|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | 高速电镀钯-镍合金工艺显示文摘由于金用作电子连接接触表面镀层,成本高,电镀钯-镍合金已成为最具吸引力的接触材料的替代品。然而,传统氨系电镀钯-镍工艺和新的无氨电镀钯-镍工艺有许多环保特征未能达到最佳。与早期电镀钯-镍合金相比,低氨高速电镀钯-镍合金工艺具有技术性能卓越,物料消耗降低和环境状况改善等优势。 | CLAUSS M GUEBEY J SCHWAGER F | 2009 | 电镀与环保2009，29，6： | 3 |
| 3 | Stiff macromolecules with aliphatic side-chains-side-chian mobility, conformation, and organization from 2D solid-state NMR spectroscopy显示文摘 | Clauss J Schmidtrohr K Adam A | 1992 | Macromolecules1992，25，20： | 1 |
| 4 | Bicontinous structurezones in microemulsions显示文摘 | Clausse M Peyrelasse J Heil J | 1981 | Nature1981，293，43： | 1 |
| 5 | A population of mu- hipotent CD34 -positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendotheli,l location, and stabilize endothelial networks 显示文摘 | Traktuev DO Merfeld - Clauss S Li J | 2008 | Circ Res2008，102，1： | 1 |
| 6 | Custom cerium oxide nanoparticles protect against a rice radical mediated autoimmune degenerative disease in the brain 显示文摘 | Heckman K L DeCoteau W Estevez A Reed K J Costanzo W Sanford D Leiter J C Clauss J Knapp K Gomez C Mullen P Rathbun E Prime K Marini J Patchefsky J Patchefsky A S Hailstone R K Erli- chman J S | 2013 | ACS Nano2013，7，10： | 1 |
| 7 | A population of multipotent CD34 - positive adipose atromal ceils share pericyte and mesenchymal surface markers, reside in a periendothelial location, and sta- bilize endothelial networks 显示文摘 | Traktuev DO Merfeld - Clauss S Li J | 2008 | Circ Res2008，102，1： | 1 |
| 8 | Study of mass transfer in oil-water-oil multiple emulsions by differential scanning calorimetry显示文摘 | Avendano G J R Grossiord J L Clausse D | 2005 | Journal of Colloid and Interface Science2005，290，2： | 1 |
| 9 | Correlation of structure,mobility,and morphological information in heterogeneous polymer materials by two-dimensional wideline-separation NMR spectroscopy\显示文摘 | Schmidt-Rohr K Clauss J Spiess H W | 1992 | Macromolecules1992，25，12： | 1 |
| 10 | Natural Variation in MAM Within and Between Populations of Ar abidopsis @rata Determines Glucosinolate Phenotype 显示文摘 | HEIDEL A J CLAUSS M J KROYMANN J | 2006 | Genetics2006，173，3： | 1 |
| 11 | Study of mass transfer in oil-water-oil multiple emulsions by differ- ential scanning calorimetry显示文摘 | Avendano-Gomez J R Grossiord J L Clausse D | 2005 | Colloid and Interface Sci-ence2005，290，2： | 1 |
| 12 | The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core显示文摘 | Clauss IM Chu M Zhao J | 1996 | Nucl Acids Res1996，24，： | 1 |
| 13 | Determination of domain sizes in heterogeneous polymers by solid-state NMR显示文摘 | Clauss J Schmidt-Rohr K Spiess H W | 1993 | Acta Polym1993，44，1： | 1 |
| 14 | Poorly known relatives of Arabidopsis thaliana显示文摘 | Clauss M J Koch M A | 2006 | Trends in Plant Science2006，11，9： | 1 |
| 15 | Microstructure and high-temperature mechanical behavior of alumina/alumina-yttria-stabilized tetragonal zirconia multilayer composites显示文摘 | MANUEL J M CLAUSS C | 1997 | Journal of the American Ceramic Society1997，80，8： | 1 |
| 16 | Self-optimizing and adaptive digital signal processor based algorithms in scanning tunneling microscopy显示文摘 | Scheuring J Clauss W Kern D P | 1998 | Review of Scientific Instruments1998，69，： | 1 |
| 17 | Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes 显示文摘 | Shen H Clauss M Ryan J | 1993 | Blood1993，81，10： | 1 |
| 18 | Use of artificially applied n-alkanes as markers for the estimation of digestibility, food selection and intake in pigeons(Columba livia)显示文摘 | Hatt J M Mayes R W Clauss M | 2001 | Animal Feed Science and Technology2001，94，12： | 1 |
| 19 | Correlation of structure, mobility, and morphological information in heterogeneous polymer materials by two-dimensional wideline-separation NMR spectroscopy显示文摘 | Schmidt-Rohr K Clauss J Spiess H W | 1992 | Macromole cules1992，25，12： | 1 |
| 20 | Use of artificially applied n-alkanes as markers for the estimation of digestibility, food selection and intake in pigeons (Columba livia) 显示文摘 | Hatt J M Mayes R W Clauss M | 2001 | Animal Feed Science and Technology2001，94，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员