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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Advances in the management of cholangiocarcinoma显示文摘Cholangiocarcinoma(CCA)is a primary malignancy of the bile ducts with three anatomically and molecularly distinct entities:Intrahepatic CCA(iCCA),perihilar CCA(pCCA),and distal CCA.As a result of phenotypic and anatomic differences they differ significantly with respect to management.For each type of CCA there have been significant changes in management over the last several years which will be discussed in this review.Although resection remains the standard of care for all types of CCA,liver transplantation has been established as curative treatment for selected patients with pCCA and is being evaluated for iCCA with early success.With respect to systemic therapy capecitabine is now first line adjuvant therapy for all biliary tract malignancies after curative intent resection.Progress in exploiting the pathologic mutations and molecular abnormalities has also yielded regulatory approval of targeted therapy for CCA in patients with acquired alterations in the fibroblast growth factor receptor.There is also increased consensus in managing malignant biliary obstruction associated with CCA where pre-operative biliary stenting is not beneficial while self-expanding metal stents have been shown to be superior to plastic stents in patients who are not surgical candidates. | Andreas G Zori Dennis Yang Peter V Draganov Roniel Cabrera | 2021 | World Journal of Hepatology2021，13，9： | 2 |
| 3 | Determinants of technical efficiency among dairy farms in Wisconsin显示文摘 | Cabrera V E Soils D Corral J | 2010 | Journal of Dairy Science2010，93，1： | 1 |
| 4 | Anatomic relations between the esophagus and left atrium and relevance for ablation of atrial fibrillation显示文摘 | SaNCHEZ-QUINTANA D CABRERA J A CLI MENT V | 2005 | Circulation2005，112，： | 1 |
| 5 | Apoptosis as a possible mechanism of infertility in Echinococcus granulosus cyst 显示文摘 | Paredes R Jimenez V Cabrera G | 2007 | Cell Biochem2007，100，5： | 1 |
| 6 | Production and characterization of nanostructured Ti-based intermetallics 显示文摘 | Garibay-Febles V Calderon H A Cabrera A | 2000 | Key Engineering Materials2000，42，2： | 1 |
| 7 | Architecture of the pulmonary veins:relevance to radiofrequency ablation显示文摘 | Ho S Y Cabrera J A Tran V H | | 0，，03： | 1 |
| 8 | Constitutively activated dystrophic muscle fibroblasts show a paradoxical response to TGF-beta and CTGF/CCN2显示文摘 | Mezzano V Cabrera D Vial C | 2007 | J Cell Commun Signal2007，1，34： | 1 |
| 9 | Studies on the zoonotic cycle of Taenia saginata taeniasis and cysticercosis in the Philippines显示文摘 | Arambulo P V Cabrera B D Tongson M S | 1976 | Int J Zoonoses1976，3，： | 1 |
| 10 | Training Practices and Organizational Learning Capability : Relationship and Implica- tions 显示文摘 | Gomez P J Lorente J J C Cabrera R V | 2004 | Journal of European Industrial Training2004，28，23： | 1 |
| 11 | Innate immunity prevents tissue invasion by Entamoeba histolytica显示文摘 | Shibayama M Rivera - Aguilar V Barbosa - Cabrera E | 2008 | Can J Microbiol2008，54，12： | 1 |
| 12 | TIMP-1,-2,-3,and -4 in idiopathic pulmonary fibrosis:a prevailing nondegradative lung microenvironment?显示文摘 | Selman M Ruiz V Cabrera S | 2000 | AJP-Lung Cell Mol Physiol2000，279，3： | 1 |
| 13 | Apoptosis as a possible mechenism of infertility in Echinococcus granulosus cyst 显示文摘 | Paredes R Jimenez V Cabrera G | 2007 | Cell Bioehem2007，100，： | 1 |
| 14 | Anatomic relations between the esophagus and left atrium and relevance for ablation of atrial Fibrillation 显示文摘 | Sanchez-Quintana D Cabrera JA Climent V | 2005 | Circulation2005，112，10： | 1 |
| 15 | The architecture of the left lateral atrial wall:a particular anatomic region with implications for ablation of atrial fibrillation显示文摘 | Cabrera JA Ho SY Climent V | 2008 | Eur Heart J2008，29，： | 1 |
| 16 | A new topological descriptors based model for predicting intestinal epithelial transport of drugs in Caco-2 cell culture 显示文摘 | Marrero Ponce Y Cabrera Perez MA Romero Zaldivar V | 2004 | J Pharm Pharm Sei2004，7，： | 1 |
| 17 | Effect of immediate and delayed post preparation on apical dye leakage using two different sealers显示文摘 | Karapanou V Vera J Cabrera P | 1996 | J Endod1996，22，11： | 1 |
| 18 | Bound aromacompounds of Gual and Listan blanco grape varieties and theirinfluence in the elaborated wines显示文摘 | RODRIGUEZ B CABRERA V P蒖EZ T | 2011 | Food Chemistry2011，127，3： | 1 |
| 19 | Search of the active site in nitrogen-doped carbon nanotube electrodes for the oxygen reduction reaction显示文摘 | Rao C V Cabrera C R IshikawaIn Y | 2010 | Journal of Physical Chemistry Letters2010，1，18： | 1 |
| 20 | Anatomic relations between the esophagus and left atrium and relevance for ablation of atrial fibrillation 显示文摘 | Sancbez-Quintana D Cabrera JA Climent V | 2005 | Circulation2005，112，： | 1 |
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