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| 1 | Inflammation and colorectal cancer, when microbiota-host mutualism breaks显示文摘Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal cancer.In this review we discuss recent hypotheses on the mechanisms involved in the bacteria-mediated carcinogenesis,as well as the triggering factors favoring the shift of the gut microbiota from a mutualistic to a pro-carcinogenic configuration.The possible role of inflammation,bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically discussed.On the other hand,the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is suggested.As a common outcome of different environmental and endogenous triggers,such as diet,aging,pathogen infection or genetic predisposition,inflammation can compromise the microbiota-host mutualism,forcing the increase of pathobionts at the expense of health-promoting groups,and allowing the microbiota to acquire an overall pro-inflammatory configuration.Consolidating inflammation in the gut,and favoring the bloom of toxigenic bacterial drivers,these changes in the gut microbial ecosystem have been suggested as pivotal in promoting carcinogenesis.In this context,it will become of primary importance to implement dietary or probiotics-based interventions aimed at preserving the microbiota-host mutualism along aging,counteracting deviations that favor a pro-carcinogenic microbiota asset. | Marco Candela Silvia Turroni Elena Biagi Franck Carbonero Simone Rampelli Carla Fiorentini Patrizia Brigidi | 2014 | World Journal of Gastroenterology2014，20，4： | 13 |
| 2 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 3 | Is there a role for systemic targeted therapy after surgical treatment for metastases of renal cell carcinoma?显示文摘Metastatic renal cell carcinoma(m RCC) is a challenging disease. Despite the new targeted therapies, complete remissions occur only in 1%-3% of the cases, and the most effective first-line treatment drugs have reached a ceiling in overall survival(ranging from 9 to 49 mo). Metastasectomy remains to be the only curative option in most patients with m RCC. Prognostic nomograms have been recently published, so we have tools to classify patients in risk groups, allowing us to detect the cases with the higher risk of recurrence after metastasectomy. Although sparse, there is some evidence of effectiveness of neoadjuvant targeted therapy before metastasectomy; but with an increase in surgical complications due to the effects of these new drugs in tissue healing. We have aimed to answer the question: Is there a role for systemic targeted therapy after surgical treatment for metastases of renal cell carcinoma? We have made a search in Pubmed database. As far as we know, evidence is low and it's based in case reports and small series of patients treated with adjuvant drugs after neoadjuvant therapy plus metastasectomy in cases of partial response to initial systemic treatment. Despite the limitations and high risk of bias, promising results and cases with longterm survival with this approach have been described. Two ongoing clinical trials may answer the question that concerns us. | Adrian Husillos Alonso Manuel Carbonero García Carmen González Enguita | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 4 | Prevalence and risk factors of Campylobacter infection in broiler flocks from southern Spain显示文摘 | Alicia Torralbo Carmen Borge Alberto Allepuz Ignacio García-Bocanegra Samuel K. Sheppard Anselmo Perea Alfonso Carbonero | 2014 | Preventive Veterinary Medicine2014，，： | 2 |
| 5 | An unusual water - soluble β - glucan from the basidioearp of the fungus Gmaoderma Resinaceum显示文摘 | AMARAL A E CARBONERO E R DE SIMAO R C G | 2008 | Carbohydrtne Polymers2008，72，3： | 1 |
| 6 | A gel - forming β -glucan isolated From the fruit bodies of the edible mushroom Pleurotus florida 显示文摘 | SANTOS - NEVES J C PEREIRA M I CARBONERO E R | 2008 | Carbohydrate Research2008，343，9： | 1 |
| 7 | The family of DOF transcription factors in Brachypodiurn distachyon:phylogenetic comparison with rice and harley DOFs and expression profiling 显示文摘 | Hernando-Amado S Gonz61ez-Calle V Carbonero P | 2012 | BMC Plant Biology2012，12，1： | 1 |
| 8 | Two cold-inducible genes encoding lipid transfer protein LTP4 from barley show differential responses to bacterial pathogens显示文摘 | A. Molina I. Diaz P. Carbonero F. García-Olmedo I. K. Vasil | 1996 | MGG Molecular & General Genetics (-)1996，，1： | 1 |
| 9 | A β-glucan from the fruit bodies of edible mushrooms Pleurotus eryngii and Ple urotus ostreatorose us 显示文摘 | Carbonero E R Gracher A H P Smiderle F R | 2006 | Carbohydrate Polymers2006，66，2： | 1 |
| 10 | Structural characterization and protective effect against murine sepsis of fucogalactans from Agaricus bisporus and Lactarius ru- fus 显示文摘 | RUTHES A C RATI'MANN Y D CARBONERO E R | 2012 | Carbohydrate Polymers2012，87，2： | 1 |
| 11 | Upper digestive tract hemorrhage in a child with heterotopic pancreas in a gastric diverticulum 显示文摘 | Carbonero - Celis MJ Romero - Morita H Northrop - Sharp B | 2013 | Revista Espanola De Enfermedades Digestivas Orga- no Oficial De La Sociedad Espanola De Patologia Digesti- va2013，105，1： | 1 |
| 12 | Characterization of a heterogalactan:Some nutritional values of the edible mushroom Flammulina velutipes显示文摘 | Smiderle F R Carbonero E R Sassaki G L | 2008 | Food Chemistry2008，108，1： | 1 |
| 13 | Liver cirrhosis in HIV‐infected patients: prevalence, aetiology and clinical outcome显示文摘 | C.Castellares P.Barreiro L.Martín‐Carbonero P.Labarga M. E.Vispo R.Casado L.Galindo P.García‐Gascó J.García‐Samaniego V.Soriano | 2007 | Journal of Viral Hepatitis2007，，3： | 1 |
| 14 | Differential expression of pathogen-responsive genes encoding two types of glycine-rich proteins in barley 显示文摘 | Molina A Mena M Carbonero P | 1997 | Plant Mol Biol1997，33，： | 1 |
| 15 | Genome-wide comparative phylogenetic analysis of the rice and Arabidopsis Dof gene families显示文摘 | Lijavetzky D Carbonero P Vicente-Carbajosa J | 2003 | BMC Evol Biol2003，3，： | 1 |
| 16 | Comparison of diagnostic techniques for porcine proliferative enteropathy (Lawsonia intracellularis infection)显示文摘 | Huerta B Arenas A Carrasco L Maldonado A Tarradas C Carbonero A Perea A | 2003 | J Comp Pathol2003，129，23： | 1 |
| 17 | Characterization of a heterogalactan: Some nutritional values of the edible mushroom Flamrnulina velutipes显示文摘 | SMIDEILLE FR CARBONERO EtL SASSAKI GL | 2008 | Food Chem2008，108，1： | 1 |
| 18 | Proanostic value of KIT expressoin in small cell lung canc- er显示文摘 | L6pez - Martin A Ballestfn C Garcia - Carbonero R | 2007 | Lung Cancer2007，56，3： | 1 |
| 19 | Incidence, patterns of care and prognostic factors forouteome of gastroenteropancre- atic neuroendocrine tumors (GEP NETs): results from the National Cancer Registry of Spain (RGETNE) 显示文摘 | Garcia Carbonero R Capdevila J Crespo Herrero G | 2010 | Ann Oncol2010，21，9： | 1 |
| 20 | A novel branched αβ-glucan isolated from the basidiocarps of the edible mushroom Pleurotus florida 显示文摘 | Santos-Neves J C Pereira M I Carbonero E R | 2008 | Carbohydrate Polymers2008，73，： | 1 |
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