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| 1 | 乙型肝炎病毒导致的肝硬化伴肝癌患者血清中N糖组学改变显示文摘肝细胞癌(HCC)是最常见的肿瘤和最主要的死因之一,多发生于HBV和HCV感染导致的肝硬化患者,筛查肝硬化人群,早期诊断HCC可降低肿瘤的病死率。甲胎蛋白(AFP)是目前广泛应用的辅助诊断HCC的血清学指标,是对B超、CT等影像学诊断的有效补充。最近的荟萃分析表明,不同研究论文报道的AFP的灵敏度和特异度有很大的不同,这种现象不能完全用AFP的临界值不同解释。血清中的N糖蛋白主要由肝脏和B淋巴细胞合成,N糖成分的改变可反应肝脏或B淋巴细胞功能的改变,糖链的改变常常反应出机体的异常改变。糖组学在诊断领域的应用曾经因为缺少合适的分析技术而受限制,血清中N糖组学分析技术克服了这一屏障。本研究的目的是评价血清中N糖指纹图谱应用于乙型肝炎后肝硬化伴肝癌辅助诊断的意义。 | 刘学恩 Liesbeth Desmyter 高春芳 Wouter Laroy Sylviane Dewaele Valerie Vanhooren 王玲 庄辉 Nico Callewaert Claude Libert Roland Contreras 陈翠英 | 2008 | 中华肝脏病杂志2008，16，1： | 11 |
| 2 | Electrophretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system 显示文摘 | Laterre EC Callewaert A Hereans JF | 1970 | Neurology1970，20，： | 1 |
| 3 | An enzyme-release assay for natural cytotoxicity显示文摘 | Korzeniewski C Callewaert DM | 1983 | J Immunol Methods1983，64，： | 1 |
| 4 | An enzyme-release assay for natural cytotoxicity显示文摘 | Korzeniewski C Callewaert D M | 1983 | J Immunol Methods1983，64，3： | 1 |
| 5 | Metal solubility as a function of pH in a contaminated dredged sediment affected by Oxidation显示文摘 | Tack F M Callewaert O W J J Verloo M G | 1996 | Environmental Pollution1996，91，2： | 1 |
| 6 | Radical prostatectomy can provide a cure for well-selected clinical stage T3 prostate cancer显示文摘 | Van Poppel H Goethuys H Callewaert P | 2000 | Eur Urol2000，38，4： | 1 |
| 7 | Overview of resistance to systemic therapy in patients with breast cancer显示文摘 | Callewaert PR Van Poppel H Vanderschueren D | | 0，，9： | 1 |
| 8 | The Rcs two- component system regulates espression of lysozyme inhi- tors and is induced by exposure to lysozyme显示文摘 | Callewaert L Vanoirbeek KG Luriquin I | 2009 | J Bacteriol2009，191，6： | 1 |
| 9 | Use of HDEL-tagged Trichoderma reesei mannosyl oligosaccharide1,2-alpha-mannosidase for N-glycan engineering in Pichia pastoris显示文摘 | Callewaert N Laroy W Cadirgi H | | 0，，： | 1 |
| 10 | Sex steroids during bone growth:a comparative study between mouse models for hypogonadal and senile osteoporosis显示文摘 | Ophoff J Venken K Callewaert F | | 0，，10： | 1 |
| 11 | An enzyme-release assay for natural cytotoxicity显示文摘 | Korzeniewski C Callewaert DM | 1983 | Immunol Methods1983，64，： | 1 |
| 12 | Potassium currents in cardiac cells显示文摘 | Carmeliet E Biermans G Callewaert GV | 1987 | Experiential1987，43，1112： | 1 |
| 13 | Role of the lyso- zyme inhibitor Ivy in growth or survival ofEscherichia coli and Pseudomonas aeruginosa bacteria in hen egg white and in human saliva and breast milk显示文摘 | Deckers D Vanlint D Callewaert L | 2008 | Appl Environ Microbi- ol2008，74，14： | 1 |
| 14 | Scrotal approach to both palpable and impalpable undescended testes:should it become our first choice显示文摘 | Callewaert PRH Rahnama'i MS Biallosterski BT | | 0，，： | 1 |
| 15 | Lysozymes in the animal kingdom显示文摘 | CALLEWAERT L MICHIELS CW | 2010 | Journal of Biosciences2010，35，1： | 1 |
| 16 | Serum albumin- alginate coated microspheres: role of the inner gel in binding and release of the KRFK peptide 显示文摘 | Callewaert M Millot J M Lesage J | 2009 | lnt JPharm2009，366，12： | 1 |
| 17 | Quantitative chemiluminescent immunoassay for NF-kappaB-DNA binding activity显示文摘 | Gupta SV Mcgowen RM Callewaert DM | 2005 | J Immunoassay Immunochem2005，26，2： | 1 |
| 18 | Purification and characterization of a bacteriocin produced by Lactobacillus acidophilus IBB801显示文摘 | ZAMFIR M CALLEWAERT R CORNEA P C | 1999 | Journal of Applied Microbiology1999，87，： | 1 |
| 19 | Skeletalsexual dimorphism:relative contribution of sex steroids,GH-IGF1,and mechanical loading显示文摘 | CALLEWAERT F SINNESAEL M GIELEN E | 2010 | J Endocrinol2010，207，2： | 1 |
| 20 | Electrophretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system显示文摘 | Laterre EC Callewaert A Hereans JF | 1970 | Neurology1970，20，： | 1 |
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