色素沉着的皮肤类型中发挥作用。此外,在各种先天性色素沉着过度障碍中,如系统性硬皮病、皮肤纤维瘤、多发性神经纤维瘤的咖啡牛奶斑和泛发性进行性色素异常症,已知真皮黑素生成生长因子数量增加;这些因子包括SCF、肝细胞生长因子(HGF)或角质形成细胞生长因子(KGF)。表皮与细胞间质之间紧密的互动也可能在黑素细胞内稳态中发挥作用。最近已证实,层粘连蛋白332可通过调节L酪氨酸摄取来促进黑素生成。生长因子/细胞因子调节环也存在于真皮细胞和表皮细胞之间,并参与色素沉着的调控。 | 陈旭 孔佩慧 Duval C Cohen C Chagnoleau C | 2016 | 中华皮肤科杂志2016，49，10： | 2 |
| 4 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 5 | Definition of epitopes for monoclonal antibodies developed against purified sodium channel protein: implications for channel structure 显示文摘 | Kolibal SS Brady C Cohen SA | 1998 | J Membr Biol1998，165，1： | 1 |
| 6 | Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25 (high) T cells in human STAT5b deficiency显示文摘 | Cohen A C Nadeau K C Tu W | 2006 | J Immunol2006，177，5： | 1 |
| 7 | Cardiac tamponade in the 'new device' era:evaluation of 6999 consecutive percutaneous coronary interventions显示文摘 | Kopistansky C Cohen M | 2000 | Am Heart J2000，140，2： | 1 |
| 8 | Treatment of Churg-Strauss syndrome without poor prognosis factors: a muhicenter, prospective, randomized, open label study of seventy-two patients显示文摘 | Ribi C Cohen P Pagnoux C Mahr A Arene J P Lauque D | 2008 | Arthritis Rheum2008，58，： | 1 |
| 9 | Postcesarean fever and uterine rupture in a subsequent trial of labor显示文摘 | Shipp T Zelop C Cohen AP | 2001 | Am J Obstet Gynecol2001，184，2： | 1 |
| 10 | Frontal lobe epielpsy:diagnosis and surgical treatment 显示文摘 | Wetin NM Cohen GA Maher C | 2002 | Neurosurg Rev2002，25，3： | 1 |
| 11 | Postseismic dformation due to subcrustal viscoelastic relaxation following dip-slip earthquakes显示文摘 | Cohen S C | 1984 | J Geophys Res1984，89，： | 1 |
| 12 | Should you cancel the operation when a child has an upper respiratory tract infection?显示文摘 | COHEN M M CAMERON C B | 1991 | Anesth Analg1991，72，： | 1 |
| 13 | Verbs and Adverbs:Multidimensional Motion Interpolation 显示文摘 | Rose C E Cohen M Bodenheimer B | 1998 | IEEE Computer Graphics & Application (S0272-1716)1998，18，5： | 1 |
| 14 | Product Inhibi tion in the Acid Forming Stage of the Anaerobic Digestion Process显示文摘 | Zoetemeyer R J Matthljsen A J C M Cohen A | 1982 | Water Research1982，16，5： | 1 |
| 15 | Remifentanil-midazolam compared to sufentanil-rnidazolam for ICU long-term sedation显示文摘 | Baillard C Cohen Y Le Toumelin P | 2005 | Ann Fr Anesth Reanim2005，24，5： | 1 |
| 16 | Accumulation of arachidonic acid-rich triacylglycerols in the microalga Parietochloris incisa ( Trebuxiophyceae, ehlorophyta) 显示文摘 | Bigogno C Khozin G I Cohen Z | 2002 | Phytochemistry2002，60，： | 1 |
| 17 | Differential mechanisms of microparticle transfer to B cells and monocytes: anti-inflamma- tory properties of micropartieles显示文摘 | Koppler B Cohen C Schlondorff D | 2006 | Eur J Immunol2006，36，3： | 1 |
| 18 | Role of decidua in tropho- blastic invasion 显示文摘 | Cohen M Wuillemin C lrion O | 2010 | Neuroendocrinology Letters2010，31，2： | 1 |
| 19 | Airport infrastructure spillovers in a network system显示文摘 | Cohen J P Morrison Paul C J | 2003 | Journal of Urban Economics2003，54，3： | 1 |
| 20 | N-butyl 2-cyanoacrylate(n-BCA)embolization of a cerebellar hemangioblastoma 显示文摘 | Munyon C Chowdhry SA Cohen ML | 2011 | J Neurointerv Surg2011，3，4： | 1 |
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