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| 1 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 2 | Out-of-hospital cardiac arrest and airborne fine particulate matter:a case-crossover analysis f emergency medical services data in Indianapolis,Indiana显示文摘 | ROSENTHAL F S CARNEY J P OLINGER M I | 2008 | Environ Health Perspect2008，116，5： | 1 |
| 3 | Inactivation of multiple viru- lence genes reduces the ability of Pseudomonas sdanacearum to cause wilt symptoms显示文摘 | Denny T P Carney B F Schell M A | 1990 | Molecular Plant Microbiology Interac- tion1990，3，5： | 1 |
| 4 | Thin, LightweightElectroacoustic Projector for Low Frequency UnderwaterApplications显示文摘 | Tressler J F Howarth T R Carney W L | 2004 | The Jounal of The Acoustical Society of America2004，116，3： | 1 |
| 5 | History of depression and survival after acute myocardial infarction显示文摘 | Carney R M Freedland K F Steinmeyer B | | 0，，03： | 1 |
| 6 | Sulfide binding is mediated by zinc ions discovered in the crystal structure of a hydrothermal vent tubeworm hemoglobin 显示文摘 | Flores J F Fisher C R Carney S L | 2005 | Proceedings of the National Academy of Sciences of the United States of America2005，102，： | 1 |
| 7 | CD200 fusion protein decreases microglial activation in the hippocampus of aged rats显示文摘 | Cox F F Carney D Miller A M | | 0，，： | 1 |
| 8 | Nicotin regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor显示文摘 | Serres F Carney SL | 2006 | Brain Res2006，1101，1： | 1 |
| 9 | High-velocity impact of graphite/epoxy composite laminates 显示文摘 | Chen J K Allahdadi F A Carney T C | 1997 | Compos Sci Technol1997，57，910： | 1 |
| 10 | High strain Lagrangian hydrodynamicsa three-di mensional SPH cde for dynamic material response显示文摘 | Libersky L D Petscheck A G Carney T C Hipp J R Allah dadi F A | 1993 | Jour nal of Computational Physics1993，109，： | 1 |
| 11 | Time and frequency domain methods for heart rate variability analysis:A methodological comparison显示文摘 | Litvack D A Oberlander T F Carney L H | 1995 | Psychophysiology1995，32，5： | 1 |
| 12 | Association ofdepression with teduced heart rate variability in coronary ar-tery disease显示文摘 | Carney R M Saunders R D Freedland K F | 1995 | Am J Cardiol1995，76，8： | 1 |
| 13 | Bone: modulation of IGF1 might prevent osteoporosis显示文摘 | Carney E F | 2012 | Nat Rev Rheumatol2012，8，8： | 1 |
| 14 | Inactivation of multiple virulence genes reduces the ability of Pseudomonas solanacearum to cause wilt symptoms 显示文摘 | Denny T P B F Carney M A Schell | 1990 | Mol Plant-Microbe Interact1990，3，： | 1 |
| 15 | High strain Lagrangian hydrodynamics -- A three-dimensional SPH code for dynamic material response 显示文摘 | Libersky L D Petschek A G Carney T C Hipp J R Allahdadi F A | 1993 | Journal of Computational Physics1993，109，1： | 1 |
| 16 | Ecological potentials of species of Rozella (Cryptomycota) 显示文摘 | Gleason F H Carney L T Lilje O | 2012 | Fung Ecol2012，5，6： | 1 |
| 17 | Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor显示文摘 | Serres F Carney S L | 2006 | Brain Res2006，1101，1： | 1 |
| 18 | Oxidative damage in rainbow trout caged in a polluted river显示文摘 | Carney Almroth B Sturve J F(o)rlin L | | 0，，01： | 1 |
| 19 | Raman and resonance Raman spectroscopy of selected rare-earth sesquioxides显示文摘 | Tucker L A Carney F J McMillan P Lin S H Eyring L | | 0，，： | 1 |
| 20 | Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor显示文摘 | CARNEY SL | 2006 | Brain Res2006，1101，1： | 1 |
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