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| 1 | Operative complications and economic outcomes of cholecystectomy for acute cholecystitis显示文摘BACKGROUND Recent management of acute cholecystitis favors same admission(SA)or emergent cholecystectomy based on overall shorter hospital stay and therefore cost savings.We adopted the practice of SA cholecystectomy for the treatment of acute cholecystitis at our tertiary care center and wanted to evaluate the economic benefit of this practice.We hypothesized that the existence of complications,particularly among patients with a higher degree of disease severity,during SA cholecystectomy could negate the cost savings.AIM To compare complication rates and hospital costs between SA vs delayed cholecystectomy among patients admitted emergently for acute cholecystitis.METHODS Under an IRB-approved protocol,complications and charges for were obtained for SA,later after conservative management(Delayed),or elective cholecystectomies over an 8.5-year period.Patients were identified using the acute care surgery registry and billing database.Data was retrieved via EMR,operative logs,and Revenue Cycle Operations.The severity of acute cholecystitis was graded according to the Tokyo Guidelines.TG18 categorizes acute cholecystitis by Grades 1,2,and 3 representing mild,moderate,and severe,respectively.Comparisons were analyzed withχ2,Fisher’s exact test,ANOVA,ttests,and logistic regression;significance was set at P<0.05.RESULTS Four hundred eighty-six(87.7%)underwent a SA while 68 patients(12.3%)received Delayed cholecystectomy.Complication rates were increased after SA compared to Delayed cholecystectomy(18.5%vs 4.4%,P=0.004).The complication rates of patients undergoing delayed cholecystectomy was similar to the rate for elective cholecystectomy(7.4%,P=0.35).Mortality rates were 0.6%vs 0%for SA vs Delayed.Patients with moderate disease(Tokyo 2)suffered more complications among SA while none who were delayed experienced a complication(16.1%vs 0.0%,P<0.001).Total hospital charges for SA cholecystectomy were increased compared to a Delayed approach($44500±$59000 vs$35300±$16700,P=0.019).The relative risk of developing a complication was 4.2x[95%confidence interval(CI):1.4-12.9]in the SA vs Delayed groups.Among eight patients(95%CI:5.0-12.3)with acute cholecystitis undergoing SA cholecystectomy,one patient will suffer a complication.CONCLUSION Patients with Tokyo Grade 2 acute cholecystitis had more complications and increased hospital charges when undergoing SA cholecystectomy.This data supports a selective approach to SA cholecystectomy for acute cholecystitis. | Christopher P Rice Krishnamurthy B Vaishnavi Celia Chao Daniel Jupiter August B Schaeffer Whitney R Jenson Lance W Griffin William J Mileski | 2019 | World Journal of Gastroenterology2019，25，48： | 8 |
| 2 | High performance liquid chromatographic separation of thirteen drugs collected in Chinese Pharmacopoeia 2010(Ch.P2010) on cellulose ramification chiral stationary phase显示文摘The enantiomers separation of thirteen drugs collected in Ch.P2010 was performed on chiral stationary phase of cellulose ramification (chiralpak OD and chiralpak OJ) by high performance liquid chromatographic (HPLC) methods, which included ibuprofen (C1), ketoprofen (C2), nitrendipine (C3), nimodipine (C4), felodipine (C5), omeprazole (C6), praziquantel (C7), propranolol hydrochloride (C8), atenolol (C9), sulpiride (C10), clenbuterol hydrochloride (C11), verapamil hydrochloride (C12), and chlorphenamine maleate (C13). The mobile phase consisted of isopropanol and n-hexane. The detection wavelength was set at 254 nm and the fiow rate was 0.7 mL/min. The enantiomers separation of these thirteen racemates on chiralpak OD column and chiralpak OJ column was studied, while the effects of proportion of organic additives, alcohol displacer and temperature on the separation were studied. And the mechanism of some of racemates was discussed. The results indicated that thirteen chiral drugs could be separated onchiral stationary phase of cellulose ramification in normal phase chromatographic system. The chromatographic retention and resolution of enantiomers could be adjusted by factors including column temperature and the concentration of alcohol displacer and organic alkaline modifier in mobile phase. It was shown that the resolution was improved with reducing concentration of alcohol displacer. When concentration of organic alkaline modifier was 0.2% (v/v), the resolution and the peak shape were fairly good. Most racemates mentioned above had better resolution at column temperature of 25 1C. When racemates were separated, the temperature should be kept so as to obtain stable separation results. | Ying Zhoua,b, Chao Maa, Yan Wanga, Qi-Ming Zhangb, Yi-Ying Zhanga, Jie Fua, Hong Gaoc, Li-Xun Zhaoc aState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China bNational Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China cInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China | 2012 | Journal of Pharmaceutical Analysis2012，2，1： | 4 |
| 3 | Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization显示文摘DNA 免疫是为高亲密关系的 monoclonal 抗体产生的一个有效方法。这里,我们对松香油绑定蛋白质 4 描述几高质量的 monoclonal 抗体(mAbs ) 的产生(RBP4 ) ,为肾反常和机能障碍的一个重要标记,与 DNA 的一个联合方法, priming 和蛋白质增加。产生的 mAbs 能与高敏感并且用这些 mAbs 绑在 RBP4,一块 immunocolloidal 金牌快测试长带被构造。长带能交上结果 < 5 min 并且与大约 1 ng/ml 的察觉限制是很敏感的。小规模的临床的测试表明这脱衣的结果根据在市场上当前可得到的一个标记酶的 immunosorbent 试金工具包的好。因而,它能为在诊所的更方便、更快的 RBP4 决心是有用的。 | Chao Bian Fang Zhang Feng Wang Zhiyang Ling Min Luo Hongqiang Wu Yizhuo Sun Junhui Li B ingnan Li Jingyan Zhu Linna Tang Yanyan Zhou Qunfang Shi Yongyong Ji Lin Tian Guomei Lin Yu Fan Niansong Wang Bing Sun | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 2 |
| 4 | Some solutions of the Timoshenko beam equations显示文摘 | Boley B A Chao C C | 1955 | Journal of Applied Mechanics1955，22，3： | 2 |
| 5 | External skeletal fixation of canine tibial osteotomies: Compression compared with no compression显示文摘 | Hart M B Wu J J Chao EYS | 1985 | J Bone Joint Surg(Am)1985，67，4： | 1 |
| 6 | Tourism, jobs, capital accumulation and the economy : A dynamic analysis 显示文摘 | Chao C Hazari B Laffargue P ( 2005 ) | 2005 | Department of Economics2005，，： | 1 |
| 7 | Ras p21 expression in the progression of breast cancer显示文摘 | FROMOWITZ F B VIOLA M V CHAO S | 1987 | Hum Pathol1987，18，： | 1 |
| 8 | A new heuristic for the multi-depot vehicle routing problem that improves upon best-known solutions显示文摘 | Chao M I Golden B L Wasil E A | 1993 | Am J Math Mgmt Sci1993，13，： | 1 |
| 9 | Cyclic strain-induced reactive oxygen species involved in ICAM-1 gene induction in endothelial cells显示文摘 | Cheng J J Wung B S Chao Y J | 1998 | Hypertention1998，，31： | 1 |
| 10 | Temporal variation of the Earth's Low-degree zonal gravitational field caused by atmospheric mass redistribution: 1980~1988显示文摘 | Chao B F Andrew Y Au | 1991 | Journal of Geophysical Research1991，96，4： | 1 |
| 11 | A per-flow based node architecture for integrated services packet networks显示文摘 | Wu Y T HOU B LI H J CHAO | 2001 | Telecommunication Systems (Baltzer)2001，17，12： | 1 |
| 12 | Chemical nature of in vivo DNA base damage in hydrogen peroxide-treated mammalian cells显示文摘 | Dizdaroglu M Nackerdien Z Chao B C | 1991 | Arch Biochem Biophys1991，285，： | 1 |
| 13 | Drinking and driving in Singapore,1987 to 1989显示文摘 | Chao T C Lo D S T Bloodworth B C | | 0，，03： | 1 |
| 14 | Coupling of biennial oceanic Rossby waves with the overlying atmosphere in the Pacific basin 显示文摘 | White W B Chao Y Chang K | 1998 | Journal of Physical Oceanography1998，28，12： | 1 |
| 15 | Floating bubble configurations显示文摘 | I MEDROW R A CHAO B T | 1971 | Physics of Fluids1971，14，3： | 1 |
| 16 | The Integrated Methodology of Rough Set Theory and Artificial Neural Network for Business Failure Prediction 显示文摘 | Ahn B S Chao S S | 2000 | Expert Systems with Application2000，18，2： | 1 |
| 17 | Rasp21 expression in the progression of breast cancer 显示文摘 | FROMOWETZ F B VOILA M V CHAO S | 1987 | Human Patuol1987，18，： | 1 |
| 18 | Microcharacterization of arsenic-and selenium-bearing pyrite in Upper Freeport coal, Indiana County, Pennsylvania显示文摘 | Minkin J A Finkelman R B Thompson C L Chao E C T Ruppert L F Blank H Cecil C B | 1984 | Scanning Electron Microscopy1984，4，： | 1 |
| 19 | Tissue kallikrein in cardiovascular,cerebrovascular and renal diseases and skin wound healing显示文摘 | Chao J Shen B Gao L | 2010 | Biol Chem2010，391，4： | 1 |
| 20 | Preparation and characterization of inclusion complexes of pefloxacinmesy late with three kinds of cyclodextrins显示文摘 | Chao J B Tong H B Liu D S | 2006 | Spectrochimica Acta Part A2006，64，1： | 1 |
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