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| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 3 | Catalytic reduction of nitrate and nitrite on Pt- Cu/Al2O3 catalysts in aqueous solution:role of the interaction between copper and platinum in the reaction显示文摘 | Florence E Florence G Carole P | 2001 | Journal of Catalysis2001，198，： | 3 |
| 4 | Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells: Physiological and Therapeutic Perspectives显示文摘 | Valérie Planat-Benard Jean-Sébastien Silvestre Béatrice Cousin Mireille André Maryse Nibbelink Radia Tamarat Michel Clergue Carole Manneville Corinne Saillan-Barreau Micheline Duriez Alain Tedgui Bernard Levy Luc Pénicaud Louis Casteilla | 2004 | Circulation: Journal of the American Heart Association2004，，5： | 2 |
| 5 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet2005，，9503： | 2 |
| 6 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet . 2005 (9503)2005，，9503： | 2 |
| 7 | Geometric damage tensor based on microplane model 显示文摘 | Carol I BaZant Z E Prat P C | 1991 | Journal of Engineering Mechanics1991，117，10： | 1 |
| 8 | Negative pH and extremely acidic mine waters from ironmountain, Califomia显示文摘 | DARRELL K N CHARLES N A CAROL J P DAVID W B | 2000 | Environmental Science and Technology2000，34，： | 1 |
| 9 | Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program显示文摘 | Lock r Carol H Houghton P J | | 0，，06： | 1 |
| 10 | New explicit microplane model for concrete: Theoretical aspects and numerical implementation 显示文摘 | Carol I Prat P C Bazant Z P | 1992 | International Journal of Solids and Structures1992，29，9： | 1 |
| 11 | Market structure and prices: the responses of hospitals in the UK national health service to competition显示文摘 | Carol P | 1996 | J''ournal of Health Economics1996，61，： | 1 |
| 12 | The Haddon matrix:Applying an epidemiologic research tool as a framework for death inveatigation显示文摘 | Conroy Carol M P H Fowler John B S | 2000 | The America Journal of Forensic Medicine and Pathalogy2000，21，04： | 1 |
| 13 | Role of Cbfa1/Runx2 in the fluid shear stress induction of COX-2 in osteoblasts显示文摘 | Meenal M Masatomo S Carol P | 2006 | Biochem Biophys Res Commun2006，341，4： | 1 |
| 14 | Silica in plants: biological,biochemical and chemical studies显示文摘 | HEATHER A C CAROLE C P | 2007 | Annals of Botany2007，100，7： | 1 |
| 15 | Development and operations of the EO-1 hyperion imaging spectrometer显示文摘 | Jay P Carol S Liao L | 2004 | SPIE2004，4135，： | 1 |
| 16 | Viscoelasticity with aging caused by solidification of nonaging constituent 显示文摘 | Carol I Assocate Members ASCE F Bazant Z P | 1992 | Journal of Engineering Mechanics1992，119，11： | 1 |
| 17 | Development and validation orocessesfor an objective structured clinical examination ( OSCE) for entry - to -practice certification in pharmacy : the Canedian experience 显示文摘 | ZubinA Carol 0 B John P | 2003 | Am JPharm Educ2003，67，3： | 1 |
| 18 | Development and validation oro- cesses for an objective structured clinical examination(OSCE) for entry-to-practice certification in pharmacy: the Canadian experience 显示文摘 | Zubin A Carol OB John P | 2003 | A m J Pharm Educ2003，67，3： | 1 |
| 19 | Mutations in the Arabidopsis gene IMMUTANS cause a variegated phenotype by inactivating a chloroplast terminal oxidase associated with phytoene desaturation 显示文摘 | Carol P Stevenson D Bisanz C | 1999 | The Plant Cell1999，11，： | 1 |
| 20 | Development and validation or ocesses for an objective structured clinical examination(OSCE)for entry-to-practice certification in pharmacy:the Canadian experience显示文摘 | Zubin A Carol OB John P | | 0，，03： | 1 |
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