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| 1 | Chemical and pharmacological evaluation of Hypericum perforation extracts显示文摘KEY WORDS Hypericum perforation; High pressure liquid chromatography; serotonin uptake inhibitors; tree radicals; antioxidants; hyperforin; hypericin; quercetin; rutinABSTRACTAIM: To determine the concentrations of chemical characteristic to extracts of leaves and flowers of Hypericum perforatnm (St John’s wort) in a number of selected samples and, following chemical characterization, to investigate the effects of these extracts on several pharmacological properties including effects of the extracts on inhibition of 5-hydroxytryptamine (5-HT) uptake and on an-tioxidant properties. METHODS: The samples were analyzed for the presence of characteristic chemicals by high performance liquid chromatography (HPLC) directly coupled to ultraviolet wavelength absorbance and positive or negative mode electrospray mass spectrometric detection. The effects of extracts on 5-HT uptake were determined by quantifying 3H-5-HT incorporation into rat hip-pocampal prisms. Estimates of effects of extracts on free radical | B Duff SLOLEY Liana J URICHUK LING Lei GU Lie-Dong Ronald T COUTTS Peter K T PANG Jacqueline J SHAN | 2000 | Acta Pharmacologica Sinica2000，21，12： | 2 |
| 2 | Microbiological End-Point Determination of Antibiotics显示文摘 | Coutts J T Smith J S | 1998 | Microbial Ecol Health Dis1998，10，： | 1 |
| 3 | Vascular rings-presentation, investigation and outcome 显示文摘 | Turner A Gavel G Coutts J | 2005 | Eur J Pediatr2005，164，： | 1 |
| 4 | Characteristics influencing the variability of urban CO2 fluxes in melbourne,Australia显示文摘 | COUTTS A M BERINGER J TAPPER N J | | 0，，01： | 1 |
| 5 | Triaging Transient Ischemie Attack and Minor Stroke Patients Using Acute Magnetic Resonance Imaging 显示文摘 | Coutts SB Simon J E Eliasziw M | 2005 | Ann Neurol (S0364-- 5134)2005，57，： | 1 |
| 6 | Bacteriology, in- flammation, and healing: a study of nanocrystalline silver dress- ings in chronic venous leg ulcers 显示文摘 | Sibbald RG Contreras-Ruiz J Coutts P | 2007 | Adv Skin Wound Care2007，20，10： | 1 |
| 7 | A one-step homogeneous immu-noassay for cancer biomarker detection using gold nanoparticle probes coupled with dynamic light scattering显示文摘 | Dai Q Austin L Coutts J | | 0，，09： | 1 |
| 8 | Bacteriolo gy,inflammation, and healing: a study of nanocrystailine Silver dressings in chronic venous leg ulcers显示文摘 | Sibbald RG Contreras-Ruiz J Coutts P | 2007 | Adv Skin Wound Care2007，20，10： | 1 |
| 9 | Polymorphic cytochromes P450 and drugs used in psychiatry显示文摘 | Coutts R T Urichuk L J | 1999 | Cell Mol Neu- robiol1999，19，3： | 1 |
| 10 | Bacteriology, inflam-mation, and healing: a study of nanocrystalline silver dressings inchronic venous leg ulcers 显示文摘 | Sibbald RG Contreras-Ruiz J Coutts P | 2007 | Adv Shin Wound Care2007，20，10： | 1 |
| 11 | Effect of bifidobacterium- longumand inulin on gut bacterlalmetabolism and carcinogen-in- duced aberrant crypt fociin rats 显示文摘 | Rowland I R Rumney C J Coutts J T | 1998 | Carcinogenesis1998，19，281： | 1 |
| 12 | Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and car cinogen-induced aberrant-crypt foci in rats显示文摘 | ROWLAND I R RUMNEY C J COUTTS J T | 1998 | Carcinogenesis1998，19，2： | 1 |
| 13 | Triaging transient ischemic attack and minor stroke patients using a- cute magnetic resonance imaging显示文摘 | Coutts S B Simon J E Eliasziw M | 2005 | Annals of neurology2005，57，6： | 1 |
| 14 | Monitoring changes in performance, physiology, biochemisty, and psychology during overreaching and recovery in triathletes显示文摘 | Coutts A J Wallace L K Slattery K | 2007 | Int J Sports Med2007，28，3： | 1 |
| 15 | Hepatic phosphorus-31 magnetic resonance spectroscopy in primary biliary cirrhosis and its relation to prognostic models 显示文摘 | Jalan R Sargentoni J Coutts GA | 1996 | Gut1996，39，1： | 1 |
| 16 | Characterization of IGF21 receptors in the porcine small intestine during postnatal development 显示文摘 | Morgan C J Coutts A G P McFadyen M C | 1996 | The Journal of Nutritional Biochemistry1996，7，6： | 1 |
| 17 | Characterization of IGF'21 receptors in the porcine small intestine during postnatal development 显示文摘 | Morgan C J Coutts A G P McFadyen M C | 1996 | The Journal of Nutritional Biochemistry1996，7，6： | 1 |
| 18 | A review of progress in thermophotovohaic generation of electricity 显示文摘 | COUTTS T J | 1999 | Renewable and Sustainable Energy Reviews1999，36，3： | 1 |
| 19 | Systematic review of associations between the presence of acute ischemic lesions on diffusion weighted imaging and clinical predictors of early stroke risk after tran- sient ischemic attack显示文摘 | Redgrave J N Coutts SB Schulz UG | 2007 | Stroke2007，38，5： | 1 |
| 20 | Flexible bronchoscopy in pediatric inten-sive care显示文摘 | Davidson MG Coutts J Bell G | 2008 | Pediatr Pulmonol2008，43，12： | 1 |
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