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| 1 | Repurposing metformin for the treatment of gastrointestinal cancer显示文摘Diabetes mellitus type 2 and cancer share many risk factors.The pleiotropic insulin-dependent and insulin-independent effects of metformin might inhibit pathways that are frequently amplified in neoplastic tissue.Particularly,modulation of inflammation,metabolism,and cell cycle arrest are potential therapeutic cancer targets utilized by metformin to boost the anti-cancer effects of chemotherapy.Studies in vitro and in vivo models have demonstrated the potential of metformin as a chemo-and radiosensitizer,besides its chemopreventive and direct therapeutic activity in digestive system(DS)tumors.Hence,these aspects have been considered in many cancer clinical trials.Case-control and cohort studies and associated meta-analyses have evaluated DS cancer risk and metformin usage,especially in colorectal cancer,pancreatic cancer,and hepatocellular carcinoma.Most clinical studies have demonstrated the protective role of metformin in the risk for DS cancers and survival rates.On the other hand,the ability of metformin to enhance the actions of chemotherapy for gastric and biliary cancers is yet to be investigated.This article reviews the current findings on the anti-cancer mechanisms of metformin and its apparatus from pre-clinical and ongoing studies in DS malignancies. | Ademar Dantas Cunha Júnior Arinilda Campos Bragagnoli Felipe Osório Costa JoséBarreto Campello Carvalheira | 2021 | World Journal of Gastroenterology2021，27，17： | 5 |
| 2 | The nonsubsampled Contourlet transform: theory, design, and applications 显示文摘 | Cunha A L Zhou J Do M N | 2006 | IEEE Transactions on Image Process2006，15，10： | 1 |
| 3 | Characterization of Pore Systems in Seal Rocks Using Nitrogen Gas Adsorption Combined with Mercury Injection Capillary Pressure Techniques 显示文摘 | Schmitt M Fernandes C P da Cunha Neto J A B | 2013 | Marine and Petroleum Geology2013，39，1： | 1 |
| 4 | Selection of models of lactation curves to use in milk production simulation systems显示文摘 | Cunha D N F V Pereira J C Campos O F | 2010 | Rev Bras Zootecn2010，39，4： | 1 |
| 5 | Preparation, characterization and application of Pt-Ru-Sn/C trimetallic electrocatalysts for ethanol oxidation in direct fuel cell 显示文摘 | Cunha E Ribeiro J Kokoh K | 2011 | Int J Hydrogen Energy2011，36，11： | 1 |
| 6 | 3D reconstitution of porous media from image processing data using a mulfiscale percolation system 显示文摘 | DAIAN J F FERNANDES C P PHILIPPI P C BELLINI DA CUNHA NETO J A | 2004 | Journal of Petroleum Science and Engineering2004，42，1： | 1 |
| 7 | The NonSubsampled Contourlet Transform: Theory, design, and applications 显示文摘 | Cunha A L Zhou J and Do M N | 2006 | IEEE Transactions on Image Processing2006，15，10： | 1 |
| 8 | Severe and persistent hypoglycemia due to gatifloxacin interaction with oral hypoglycemic agents显示文摘 | Dorsainvil P A Cunha B A | 2002 | Am J Med2002，113，： | 1 |
| 9 | Nitric oxide is involved in control of Trypansoma cruzi-induced parasitemia and directly kills the parasite in vivo显示文摘 | Glaucia N R V Cunha J S | 1994 | Infection and Immunity1994，62，11： | 1 |
| 10 | Insulin in W/O/W multiple emulsions:biological activity after oral administration in normal and diabetic rats显示文摘 | Cunha A S Grossiord J L Puisieux F | 1997 | J Microencapsulation1997，14，3： | 1 |
| 11 | Insulin in W/O/W multiple emulsions: biological activity after administration in normal and diabetic rats 显示文摘 | Silva Cunha A Grossiord J L Puiseux F | 1997 | J Mierueneapsulatiun1997，14，： | 1 |
| 12 | The nonsubsampledcontourlet transform : theory,design,and applica-tions 显示文摘 | Cunha A L Zhou J Do M N | 2006 | IEEE Transactions on Image Process-ing2006，15，10： | 1 |
| 13 | Thoracoscopic ver- sus thoracotomy approaches to lobectomy: differential impairment of cellular immunity 显示文摘 | Whitson BA D'Cunha J Andrade RS | 2008 | The Annals of thoracic surgery2008，86，6： | 1 |
| 14 | Methane decomposition on La2O3-promoted Raneytype Fe catalyst显示文摘 | CUNHA A F MAHATA N ORFAO J J | 2009 | Energy Fuel2009，23，8： | 1 |
| 15 | Measuring self- efficacy to deal with infertility: psychometric properties and confirmatory factor analysis of the Portuguese ver- sion of the infertility self-efficacy scale显示文摘 | Galhardo A Cunha M Pinto-Gouveia J | 2013 | Res Nurs Health2013，36，1： | 1 |
| 16 | Altering the time of the second gonadotropin-releasing hormone injection and artifi- cial insemination (AI)during Ovsyneh affects pregnancies per AI in lactating dairy cows显示文摘 | Brusveen D J Cunha A P Silva C D | 2008 | J Dairy Sci2008，91，3： | 1 |
| 17 | The nonsubsampled contourlet transform:Theory,design and applications显示文摘 | CUNHA A L da ZHOU J DO M N | 2006 | IEEE Trans Image Process2006，15，10： | 1 |
| 18 | Output-feedback model-reference sliding mode control of uncertain multivariable systems显示文摘 | CUNHA J P V S LIU H COSTA R R | 2003 | IEEE Transactions on Automatic Control2003，48，12： | 1 |
| 19 | The nonsubsampled contourlet transform:Theory,design,and applications显示文摘 | CUNHA A L ZHOU J DO M N | 2006 | IEEE Transactions on Image Processing2006，15，30： | 1 |
| 20 | Bioprocess iterative batch-to-batch optimization based on hybrid parametric/nonparametric models显示文摘 | Teixeira A P Clemente J J Cunha A E | 2006 | Biotechnology Progress2006，22，1： | 1 |
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