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| 1 | Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin显示文摘AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional status.METHODS Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman's correlation and linear regression.RESULTS One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of H.pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cag A-positive patients. | Paula Mantero Gonzalo Sebastián Matus Rodolfo Ernesto Corti Ana María Cabanne Gerardo Gabriel Zerbetto de Palma Liliana Marchesi Olid María Marta Piskorz Marcela Beatriz Zubillaga Mariana Andrea Janjetic Cinthia Gabriela Goldman | 2018 | World Journal of Gastroenterology2018，24，3： | 8 |
| 2 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 3 | Mutations in the IκBα gene in Hodgkins disease suggest a tunmor suppressor role for IκBα显示文摘 | Cabannes E Khan G Aillet F | 1999 | Oncogene1999，18，20： | 1 |
| 4 | Oils for weed control:uses and mode ofaction 显示文摘 | Gauvrit C Cabanne F | 1993 | Pesticide Science1993，37，： | 1 |
| 5 | Genetic environment and expression of the extended-spectrum beta-lactamase blaPER- 1 gene in gram-negative bacteria 显示文摘 | Poirel L Cabanne L Vahaboglu H | 2005 | Antimicrob Agents Chemother2005，49，5： | 1 |
| 6 | Purification and on-column refolding of EGFP overexpressed as inclusion bodies in Escherichia coli with expanded bed anion exchange chromatography显示文摘 | CABANNE C NOUBHANI A M HOCQUELLET A | | 0，，： | 1 |
| 7 | Penicillin acylase purification with the aid of hydrophobic charge induction chromatography显示文摘 | Coulon D Cabanne C Fitton V | 2004 | Journal of Chromatography B2004，808，1： | 1 |
| 8 | Effect of the cytochrome P450 inactivator 1-aminobenzotriazole on the metabolism of chlortoluron and isoproturon in wheat 显示文摘 | Cabanne F Hubby D Gaillardon P | 1987 | Pestic Biochem Physiol1987，28，： | 1 |
| 9 | Genetic environment and expression of the extended-spectrum beta lactamase bla- PER-1 gene in Gram-negative bacteria显示文摘 | Poirel L Cabanne L Vahaboglu H | 2005 | Antimicrob Agents Chemother2005，49，5： | 1 |
| 10 | Oils for weed control:uses and mode of action显示文摘 | Gauvrit C Cabanne F | 1993 | Pesticide Science1993，37，2： | 1 |
| 11 | Behavior of Alkyl Oleates Following Foliar Application in Relation to Their Influence on the Penetration of Phenmedipham and Quizalofop-P-ethyl显示文摘 | MERCIER L SERRE I CABANNE F | 1997 | Weed Research1997，37，： | 1 |
| 12 | Genetic environment and expression of the extended-speetrurn beta-lactamase blapER-1 gene in gram-negative bacteria显示文摘 | Poirel L Cabanne L Vahaboglu H | 2005 | Antimierob Agents Chemother2005，49，5： | 1 |
| 13 | Effect of the cytochrome P450 inactivator 1-aminobenzotriazole on the metabolism of chlortoluron and isoproturon in wheat显示文摘 | Cabanne F Hudy D Gaillardon P | 1987 | Pestic Biochem Physid1987，28，： | 1 |
| 14 | Genetic environment and expression of the extended-spectrum beta-lactamase blaPER-1 gene in Gram-negative bacteria显示文摘 | Poirel L Cabanne L Vahaboglu H | 2005 | Antimicrob Agents Chemother2005，49，17： | 1 |
| 15 | ClassⅡtransposon-bornestructure harboring metallo-β-lactamase gene blaVIM-2 inPseudomonas putida显示文摘 | Poirel L Cabanne L Collet L | 2006 | Antimicrob Agents Chemother2006，50，8： | 1 |
| 16 | Oils for weed control: uses and mode of action显示文摘 | Gauvrit C Cabanne F | 1993 | Pesticide Science1993，37，： | 1 |
| 17 | Oils for weed control:uses and mode of action显示文摘 | Gauvrit C Cabanne F | 1993 | Pestic Sci1993，37，： | 1 |
| 18 | Genetic environment and expression of the extended-spectrum P-lactamase blaPER-1 gene in gram-negative bacteria显示文摘 | Poirel L Cabanne L Vahaboglu H | 2005 | Antimicrob Agents Chemother2005，49，5： | 1 |
| 19 | Behavior of alkyl oleates following foliar application in relation to their influence on the penetration of phenmedipha and quizalofop-P-ethy 显示文摘 | Mercier L Serre I Cabanne F | 1997 | Weed Research1997，37，： | 1 |
| 20 | Genetic environment and expression of the extended-spectrum beta-lactamase blaPER-1 gene in Gram-negative bacteria显示文摘 | Poirel L Cabanne L Vahaboglu H | 2005 | Antimicrob Agents Chemother2005，49，5： | 1 |
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