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| 1 | Outcome of patients with acute, necrotizing pancreatitis requiring drainage-does drainage size matter?显示文摘AIM:To assess the outcome of patients with acute necrotizing pancreatitis treated by percutaneous drainage with special focus on the influence of drainage size and number. METHODS:We performed a retrospective analysis of 80 patients with acute pancreatitis requiring percutaneous drainage therapy for infected necroses. Endpoints were mortality and length of hospital stay. The influence of drainage characteristics such as the median drainage size, the largest drainage size per patient and the total drainage plane per patient on patient outcome was evaluated. RESULTS:Total hospital survival was 66%. Thirty-four patients out of all 80 patients (43%) survived acute necrotizing pancreatitis with percutaneous drainage therapy only. Eighteen patients out of all 80 patients needed additional percutaneous necrosectomy (23%). Ten out of these patients required surgical necrosectomy in addition, 6 patients received open necrosectomy without prior percutaneous necrosectomy. Elective surgery was performed in 3 patients receiving cholecystectomy and one patient receiving resection of the parathyroid gland. The number of drainages ranged from one to fourteen per patient. The drainage diameter ranged from 8 French catheters to 24 French catheters. The median drainage size as well as the largest drainage size used per patient and the total drainage area used per patient did not show statistically significant influence on mortality. CONCLUSION:Percutaneous drainage therapy is an effective tool for treatment of necrotizing pancreatitis.Large bore drainages did not prove to be more effective in controlling the septic focus. | T Bruennler J Langgartner S Lang CE Wrede F Klebl S Zierhut S Siebig F Mandraka F Rockmann B Salzberger S Feuerbach J Schoelmerich OW Hamer | 2008 | World Journal of Gastroenterology2008，14，5： | 23 |
| 2 | The role of hypofractionation radiotherapy for diffuse intrinsic brainstem glioma in children: a pilot study显示文摘 | Janssens GO Gidding CE Van Lindert E J Oldenburger FR Erasmus CE Schouten-Meeteren A Y Kaanders JH | 2009 | 中国神经肿瘤杂志2009，7，3： | 8 |
| 3 | Low-grade gliomas:do changes in rCBV measurements at longitudinal perfusion-weighted MR imaging predict malignant transformation?显示文摘Radiology. 2008 Apr;247(1):170-8.PURPOSE: To prospectively perform longitudinal magnetic resonance (MR) perfusion imaging of conservatively treated low-gradegliomas to determine whether relative cerebral blood volume (rCBV) changes precede malignant transformation as defined | Danchaivijitr N Waldman AD Tozer DJ Benton CE Brasil Caseiras G Tofts PS Rees JH J?ger HR | 2008 | 中国神经肿瘤杂志2008，6，2： | 7 |
| 4 | 稳定性冠状动脉疾病患者的尿11-脱氢血栓素B_2与死亡率的关系显示文摘已有研究证明,应用阿司匹林抗血小板治疗可减少冠状动脉疾病(coronary artery disease,CAD)患者的不良预后。阿司匹林不可逆地抑制血小板环加氧酶1(cyclooxygenase-1,COX-1)并减弱血栓烷A2(thromboxane A2,TXA2)介导的血小板聚集, | 刘莉 叶鹏 McCullough PA Vasudevan A Sathyamoorthy M Schussler JM Velasco CE Lopez LR Swift C Peterson M Bennett-Firmin J Schiffmann R Bottiglieri T | 2017 | 中华高血压杂志2017，25，1： | 3 |
| 5 | 强化降压对高血压患者左心室肥厚的影响显示文摘目前尚不清楚超出推荐值的强化降压是否更能降低高血压患者的左心室肥厚(left ventricular hypertrophy,LVH)发生风险,以及LVH风险降低能否解释强化降压的益处。Soliman等纳入收缩压干预试验(systolic blood pressure intervention,SPRINT)中患有高血压但无糖尿病的8164例受试者(平均年龄67.9岁,女性35.3%,31.2%为非洲裔), | 刘莉 叶鹏 Soliman EZ Ambrosius WT Cushman WC Zhang ZM Bates JT Neyra JA Carson TY Tamariz L Ghazi L Cho ME Shapiro BP He J Fine LJ Lewis CE SPRINT Research Study Group | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 6 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 7 | Entrapment of migrating hippocampal neural cells in three-dimensional peptide nanofiber scaffold 显示文摘 | Semino CE Kasahara J Hayashi Y Zhang S | 2004 | Tissue Eng2004，10，： | 1 |
| 8 | The tyrosine pbosphatase PRL 1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis 显示文摘 | Wang J Kirby CE Herbst R | 2002 | J Biol Chem2002，277，46： | 1 |
| 9 | Cutaneous head anti neck squamous celt carcinoma metastatic to parotid and cervical lymph nodes 显示文摘 | Veness M J Porceddu S Pahne CE | 2007 | Head Neck2007，29，7： | 1 |
| 10 | P53 functions as a cell cycle control protein in osteosarcomas,显示文摘 | Kassel J Nelson CE | 1990 | Mol Cell Biol1990，10，11： | 1 |
| 11 | Expression of CXCR4 and CXCLl2(SDF-1)in human prostate cancem(PCa)in vivo显示文摘 | Sun YX Wang J Shelburne CE el al | 2003 | J Cell Biochem2003，89，3： | 1 |
| 12 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 13 | Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drng-resistant cancer显示文摘 | Btowder T Butterfield CE Kraling BM and Folkman J | 2000 | Cancer Res2000，60，7： | 1 |
| 14 | Amantadine for dyskinesia in Parkinson' s disease显示文摘 | Crosby N J Deane KH Clarke CE | 2003 | Cochrane Database Syst Rev2003，2，00： | 1 |
| 15 | Intrapartum cardiotocography and fetal pulse oximtery in assessing fetal hypoxia 显示文摘 | Leszczynska GB Poniedzialek CE Oleszczuk J | 2002 | Int J Gynacecol Obstet2002，76，1： | 1 |
| 16 | Vanishing lung syn- drome: upper lobe bullous pneumopathy显示文摘 | Roberts L Putman CE Chen J | 1987 | Rev Interam Radiol1987，12，： | 1 |
| 17 | Irradiation induces a biphasicexpression of pro-inflammatory cytokines in the lung 显示文摘 | Riibe CE Wilfert F Palm J | 2004 | Strahlenthe Onkol2004，180，7： | 1 |
| 18 | Mullisensory contribntions to low -level, imisensory' processing显示文摘 | Schrocder CE Foxe J | 2005 | Curr Opin Neurobiol2005，15，4： | 1 |
| 19 | Increased SNAIL ex- pression and low syndecan levels are associated with high Glea- son grade in prostate cancer显示文摘 | Pohlete CE Fulla J Gallardo M | 2014 | Int J Oncol2014，44，3： | 1 |
| 20 | miR-124 acts through CoREST to control onset of Sema3A sensitivity in navigat-ing retinal growth cones显示文摘 | Baudet ML Zivraj KH Abreu-Goodger C Muldal A Armisen J Blen-kiron C Goldstein LD Miska EA Holt CE | | 0，，： | 1 |
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