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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression. | Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini | 2010 | World Journal of Gastroenterology2010，16，3： | 6 |
| 3 | Delayed spontaneous reversibility of left bundle branch block in non-ischemic cardiomyopathy: a case report显示文摘Left bundle branch block(LBBB)causes a delay in left ventricular contraction with an unsynchronized ventricular systole.LBBB is an independent determinant of morbi-mortality mainly when associated with cardiomyopathy and left ventricular dysfunction.[1] LBBB due to non-ischemic cardiomyopathy is considered non-reversible.Such irreversibility occurs because LBBB and cardiomyopathy act in a synergic manner in order to maintain both situations.However,there are a few reports in the literature showing that some patients have had an improvement in cardiac function with normalization of QRS and have experienced a reverse remodelling with pharmacological therapy only.[2–4] | Marcus VH Carvalho Priscila C Kroll Vinicius N Carvalho | 2020 | Journal of Geriatric Cardiology2020，17，3： | 2 |
| 4 | Contrasted effect of biochar and earthworms on rice growth and resource allocation in different soils显示文摘 | Diana Noguera Marco Rondón Kam-Rigne Laossi Valerio Hoyos Patrick Lavelle Maria Helena Cruz de Carvalho Sébastien Barot | 2010 | Soil Biology and Biochemistry2010，，7： | 2 |
| 5 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 6 | Energetic-protein supplementation in the last 60 days of gestation improves performance of beef cows grazing tropical pastures显示文摘Background: Nutrition is one of the most important factors that affect animal performance, and it therefore also impacts on financial results in beef systems. In this way, finding the best strategy for feeding supplements is of paramount importance. Aiming to evaluate the effect of supplement feeding strategies for beef cows in the last third of gestation, two experiments were conducted. In Experiment 1, 35 pregnant Nellore cows were assigned to a completely randomized design with four treatments: control, which received no supplement; supplementation for the last 30 d of gestation(30-d; 3.0 kg/d); supplementation for the last 60 d of gestation(60-d; 1.5 kg/d); or supplementation for the last 90 d of gestation(90-d; 1.0 kg/d). All supplemented treatments received the same total amount of supplement throughout the experiment: 90 kg(20% of crude protein). A second experiment(Experiment 2) was delineated to evaluate the effects of the amounts offered in Experiment 1 on intake and metabolism. Four multiparous pregnant Nellore cows were assigned to a 4 × 4 Latin square design, with periods of15 d each.Results: There was a linear effect of the number of days of supplementation on calving body weight(BW; P < 0.05)and a quadratic effect on BW change from parturition to d 31 post-calving(P < 0.05), with cows on the 60-d strategy losing less BW post-calving. No difference was found in offspring birth BW(P > 0.10). A significant linear effect on interval from parturition to conception(P < 0.05) was observed, with the highest calving to conception interval being observed in the 90-d strategy. The level of supplementation did not affect forage intake or neutral detergent fiber digestibility(P > 0.10). Nitrogen excreted through urine tended to increase linearly with the level of supplementation(P < 0.10).Conclusion: Providing 1.5 kg of supplement during the last 60 d of gestation improves cow performance after calving, reducing the magnitude of BW lost, and reduces the number of days from calving to re-conception in the following breeding season compared to the usually recommended period of supplementation of 90 d pre-partum. | Aline Gomes da Silva Mário Fonseca Paulino Edenio Detmann Henrique Jorge Fernandes Lincoln da Silva Amorim Román Enrique Maza Ortega Victor Valério de Carvalho Josilaine Aparecida da Costa Lima Felipe Henrique de Moura Mariana Benevides Monteiro Jéssika Almeida Bitencourt | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 2 |
| 7 | Fructosyl transferase and hydrolase activities in rhizophores and tuberous roots upon growth of Polymnia sonchifoliu ( Asteraceae ) 显示文摘 | Itaya N M De Carvalho M A M Figueiredo-Ribeiro R D L | 2002 | Physiol Plant2002，116，4： | 1 |
| 8 | An expeditiousmethod for the determ ination of organochlorine pesticides resi-dues in estuarine sediments using microwave assisted pre-ex-traction an d automa ted headspace solid phase microextractioncoupled to gas chromatography-mass spectrometry显示文摘 | Carvalho P N Rodrigues P N R Alves F | 2008 | Talan-ta2008，76，5： | 1 |
| 9 | Type Ⅱ callus production and plant regeneration in tropical maize genotypes显示文摘 | Carvalho CHS Bohorova N Bordallo PN | 1997 | Plant Cell Reports1997，17，1： | 1 |
| 10 | Effect of PUFA-rich supplements from marine sources in the feed of laying hens on lipid composition and the percent- age of incorporation of n-6 PUFAs in egg yolk 显示文摘 | CARVALHO P R PITA M C G PIBER N E | 2009 | Ar- quivous do Instituto Biologico2009，76，2： | 1 |
| 11 | Physical exercise reduces circulating lipopolysaccharide and TLR4 activation and improves insulin signaling in tissues of DIO rats 显示文摘 | Oliveira AG Carvalho BM Yobar N | 2011 | Diabetes2011，60，3： | 1 |
| 12 | Investigation on the formation of tungsten carbide in tungsten-containing diamond like carbon coatings显示文摘 | Strondl C Carvalho N M Hosson J Th M De | 2003 | Surface and Coatings Technology2003，162，23： | 1 |
| 13 | Unique (Y; 13 ) translocation in a male with oligozoospermia: eytogenetie and molecular studies显示文摘 | Alves C Carvalho F Cremades N | 2002 | Eur J Hum Genet2002，10，： | 1 |
| 14 | OmpC and the sigma E regulatory pathway are involved in adhesion and invasion of the Crohn's disease-associated Escherichia cell strain LF82显示文摘 | Rolhion N Carvalho FA Darfeuille-Michaud A | 2007 | Molecular Microbiology2007，63，6： | 1 |
| 15 | Glossepharyngeal neuralgia with syncope as a sign of neck cancer recurrence显示文摘 | Ribeiro RT Amorim de Souza N Carvalho Dde S | 2007 | Arq Neuropsiquiatr2007，65，4： | 1 |
| 16 | Influence of aluminum in nutrient solutions on chemical composition in upland rice cultivars 显示文摘 | FAGERIA N K CARVALHO J R P | 1982 | Plant Soil1982，69，： | 1 |
| 17 | Ti3 SIC2: a damage tolerant ceramic studied with nano-indentations and transmission electron mi- croscopy 显示文摘 | Kooi B J Poppen R J Carvalho N J M | 2003 | Acta Materialia2003，51，10： | 1 |
| 18 | Glossopha- ryngeal neuralgia with syncope as a sign of neck cancer recur- rence 显示文摘 | Ribeiro RT Amorim de Souza N Carvalho Dde S | 2007 | Arq Neuropsiquiatr2007，65，4： | 1 |
| 19 | Biomass consumption and CO2,CO and main hydrocarbon gas emissions in an Amazonian forest clearing fire显示文摘 | Soares N T G Carvalho J A Lincoln E N | | 0，，02： | 1 |
| 20 | Optimum behavior: Wireless power transmission system design through be- havioral models and efficient synthesis techniques显示文摘 | Boaventura A Collado A Carvalho N B | 2013 | Microwave Magazine IEEE2013，，2： | 1 |
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