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| 1 | Reduction of the closure time of postoperative enterocutaneous fistulas with fibrin sealant显示文摘AIM: To assess whether the use of fibrin sealantshortens the closure time of postoperative enterocutaneous fistulas (ECFs). METHODS: The prospective case-control study included 70 patients with postoperative ECFs with an output of < 500 mL/d, a fistulous tract of > 2 cm and without any local complication. They were divided into study (n = 23) and control groups (n = 47). Esophageal, gastric and colocutaneous fistulas were monitored under endoscopic visualization, which also allowed fibrin glue application directly through the external hole. Outcome variables included closure time, time to resume oral feeding and morbidity related to nutritional support. RESULTS: There were no differences in mean age, fistula output, and follow-up. Closure-time for all patients of the study group was 12.5 ± 14.2 d and 32.5 ± 17.9 d for the control group (P < 0.001), and morbidity related to nutritional support was 8.6% and 42.5%, respectively (P < 0.01). In patients with colonic fistulas, complete closure occurred 23.5 ± 19.5 d after the first application of fibrin glue, and spontaneous closure was observed after 36.2 ± 22.8 d in the control group (P = 0.36). Recurrences were observed in 2 patients because of residual disease. One patient of each group died during follow-up as a consequence of septic complications related to parenteral nutrition. CONCLUSION: Closure time was significantly reduced with the use of fibrin sealant, and oral feeding was resumed faster. We suggest the use of fibrin sealant for the management of stable enterocutaneous fistulas. | Jorge Avalos-González Eliseo Portilla-deBuen Caridad Aurea Leal-Cortés Abel Orozco-Mosqueda María del Carmen Estrada-Aguilar Gabriela Abigail Velázquez-Ramírez Gabriela Ambriz-González Clotilde Fuentes-Orozco Aldo Emmerson Guzmán-Gurrola Alejandro González-Ojeda | 2010 | World Journal of Gastroenterology2010，16，22： | 10 |
| 2 | Post-traumatic hepatic artery pseudoaneurysm treated with endovascular embolization and thrombin injection显示文摘Post-traumatic hepatic artery pseudoaneurysm is unc-ommon,appearing in approximately 1%of hepatic trauma cases.Most are extrahepatic(80%)and have a late onset.Although they are usually asymptomatic, they should always be treated becasue of the high risk of complications,especially breakage.Currently the treatment of choice is endovascular embolization with coils or the exclusion of the pseudoaneurysm using other intravascular devices.Recently there have been accounts of a treatment that combines embolization with coils and image-guided percutaneous human thrombin injection.We present a case of post-traumatichepatic artery pseudoaneurysm that was successfully treated using this combined technique. | Lloret Esta Francisco López Conesa Asunción Capel Alemán Antonio Robles Campos Ricardo Reus Pintado Manuel Marín Hernández Caridad | 2010 | World Journal of Hepatology2010，2，2： | 9 |
| 3 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 4 | Pan-retinal ganglion cell markers in mice, rats, and rhesus macaques显示文摘Univocal identification of retinal ganglion cells(RGCs) is an essential prerequisite for studying their degeneration and neuroprotection. Before the advent of phenotypic markers, RGCs were normally identified using retrograde tracing of retinorecipient areas. This is an invasive technique, and its use is precluded in higher mammals such as monkeys. In the past decade, several RGC markers have been described. Here, we reviewed and analyzed the specificity of nine markers used to identify all or most RGCs, i.e., pan-RGC markers, in rats, mice, and macaques. The best markers in the three species in terms of specificity, proportion of RGCs labeled, and indicators of viability were BRN3A, expressed by vision-forming RGCs, and RBPMS, expressed by vision-and non-vision-forming RGCs. NEUN, often used to identify RGCs, was expressed by non-RGCs in the ganglion cell layer, and therefore was not RGC-specific. γ-SYN, TUJ1, and NF-L labeled the RGC axons, which impaired the detection of their somas in the central retina but would be good for studying RGC morphology. In rats, TUJ1 and NF-L were also expressed by non-RGCs. BM88, ERRβ,and PGP9.5 are rarely used as markers, but they identified most RGCs in the rats and macaques and ERRβ in mice. However, PGP9.5 was also expressed by non-RGCs in rats and macaques and BM88 and ERRβ were not suitable markers of viability. | Francisco M.Nadal-Nicolás Caridad Galindo-Romero Fernando Lucas-Ruiz Nicholas Marsh-Amstrong Wei Li Manuel Vidal-Sanz Marta Agudo-Barriuso | 2023 | Zoological Research2023，44，1： | 2 |
| 5 | Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury:focus on the visual system显示文摘The retina,as part of the central nervous system is an ideal model to study the response of neurons to injury and disease and to test new treatments.During the last decade is becoming clear that unilateral lesions in bilateral areas of the central nervous system trigger an inflammatory response in the contralateral uninjured site.This effect has been better studied in the visual system where,as a rule,one retina is used as experimental and the other as control.Contralateral retinas in unilateral models of retinal injury show neuronal degeneration and glial activation.The mechanisms by which this adverse response in the central nervous system occurs are discussed in this review,focusing primarily on the visual system. | Fernando Lucas-Ruiz Caridad Galindo-Romero Virginia Albaladejo-García Manuel Vidal-Sanz Marta Agudo-Barriuso | 2021 | Neural Regeneration Research2021，16，11： | 2 |
| 6 | From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?显示文摘Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide.Clinically,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons.Current treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal damage.Therefore,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's disease.For instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell death.Despite the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative process.Therefore,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based strategies.Stem cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease,given its ability to modulate cell viability/preservation of dopaminergic neurons.Such approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's disease.Thus,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson's disease. | Rita Caridade Silva Helena Sofia Domingues António J.Salgado Fábio G.Teixeira | 2022 | Neural Regeneration Research2022，17，5： | 2 |
| 7 | CFD analysis of electric submersible pumps(ESP) handling two-phase mixtures显示文摘 | Jose Caridad Frank Kenyery | 2004 | Transaction of the ASME:Journal of Energy Resource Technology2004，126，2： | 1 |
| 8 | Efficacy of two peroxygen-based disinfectants for inactivation of cryptosporidium parvum oocysts 显示文摘 | JOAQUIN Q CARIDAD S A CATALINA A | 2006 | Applied and Environmental Microbiology2006，71，5： | 1 |
| 9 | Critically ill patients with cancer: A clinical perspective显示文摘Cancer patients account for 15%of all admissions to intensive care unit(ICU)and 5%will experience a critical illness resulting in ICU admission.Mortality rates have decreased during the last decades because of new anticancer therapies and advanced organ support methods.Since early critical care and organ support is associated with improved survival,timely identification of the onset of clinical signs indicating critical illness is crucial to avoid delaying.This article focused on relevant and current information on epidemiology,diagnosis,and treatment of the main clinical disorders experienced by critically ill cancer patients. | Frank Daniel Martos-Benítez Caridad de Dios Soler-Morejón Karla Ximena Lara-Ponce Versis Orama-Requejo DailéBurgos-Aragüez Hilev Larrondo-Muguercia Rahim W Lespoir | 2020 | World Journal of Clinical Oncology2020，11，10： | 1 |
| 10 | Stimuli-resexmsive ehitosan-starch injectable hydrogels combined with encapsulated adipose-derived stromal cells for articular cartilage regenerauon显示文摘 | Sa-Lima H Caridade S G Mano J F | 2010 | Soft Matter2010，6，： | 1 |
| 11 | New poly(e-capro- lactone)/chitosan blend fibers for tissue engineering applications 显示文摘 | Malheiro VN Caridade SG Alves NM | 2010 | Acta Biomater2010，6，2： | 1 |
| 12 | CFD analysis of electric submersible pumps(EPS) handing two-phase mixtures 显示文摘 | CARIDAD J KENYERY F | 2004 | Transaction of the ASME: Journal of Energy Re- source Technology2004，126，2： | 1 |
| 13 | Free-standing polyelectrolyte membranes made of chitosan and alginate显示文摘 | Caridade S G Monge C Gilde F | 2013 | Biomacromolecules2013，14，5： | 1 |
| 14 | Late polymicrobial transjugular intrahepatic portosystemic shunt infection in a liver transplant patient:A case report显示文摘BACKGROUND Infection of a transjugular intrahepatic portosystemic shunt(TIPS)stent is a rare and serious complication that most commonly occurs during TIPS creation and revision.Patients typically present with recurrent bacteremia due to shunt occlusion or vegetation.To date there are approximately 58 cases reported.We present a patient diagnosed with late polymicrobial TIPS infection five years following TIPS creation.CASE SUMMARY A 63-year-old female status-post liver transplant with recurrent cirrhosis and portal hypertension presented with sepsis and recurrent extended-spectrum betalactamase Escherichia coli bacteremia.Computed tomography of the abdomen revealed an occluded TIPS with thrombus extension into the distal right portal vein,and focal thickening of the cecum and ascending colon.Colonoscopy revealed patchy ulcers in these areas with histopathology demonstrating ulcerated colonic mucosa with fibrinopurulent exudate.Shunt thrombectomy and revision revealed infected-appearing thrombus.Patient initially cleared her infection with antibacterial therapy and TIPS revision;however,soon after,she developed Enterobacter cloacae bacteremia and Candida glabrata and C.albicans fungemia with recurrent TIPS thrombosis.She remained on antifungal therapy indefinitely and later developed vancomycin-resistant Enterococcus faecium with recurrent TIPS thrombosis.The option of liver re-transplant for removal of the infected TIPS was not offered given her critical illness and complex shunt anatomy.The patient became intolerant to linezolid and elected hospice care.CONCLUSION Clinicians should be aware that TIPS superinfection may occur as long as five years following TIPS creation in an immunocompromised patient. | Irene De La Caridad Perez Ziv J Haskal John I Hogan Curtis K Argo | 2022 | World Journal of Hepatology2022，14，4： | 1 |
| 15 | Role of ICAM-1 in invasion of human ovarian cancer ceils 显示文摘 | Caridad Rosette Richard B Roth Paul Oeth | 2005 | Carcinogenesis2005，26，5： | 1 |
| 16 | Cumulative Corticosteroid Exposure and Infection Risk After Complex Pediatric Cardiac Surgery显示文摘 | Christopher W. Mastropietro Renee Barrett Maria Caridad Davalos Marwan Zidan Kevin M. Valentine Ralph E. Delius Henry L. Walters | 2013 | The Annals of Thoracic Surgery2013，，6： | 1 |
| 17 | Effectiveness of early beta interferonon the first attack after confirmed multiplesclerosis :a compara- tive cohort study显示文摘 | Mikaeloff Y Caridade G Tardieu M Suissa S | 2008 | Eur J Paediatr Neurol2008，12，3： | 1 |
| 18 | Free-standing polyelectrolyte membranes made of chitosan and alginate显示文摘 | Caridade S G Monge C Gilde F | 2013 | Biomacromolecules2013，14，5： | 1 |
| 19 | CFD analysis of electric submersible pumps ( EPS ) handing two-phase mixtures 显示文摘 | Caridad J Kenyery F | 2004 | Transaction of the ASME: Journal of Energy Resource Technology2004，126，2： | 1 |
| 20 | Mechanisms under- lying CD4+ treg immune regulation in the adult: From experiments to models显示文摘 | Caridade M Graca L Ribeiro RM | 2013 | Front Immunol2013，18，4： | 1 |
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