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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 3 | Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance 显示文摘 | Cao X Cai SF Fehniger TA Song J Collins LI Piwnica-Worms DR | 2007 | Immunity2007，27，63： | 1 |
| 4 | Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance 显示文摘 | Cao X Cai SF Fehniger TA | 2007 | Immunity2007，27，： | 1 |
| 5 | Glutamate receptors in the raphe pallidus me- diate brown adipose tissue thermogenesis evoked by activation of dorso- medial hypothalamic neurons 显示文摘 | Cao WH Morrison SF | 2006 | Neuropharmacology2006，51，3： | 1 |
| 6 | Effects of storage temperature on textural properties of Chinese bayberry fruit显示文摘 | Yang ZF Zheng YH Cao SF | | 0，，： | 1 |
| 7 | Granzyme B and perforin are im-portant for regulatory T cell-mediated suppression of tumor clearance 显示文摘 | Cao X Cai SF Fehniger TA | 2007 | Immunity2007，27，4： | 1 |
| 8 | Silencing of PCDH10 in hepatocellular carcinoma via de novo DNA methylation independent of HBV infection or HBX expression显示文摘 | Fang S Huang SF Cao J | | 0，，02： | 1 |
| 9 | Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance 显示文摘 | Cao XF Cai SF Fehniger TA | 2007 | hnmunity2007，27，4： | 1 |
| 10 | Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance显示文摘 | Cai SF Fehniger TA | 2007 | Immunity2007，27，4： | 1 |
| 11 | Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance显示文摘 | Cao X Cai SF Fehniger TA | 2007 | Immunity2007，27，： | 1 |
| 12 | Report of the Consensus Conference on diagnostic criteria of ALI/ARDS at high altitudes in western China显示文摘 | Zhang SF Lin SX Cao W | 2001 | Intrensive Care Med2001，27，： | 1 |
| 13 | Effect of methyl jas-monate on the inhibition of Colletotrichum acutatum infectionin loquat fruit and the possible mechanisms显示文摘 | Cao SF Zheng YH Yang ZF | 2008 | PostharvestBiology and Technology2008，49，： | 1 |
| 14 | Methyl jasmonate reducesdecay and enhances antioxidant capacity in Chinese bayber-ries显示文摘 | Wang KT Jin P Cao SF | 2009 | Journal of Agricultural Food Chemistry2009，57，： | 1 |
| 15 | Overexpression ofuroki-nase-type plasminogen activator in pterygia and pterygium fibrob-lasts显示文摘 | Cao SC Hu DN Yang PY Lin CY Yang SF | | 0，，17： | 1 |
| 16 | Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance显示文摘 | Cao X Cai SF Fehniger TA | 2007 | Immunity2007，27，4： | 1 |
| 17 | First report of clinical and epidemiological characterisation of vancomycin-resistant enterococci from mainland China显示文摘 | Cao B Liu YM Song SF | 2000 | Int J Antimicrob Agents2000，32，： | 1 |
| 18 | Effect of high oxygen atmosphere storage on quality, antioxidant enzymes, and DPPH-radical scavenging activity of Chinese bayberry fmit显示文摘 | Yang ZF Zheng YH Cao SF | 2009 | J Agric Food Chem2009，57，1： | 1 |
| 19 | Quality and physiological responses of Chinese bayberry fruit to storage tempera- ture显示文摘 | Yang ZF Cao SF Jin P | 2010 | J Hortic Sci Biotechnol2010，85，4： | 1 |
| 20 | Prevention and management of pressure ulcers in critical patients显示文摘 | Lo SF Chang LJ Cao WY | 2012 | Hu Li Za Zhi2012，59，4： | 1 |
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