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| 1 | Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer:An update显示文摘The biosynthesis of prostanoids is involved in both physiological and pathological processes. The expression of prostaglandin-endoperoxide synthase 2(PTGS2; also known as COX-2) has been traditionally associated to the onset of several pathologies, from inflammation to cardiovascular, gastrointestinal and oncologic events. For this reason, the search of selective PTGS2 inhibitors has been a focus for therapeutic interventions. In addition to the classic non-steroidal anti-inflammatory drugs, selective and specific PTGS2 inhibitors, termed coxibs, have been generated and widely used. PTGS2 activity is less restrictive in terms of substrate specificity than the homeostatic counterpart PTGS1, and it accounts for the elevated prostanoid synthesis that accompanies several pathologies. The main regulation of PTGS2 occurs at the transcription level. In addition to this, the stability of the mRNA is finely regulated through the interaction with several cytoplasmic elements, ranging from specificmicroR NAs to proteins that control mR NA degradation. Moreover, the protein has been recognized to be the substrate for several post-translational modifications that affect both the enzyme activity and the targeting for degradation via proteasomal and non-proteasomal mechanisms. Among these modifications, phosphorylation, glycosylation and covalent modifications by reactive lipidic intermediates and by free radicals associated to the proinflammatory condition appear to be the main changes. Identification of these post-translational modifications is relevant to better understand the role of PTGS2 in several pathologies and to establish a correct analysis of the potential function of this protein in diseases progress. Finally, these modifications can be used as biomarkers to establish correlations with other parameters, including the immunomodulation dependent on molecular pathological epidemiology determinants, which may provide a better frame for potential therapeutic interventions. | Rafael I Jaén Patricia Prieto Marta Casado Paloma Martín-Sanz Lisardo Boscá | 2018 | World Journal of Gastroenterology2018，24，48： | 5 |
| 2 | Organometallics显示文摘 | Cuadrado I Morán M Casado C M | 1996 | 15:5 2781996，15，： | 1 |
| 3 | Informed Dynamic Scheduling for Belief-Propagation Decoding of LDPC Codes 显示文摘 | Vila Casado Andres I Griot Miguel Wesel Richard D | 2007 | IEEE International Conference on Communication2007，，： | 1 |
| 4 | Mineralization of Aromatics in Waterby Sunlight-Assisted Electro-Fenton Technology in a Pilot Reactor 显示文摘 | Casado J Fornaguera J Galán M I | 2005 | Environ Sci Technol2005，39，6： | 1 |
| 5 | Seed chitinases review显示文摘 | Gomez L Allona I Casado R | 2002 | Seecl Science Res earth2002，12，： | 1 |
| 6 | On An Efficient Use of Gradient Information for Accelerat ing Interval Global Optimization Algorithms显示文摘 | MartInez J A Casado L G Garcia I | 2004 | Numerical Algorithms2004，，37： | 1 |
| 7 | Continued declining incidence and improved survival of progressive multifocal leukoencephalopathy in HIV/AIDS patients in the current era显示文摘 | Casado JL Corral I Garcia J | 2013 | Eur J Clin Microbiol Infect Dis2013，33，2： | 1 |
| 8 | Experiments with a new selection criterion in a fast interval optimization algorithm显示文摘 | Martinez J A Garcia I | 2001 | Journal of Global Optimization2001，19，： | 1 |
| 9 | Transdermal glyceryl trinitrate for prevention of post-ERCP pancreatitls:a randomize double-bline trail 显示文摘 | Moreto M Zaballa M Casado I | 2003 | Gastrointest Endosc2003，57，1： | 1 |
| 10 | A Study of the Use of the Carlos III University of Madrid Library's Online Database Service in Scientific Endeavor显示文摘 | Carlos A S Maestro I Casado E S | 2003 | Information Technology and Libraries2003，，4： | 1 |
| 11 | Polycyclic aromatic hydrocarbons in soil and plant samples from the vicinity of an oil refinery显示文摘 | Bakker M I Casado B Koerselman J W | 2000 | The Science of the Total Environment2000，263，13： | 1 |
| 12 | Com- posite films based on shape memory polyurethanes and nano- structured polyaniline or cellulose-polyaniline particles显示文摘 | Casado U M Quintanilla R M Aranguren M I | 2012 | Synth Metals2012，162，17： | 1 |
| 13 | The value of thyroglobulin in washout of fine needle aspirate from 16 cervical lesions in patients with thyroid cancer 显示文摘 | FAMILIAR CASADO C ANTON Bravo T MORAGA GUERRERO I | 2013 | Endocrinol Nutr2013，60，9： | 1 |
| 14 | Dynamic behavior of railway fastening setting pads显示文摘 | Carrascal I A Casado J A Polanco J A | 2007 | Engineering Failure Analysis2007，，14： | 1 |
| 15 | Clinical importance of the CagA and VacA proteins and of the host factoresin the development of peptic ulcer in patients infected by Helwobacter pylori显示文摘 | Toro Rueda C Garcia-Samaniego J Casado Farinas I | 2003 | Rev Clin Esp2003，203，9： | 1 |
| 16 | The value of thyroglobulin in washout of fine needle aspirate from 16 cervical lesions in patients with thyroid cancer 显示文摘 | FAMILIAR CASADO C ANTON BRAVO T MORAGA GUERRERO I | 2013 | Endocrinol Nutr2013，60，9： | 1 |
| 17 | Clinical importance of the CagA and VacA proteins and of the host factoresin the development of peptic ulcer in patients infected by Helicobacter pylori显示文摘 | Garcia-Samaniego J Casado Farinas I | 2003 | Rev Clin Esp2003，203，9： | 1 |
| 18 | New interval analysis support functions using gradient information in a global minimization algorithm显示文摘 | Casado L G Martínez J A García I | 2003 | Journal of Global Optimization2003，25，4： | 1 |
| 19 | Absorption and Diffusion of Humidity in Fiberglass-Reinforced Polyamide显示文摘 | Carrascal I Casado J A Polanco J A | 2005 | Polymer Composites2005，26，5： | 1 |
| 20 | Effect of different matrices on physiological amino acids analysis by liquid chromatography: evaluation and correction of the matrix effect显示文摘 | FERNANDEZ-FIGARES I RODRIGUEZ L C GONZALEZ- CASADO A | 2004 | Journal of Chromatography B2004，799，1： | 1 |
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