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| 1 | Clinical value of rapid urine trypsinogen-2 test strip, urinary trypsinogen activation peptide, and serum and urinary activation peptide of carboxypeptidase B in acute pancreatitis显示文摘AIM: To assess the usefulness of urinary trypsinogen-2 test strip, urinary trypsinogen activation peptide (TAP),and serum and urine concentrations of the activation peptide of carboxypeptidase B (CAPAP) in the diagnosisof acute pancreatitis.METHODS: Patients with acute abdominal pain and hospitalized within 24 h after the onset of symptoms were prospectively studied. Urinary trypsinogen-2 was considered positive when a clear blue line was observed (detection limit 50 μg/L). Urinary TAP was measured using a quantitative solid-phase ELISA, and serum and urinary CAPAP by a radioimmunoassay method.RESULTS: Acute abdominal pain was due to acute pancreatitis in 50 patients and turned out to be extrapancreatic in origin in 22 patients. Patients with acute pancreatitis showed significantly higher median levels of serum and urinary CAPAP levels, as well as amylase and lipase than extrapancreatic controls. Median TAP levels were similar in both groups. The urinary trypsinogen-2 test strip was positive in 68% of patients with acute pancreatitis and 13.6% in extrapancreatic controls (P<0.01). Urinary CAPAP was the most reliable test for the diagnosis of acute pancreatitis (sensitivity 66.7%, specificity 95.5%, positive and negative predictive values 96.6% and 56.7%, respectively), with a 14.6 positive likelihood ratio for a cut-off value of 2.32 nmol/L.CONCLUSION: In patients with acute abdominal pain,hospitalized within 24 h of symptom onset, CAPAP in serum and urine was a reliable diagnostic marker of acute pancreatitis. Urinary trypsinogen-2 test strip showed a clinical value similar to amylase and lipase.Urinary TAP was not a useful screening test for the diagnosis of acute pancreatitis. | Jesús Sáez Juan Martínez Celia Trigo José Sánchez-Payá Luis Compay Raquel Laveda Pilar Grió Cristina García Miguel Pérez-Mateo | 2005 | World Journal of Gastroenterology2005，11，46： | 21 |
| 2 | 基于岩土介质三维孔隙结构的两相流模型显示文摘地下储层中岩土介质一般具有较低的孔隙连通性,宏观流动模拟一般忽略微观尺度的孔隙连通性,通过渗透率、弯曲度等参数反映储层的整体特性。但岩土介质的多孔性及孔隙间复杂的连通性,使得宏观描述流体在岩土介质中流动不能反映其内在流动特征。孔隙结构模型的建立可以反映岩土介质中孔隙的几何形态及空间连通性,为解释流体在复杂多孔介质中的流动特性提供有效手段。通过考虑岩土介质孔隙尺寸分布、孔隙孔喉空间相关性、孔隙连通性等特征参数,建立了反映不同岩土介质连通性、各向异性特征的等效孔隙网络模型。等效孔隙网络模型通过水力特征参数等效的方式反映岩土介质三维微观孔隙结构,通过渗透率计算验证了模型的有效性。此外,基于建立的孔隙结构模型,开发了孔隙尺度动态两相流计算模型,模型可以反映孔隙内弯液面的动态运动过程,直观反映多孔介质中的优势渗流,可以为不同孔隙尺度岩土介质提供表观渗透率、击穿曲线、相对渗透率曲线等宏观计算参数。将孔隙尺度两相流模型应用于页岩气开采中水力阻滞特性研究,结果表明:页岩基质的残余饱和度约为30%,随着平均配位数的增加,残余饱和度显著降低。 | 张鹏伟 胡黎明 Jay N Meegoda Michael A Celia | 2020 | 岩土工程学报2020，42，1： | 10 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 5 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 6 | A functional relationship between capillary pressure,saturation,and interfacial areas as revealed by a pore-scale network model显示文摘 | Reeves P C Celia M A | 1996 | Water Resources Research1996，32，8： | 1 |
| 7 | Robotic-assisted rehabilitation of the upper limb after acute stroke显示文摘 | Masiero S Celia A Rosati G | 2007 | Arch Phys Med Rehabil2007，88，2： | 1 |
| 8 | Opportunities for low-cost CO2storage demonstration projects in China显示文摘 | Meng K C Williams R H Celia M A | 2007 | Energy Policy2007，35，4： | 1 |
| 9 | A functional relationship between capillary pressure, saturation, and interfacial area as revealed by a pore-scale network model显示文摘 | Reeves P C Celia M A | 1996 | Water Resources Research1996，32，8： | 1 |
| 10 | Non Sedgkm lymphoma of the ureter; a rare disease 显示文摘 | Celia A De Stefani S Bruschi M | 2004 | Arch Ital Urol Androl2004，76，4： | 1 |
| 11 | A human natural killer cell subset provides an innate source of IL-22 fur mucosal immunity 显示文摘 | Celia M Fuchs A Vermi W | 2009 | Nature2009，457，7230： | 1 |
| 12 | Parallel machine scheduling with job assignment restrietions显示文摘 | Celia A Glass Hans Kellerer | 2007 | Naval Research Logistics2007，54，10： | 1 |
| 13 | Enzymatic synthesis of S-adenosyl-L-methionine from L-methionine and ATP显示文摘 | Cross A Geresh S Celia W | 1983 | Appl Biochem Biotechnol1983，8，5： | 1 |
| 14 | Large scale nat- ural gradient tracer test in sand and gravel Cape Cod, Massachusetts 3: hydraulic conductivity variability and calculated macrodispersivities显示文摘 | HESS K M WOLF S H CELIA M A | 1992 | Water Resources Re- search1992，28，8： | 1 |
| 15 | Efficacy of treedefense physiology varies with bark beetle population density: abasis for positive feedback in eruptive species显示文摘 | CELIA K B BRIAN H A J RG B | 2011 | Canadian Journal of Forest Research2011，41，6： | 1 |
| 16 | Quality of life pre- dicts progression free survival in patients with metastatic renal cellcarcinoma treated with sunitinib versus interferon alfa 显示文摘 | Celia D Cappelleri JC Bushmakin A | 2009 | J On- col Pract2009，5，2： | 1 |
| 17 | A general mass-conservative numerical solution for the unsaturated flow equation显示文摘 | Celia M A Bouloutas E T Zarba R L | 1990 | Water Resour Res1990，26，： | 1 |
| 18 | Robotic -assisted rehabilitation of upper limp after acute stroke显示文摘 | Masiero S Celia A Rosati G | 2007 | Archives of Physical Medicine and re- habilitation2007，88，2： | 1 |
| 19 | Safe storage of CO2 in deep saline aquifers 显示文摘 | Bruant R G Guswa A J Celia M A | 2002 | Environmental Science & Technology2002，36，11： | 1 |
| 20 | Impaired flexible decision-making in Major Depressive Disorder 显示文摘 | Celia M Dymond S Cooper A | 2010 | J Affect Disord2010，124，12： | 1 |
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