|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Propolis effects on pro-inflammatory cytokine production and Toll-like receptor 2 and 4 expression in stressed mice显示文摘 | Ana Carolina Pagliarone Cláudio Lera Orsatti Michelle Cristiane Búfalo Fabiane Missima Tatiana Fernanda Bachiega Jo?o Pessoa Araújo Júnior José Maurício Sforcin | 2009 | International Immunopharmacology2009，，11： | 1 |
| 3 | A method for extracting the fundamental-frequency positive-sequence voltage vector based on simple mathematical transformations 显示文摘 | HELBER E FABR | 2009 | IEEE Transactions on industrial electronics2009，20，5： | 1 |
| 4 | The kinetics of pentoxifylline release in vivo from drug-loaded hydroxyapatite implants显示文摘 | Mycek B P | 2001 | Ceramics International2001，27，7： | 1 |
| 5 | Association ofPIT1 genotypes with growth traits in Canchim cattle显示文摘 | Sfinia M C Maurício M A Luiz B T | 2008 | Sci Agric2008，65，： | 1 |
| 6 | Replacing egg yolk with soybean lecithin in the cryopreservation of stallion semen显示文摘 | Papa F O Felício G B Melo-O珘na C M | 2011 | Anim Reprod Sci2011，129，12： | 1 |
| 7 | Influence of uric acid and '/-glutamyltransferase on total antioxidant capacity and oxidative stress in patients with metabolic syndrome显示文摘 | ANDRI~A C S JANE B D DI~CIO S B | 2008 | Nutrition2008，24，： | 1 |
| 8 | A survey onkey management mechanisms for distributed wireless sensor networks显示文摘 | Jr SIMPLíCIO M A BARRETO P S MARGI C B | 2010 | Computer Networks2010，54，15： | 1 |
| 9 | EVALUATION OF ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF PLANT EXTRACTS FROM SOUTHERN MINAS GERAIS CERRADO显示文摘 | Chavasco Juliana Moscardini Feliphe B?rbara Helena Muniz Prado E Cerdeira Claudio Daniel Leandro Fabr?cio Damasceno Coelho Luiz Felipe Leomil da Silva J?ferson Junior Chavasco Jorge Kleber Dias Amanda Latercia Tranches | 2014 | Revista do Instituto de Medicina Tropical de S?o Paulo2014，，1： | 1 |
| 10 | A note on Zadeh's extensions显示文摘 | HERIBERTO R F LAE'CIO C B RODNEY C B | 2001 | Fuzzy Sets and Systems2001，117，3： | 1 |
| 11 | Replacing egg yolk with soybean lecithin in the cryopreservation of stallion semen 显示文摘 | Papa F O Felr'cio G B Melo C M | 2011 | Anim Reprod Sci2011，129，12： | 1 |
| 12 | Mesophyll thickness and sclerophylly among Calotropis procera morphotypes reveal water-saved adaptation to environments显示文摘Calotropis procera(Aiton)Dryand(Apocynaceae)is a native species in tropical and subtropical Africa and Asia.However,due to its fast growing and drought-tolerant,it has become an invasive species when it was introduced into Central and South America,as well as the Caribbean Islands.Currently,C.procera displays a wide distribution in the world.Invasiveness is important,in particular,because many invasive species exert a high reproductive pressure on the invaded communities or are highly productive in their new distributed areas.It has been suggested that a very deep root system and a high capacity to reduce stomatal conductance during water shortage could allow this species to maintain the water status required for a normal function.However,the true mechanism behind the successful distribution of C.procera across wet and dry environments is still unknown.C.procera leaves were collected from 12 natural populations in Brazil,Colombia and Mexico,ranging from wet to dry environments during 2014–2015.Many traits of morphology and anatomy from these distinct morphotypes were evaluated.We found that C.procera leaves had a considerable capacity to adjust their morphological,anatomical and physiological traits to different environments.The magnitude of acclimation responses,i.e.,plasticity,had been hypothesized to reflect the specialized adaptation of plant species to a particular environment.However,allometric models for leaf area(LA)estimation cannot be grouped as a single model.Leaves are narrower and thicker with low amounts of air spaces inside the leaf parenchyma in wet environments,while they are broader and thinner with a small number of palisade cell layers in dry environments.Based on these,we argue that broader and thinner leaves of C.procera dissipate incident energy at the expense of a higher rate of transpiration to survive in environments in which water is the most limiting factor and to compete in favorable wet environments. | Marcelo F POMPELLI Keila R MENDES Marcio V RAMOS Jose N B SANTOS Diaa T A YOUSSEF Jaqueline D PEREIRA Laurício ENDRES Alfredo JARMA-OROZCO Rodolfo SOLANO-GOMES Betty JARMA-ARROYO Andre L J SILVA Marcos A SANTOS Werner C ANTUNES | 2019 | Journal of Arid Land2019，11，6： | 0 |
| 13 | Impact of rainfed and irrigated agriculture systems on soil carbon stock under different climate scenarios in the semi-arid region of Brazil显示文摘Understanding the dynamics of soil organic carbon(SOC) is of fundamental importance in land use and management, whether in the current researches or in future scenarios of agriculture systems considering climate change. In order to evaluate SOC stock of the three districts(Delmiro Gouveia, Pariconha, and Inhapi districts) in the semi-arid region of Brazil in rainfed and irrigated agriculture systems under different climate scenarios using the Century model, we obtained RCP4.5 and RCP8.5 climate scenarios derived from the Eta Regional Climate Model(Eta-Had GEM2-ES and Eta-MIROC5) from the National Institute for Space Research, and then input the data of bulk density, p H, soil texture, maximum temperature, minimum temperature, and rainfall into the soil and climate files of the Century model. The results of this study showed that the Eta-Had GEM2-ES model was effective in estimating air temperature in the future period. In rainfed agriculture system, SOC stock under the baseline scenario was lower than that under RCP4.5 and RCP8.5 climate scenarios, while in irrigated agriculture system, SOC stock in the almost all climate scenarios(RCP4.5 and RCP8.5) and models(Eta-Had GEM2-ES and Eta-MIROC5) will increase by 2100. The results of this study will help producers in the semi-arid region of Brazil adopt specific agriculture systems aimed at mitigating greenhouse gas emissions. | André L CARVALHO Renato A ARAúJO-NETO Guilherme B LYRA Carlos E P CERRI Stoécio M F MAIA | 2022 | Journal of Arid Land2022，14，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员