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| 1 | Ethanol injection is highly effective for hepatocellular carcinoma smaller than 2cm显示文摘AIM:To analyze the long-term prognosis in a cohort of western cirrhotic patients with single hepatocellular carcinoma treated with ethanol injection.METHODS:One-hundred forty-eight patients with solitary hepatocellular carcinoma were enrolled.The tumor diameter was lower than 2 cm in 47 patients but larger in the remaining 101 patients.The impact of some pretreatment clinical and laboratory parameters and of tumor recurrence on patients' survival was assessed.RESULTS:Among the pre-treatment parameters,only a tumor diameter of less than 2 cm was an independent prognostic factor of survival.The occurrence of new nodules in other liver segments and the neoplastic portal invasion were linked to a poorer prognosis at univariate analysis.Patients with a single hepatocellular carcinoma smaller than 2 cm showed a better 5-year cumulativesurvival(73.0% vs 47.9%)(P = 0.009),3-year local recurrence rate(29.1% vs 51.5%)(P = 0.011),and 5-year distant intrahepatic recurrence rate(52.9% vs 62.8%)(P = 0.054) compared to patients with a larger tumor.CONCLUSION:The 5-year survival rate of patients with single hepatocellular carcinoma < 2 cm undergoing ethanol injection is excellent and comparable to that achieved using radiofrequency ablation. | Maurizio Pompili Erica Nicolardi Valeria Abbate Luca Miele Laura Riccardi Marcello Covino Nicoletta De Matthaeis Antonio Grieco Raffaele Landolfi Gian Ludovico Rapaccini | 2011 | World Journal of Gastroenterology2011，17，26： | 6 |
| 2 | Heart rate variability: a new tool to predict complications in adult cardiac surgery显示文摘心率可变性(HRV ) 指在连续心跳之间的变化,它取决于自治神经系统的同情、副交感的分支的连续调整。HRV 被显示了作为在心肌的梗塞和糖尿病的神经病的早警告症状以后的风险的一个预言者有效,并且在心病学,背景是认出是为在医院承认以后并且在分泌物以后的风险层化的一个有用工具的现在。最近的证据建议 HRV 分析可能甚至在经历心脏的外科,和现在的评论的病人预言复杂并发症在当前的临床的实践为 HRV 使用在成年心脏的外科和观点总结 HRV 分析的重要性。尽管未来在 HRV 能在成年心脏的外科被包括进每日的临床的实践以前,更大的研究被保证, HRV 是可能在早手术后的阶段并且在医院停留期间检测自治不稳定性的一个新奇工具,因此预言或迅速诊断许多手术后的复杂并发症。 | Antonio Nenna Mario Lusini Cristiano Spadaccio Francesco Nappi Salvatore Matteo Greco Raffaele Barbato Elvio Covino Massimo Chello | 2017 | Journal of Geriatric Cardiology2017，14，11： | 4 |
| 3 | Effect of different probiotic preparations on anti- Helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study显示文摘 | Filippo Cremonini Simona Di Caro Marcello Covino Alessandro Armuzzi Maurizio Gabrielli Luca Santarelli Enrico C Nista Giovanni Cammarota Giovanni Gasbarrini Antonio Gasbarrini | 2002 | The American Journal of Gastroenterology2002，，11： | 2 |
| 4 | Prevalence and natural history of hepatitis B and C infections in a large population of IBD patients treated with anti-tumor necrosis factor-α agents显示文摘 | Alfredo Papa Carla Felice Manuela Marzo Gianluca Andrisani Alessandro Armuzzi Marcello Covino Giammarco Mocci Daniela Pugliese Italo De Vitis Antonio Gasbarrini Gian Lodovico Rapaccini Luisa Guidi | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 5 | Animal modeling in bone research—Should we follow the White Rabbit?显示文摘Animal models are live subjects applied to translational research.They provide insights into human diseases and enhance biomedical knowledge.Livestock development has favored the pace of human social development over millennia.Today's society is more aware of animal welfare than past generations.The general public has marked objections to animal research and many species are falling into disuse.The search for an ideal methodology to replace animal use is on,but animal modeling still holds great importance to human health.Bone research,in particular,has unmet requirements that in vitro technologies cannot fully address.Standardizing novel models remains necessary and rabbits are gaining in popularity as potential bone models.Our aim here is to provide a broad overview of animal modeling and its ethical implications,followed by a narrower focus on bone research and the role rabbits are playing in the current scenario. | Aline Schafrum Macedo Caroline Cezaretti Feitosa Fernando Yoiti Kitamura Kawamoto Paulo Vinicius Tertuliano Marinho Isis dos Santos Dal‐Bo Bianca Fiuza Monteiro Leonardo Prado Thales Bregadioli Gabriel Antonio Covino Diamante Cassio Ricardo Auada Ferrigno | 2019 | Animal Models and Experimental Medicine2019，2，3： | 2 |
| 6 | Contrast-enhanced gray- scale harmonic ultrasound in the efficacy assessment of ablation treatments for hepatocellular carcinoma 显示文摘 | Pompili M Rieeardi L Covino M | 2005 | Liver Int2005，25，5： | 1 |
| 7 | Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study 显示文摘 | Cremonini F Di Caro S Covino M | 2002 | Am J Gastroentero12002，97，11： | 1 |
| 8 | The accuracy of measurements of three-dimensional computed tomography reconstructions显示文摘 | Mitnick RJ Shprintzen RJ | 1996 | J Oral Maxillofac Surg1996，54，： | 1 |
| 9 | Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine,bupivacaine and lidocaine in the consious dog显示文摘 | FELDMAN H S ARTHUR G R COVINO B G | 1989 | Anesth Analg1989，69，： | 1 |
| 10 | Corrosion prevention and remediation strategies for reinforced concrete coastal bridges显示文摘 | CRAMER S D COVINO JR B S BULLARD S J | 2002 | Cement & Concrete Composites2002，，24： | 1 |
| 11 | Corrosion Prevention and Remediation Strategies for Reinforced Concrete Coastal Bridges 显示文摘 | S D Cramera B S Covino Jr S J Bullard R Holcombe | 2002 | Cement and Concrete Composites2002，24，1： | 1 |
| 12 | Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study显示文摘 | CREMONINI F di CARO S COVINO M | 2002 | Am J Gastroenterol2002，97，11： | 1 |
| 13 | Corrosion prevention and remediation strategies for reinforced concrete coastal bridges 显示文摘 | Cramer S D Covino Jr B S Bullard S J | 2002 | Cement and Concrete Composites2002，24，1： | 1 |
| 14 | Effect of differentprobiotic preparations on anti-helicobacter pylori therapy-related sideeffects:a parallel group,triple blind,placebo-controlled study显示文摘 | CREMONINI F DI CARO S COVINO M | 2002 | AmJ Gastroenterol2002，97，11： | 1 |
| 15 | Current assessment methodology for electrostatic discharge hazards of energetic materials显示文摘 | Covino J Hudson F E | 1991 | Journal of Propulsion and Power1991，7，6： | 1 |
| 16 | Effect of baricity on spinal anesthesia with amethocaine显示文摘 | Bromage PR Wildsmith JAW Covino BG | 1980 | Br J Anesth1980，52，12： | 1 |
| 17 | Effect of different probiotic preparations on anti-Helicobacter pylori therapy-related side effects:a parallel group, triple blind, placebo-controlled study 显示文摘 | Cremonini F Di Caro S Covino M | 2002 | Am J Gastroenterol2002，97，： | 1 |
| 18 | Comparative pharmacokinetics of bupivacaine and ropivacaine, a new amide local anesthetic 显示文摘 | ARTHUR G R FELDMAN H S COVINO B G | 1988 | Anesth Analg1988，67，11： | 1 |
| 19 | Utility of alphafetoprotein (AFP) in the screening of patients with virus-related chronic liver disease:does different viral etiology influence AFP levels in HCC? A study in 350 western patients显示文摘 | Cedrone A Covino M Caturelli E | 2000 | Hepatogastroenterology2000，47，： | 1 |
| 20 | Can chronic gastritis cause an increase in fecal calprotectin concentrations?显示文摘AIM:To evaluate fecal calprotectin concentrations(FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score.METHODS:FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers.Histological grading of gastritis was performed according to the updated Sydney gastritis classification.Patients were subdivided into 2 groups according to the presence/absence of an active gastritis.Patients with chronic active gastritis were divided into 3 subgroups on the basis of the activity score(mild,moderate,marked).FFCs in relation to Helicobacter pylori(H.pylori) infection and proton pump inhibitor(PPI) use were also evaluated.RESULTS:FCCs in patients with chronic active gastritis were not significantly different to FCCs either in subjects with non active gastritis or in healthy controls.Among patients with chronic active gastritis(even marked),FCCs did not significantly differ according to activity score.No significant differences in FCCs were found when considering H.pylori,as well as when considering PPI chronic use.CONCLUSION:FCCs were not significantly increased in subjects with chronic gastritis,even in those patients with a marked neutrophil infiltration. | Massimo Montalto Antonella Gallo Gianluca Ianiro Luca Santoro Ferruccio D Onofrio Riccardo Ricci Giovanni Cammarota Marcello Covino Monica Vastola Antonio Gasbarrini Giovanni Gasbarrini Ricca rdo Ricci | 2010 | World Journal of Gastroenterology2010，16，27： | 1 |
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