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| 1 | Upregulation of the APE1 and H2AX genes and miRNAs involved in DNA damage response and repair in gastric cancer显示文摘Gastric cancer remains one of the leading causes of cancer-related death worldwide,and most of the cases are associated with Helicobacter pylori infection.This bacterium promotes the production of reactive oxygen species(ROS),which cause DNA damage in gastric epithelial cells.In this study,we evaluated the expression of important genes involved in the recognition of DNA damage(ATM,ATR,and H2AX)and ROS-induced damage repair(APE1)and the expression of some miRNAs(miR-15a,miR-21,miR-24,miR-421 and miR-605)that target genes involved in the DNA damage response(DDR)in 31 fresh tissues of gastric cancer.Cytoscape v3.1.1 was used to construct the postulated miRNA:mRNA interaction network.Analysis performed by real-time quantitative PCR exhibited significantly increased levels of the APE1(RQ=2.55,p<0.0001)and H2AX(RQ=2.88,p=0.0002)genes beyond the miR-421 and miR-605 in the gastric cancer samples.In addition,significantly elevated levels of miR-21,miR-24 and miR-421 were observed in diffuse-type gastric cancer.Correlation analysis reinforced some of the gene:gene(ATM/ATR/H2AX)and miRNA:mRNA relationships obtained also with the interaction network.Thus,our findings show that tumor cells from gastric cancer presents deregulation of genes and miRNAs that participate in the recognition and repair of DNA damage,which could confer an advantage to cell survival and proliferation in the tumor microenvironment. | Fernanda S.Manoel-Caetano Ana Flávia T.Rossi Gabriela Calvet de Morais Fábio Eduardo Severino Ana Elizabete Silva | 2019 | Genes & Diseases2019，6，2： | 5 |
| 2 | Effect of sucralfate on gastric intramucosal pH in critically ill patients显示文摘 | Calvet X Baigorri F Duarte M | 1997 | Intensive Care Med1997，23，7： | 1 |
| 3 | Characterization ofgas emissions from a Mediterranean broiler farm 显示文摘 | CalvetS Cambra-L6pez M Estelles F | 2011 | PoultryScience2011，90，3： | 1 |
| 4 | Contribution of SiO_(2》 in neutron-induced SEU in SRAMs显示文摘 | WROBEL F PALAU J M CALVET M C | 2003 | IEEE Trans Nucl Sci2003，50，6： | 1 |
| 5 | Hurd Peninsula glaciers, Livingston, Island, Antarctica, as indicators of regional warming: Ice-volume changes during the period 1956 -2000 显示文摘 | Molina C Navarro F J Calvet J | 2007 | Annals of Glaciology2007，46，： | 1 |
| 6 | Psychometricproperties of the Cyberbullying Questionnaire (CBQ) among Mexicanadolescents显示文摘 | G MEZ-GUADIX M VILLA-GEORGE F CALVETE E | 2014 | Viol Vict2014，29，2： | 1 |
| 7 | Influence of porcine spermadhesins on the susceptibility of boar spermatozoa to high dilution显示文摘 | CENTURION F VAZQUEZ J M CALVETE J J | 2003 | Biology of Reproduction2003，69，： | 1 |
| 8 | In vitro activityagainst anaerobes of retapamulin,a new topical antibi-otic for treatment of skin infections显示文摘 | Odou M F?Muller C? Calvet L | 2007 | J AntimicrobChemother2007，59，4： | 1 |
| 9 | Effect of sucralfate on gastric intramucosal pH in critically ill patients 显示文摘 | Calvet X Baigorri F Duarte M | 1997 | Intensive Care Med1997，23，7： | 1 |
| 10 | Synthesis of polysubsti- tuted 5-azaindoles via palladium-catalyzed heteroannula- tion of diarylalkynes 显示文摘 | Calvet G Liveeehi M Sehmidt F | 2011 | J Org Chem2011，76，11： | 1 |
| 11 | Beachroeks from the island of La Palma (Canary Islands, Spain) 显示文摘 | Calvet F Cabrer M C Carracedo J C | 2003 | Mar Geol2003，197，： | 1 |
| 12 | Sequential therapy for Helicobacter pylori eradication: A critical review显示文摘 | GISBERT J P CALVET X MEGRAUD F | 2010 | J Clin Gas- troentcrol2010，44，5： | 1 |
| 13 | Growth of single freestanding multiwall carbon nanotube on each nanonickel dot 显示文摘 | REN Z F HUANG Z P WANG D Z WEN F G XU J W WANG J H CALVET L E CHEN J KLEMIC J F REED M A | 1999 | Appl Phys Lett1999，75，： | 1 |
| 14 | Effect of sucralfate on gastric intramucosal pH in critically ill patients显示文摘 | Calvet X Baigorri F Duarte M | 1997 | Intensive Care Med1997，23，7： | 1 |
| 15 | Application of aqai stalks as biosorbents for the removal of the dyes Reactive Black 5 and Reactive Orange 16 from aqueous solution显示文摘 | Cardoso N F Lima E C Calvete T | 2011 | Journal of Chemical & Engineering Data2011，56，5： | 1 |
| 16 | Antibiotic resistance among anaerobic Gram - negative bacilli : lessons from a French rouhicentric survey 显示文摘 | Behra - Miellet J Calvet L Mory F | 2003 | Anaerobe2003，9，3： | 1 |
| 17 | Contribution of SiO2 in neutron-induced SEU in SRAMs显示文摘 | WROBEL F PALAU J M CALVET M C | 2003 | IEEE Trans Nucl Sci2003，50，6： | 1 |
| 18 | Applica- tion of carbon adsorbents prepared from Brazilian-pine fruit shell for the removal of reactive orange 16 from aque- ous solution : kinetic, equilibrium, and thermodynamic studies 显示文摘 | CALVETE T LIMA E C CARDOSO N F | 2010 | J Environ Manage2010，91，8： | 1 |
| 19 | Optimising acid inhibition treatment显示文摘 | Gomollon F’Calvet X | 2005 | Drugs2005，65，1： | 1 |
| 20 | Antibiotic resistance among anaerobic Gram-negative bacilli:lessons from a French multicentric survey显示文摘 | Behra MJ Calvet L Mory F | 2003 | Anaerobe2003，9，3： | 1 |
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