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| 1 | Acute antibody-mediated rejection after intestinal transplantation显示文摘AIM To investigate the incidence, risk factors and clinical outcomes of acute antibody-mediated rejection(ABMR) after intestinal transplantation(ITx).METHODS A retrospective single-center analysis was performed to identify cases of acute ABMR after ITx, based on the presence of donor-specific antibody(DSA), acute tissue damage, C4 d deposition, and allograft dysfunction.RESULTS Acute ABMR was identified in 18(10.3%) out of 175 intestinal allografts with an average occurrence of 10 d(range, 4-162) after ITx. All acute ABMR cases were presensitized to donor human leukocyte antigens class Ⅰand/or Ⅱ antigens with a detectable DSA. A positive cross-match was seen in 14(77.8%) cases and twelve of 18 patients(66.7%) produced newly-formed DSA following ITx. Histological characteristics of acute ABMR include endothelial C4 d deposits, interstitial hemorrhage, and severe congestion with focal fibrin thrombin in the lamina propria capillaries. Multivariate analysis identified a liver-free graft and high level of panel reactive antibodyas a significant independent risk factor. Despite initial improvement after therapy, eleven recipients(61.1%) lost transplant secondary to rejection. Of those, 9(50%) underwent graft removal and 4(22.2%) received second transplantation following acute ABMR. At an average follow-up of 32.3 mo(range, 13.3-76.4), 8(44.4%) recipients died.CONCLUSION Our results indicate that acute ABMR is an important cause of intestine graft dysfunction, particularly in a liver-exclusive graft and survivors are at an increased risk of developing refractory acute rejection and chronic rejection. More effective strategies to prevent and manage acute ABMR are needed to improve outcomes. | Guo-Sheng Wu Ruy J Cruz Jr Jun-Chao Cai | 2016 | World Journal of Transplantation2016，6，4： | 5 |
| 2 | Hypertrophic adenoids in patients with nasopharyngeal carcinoma:appearance at magnetic resonance imaging before and after treatment显示文摘Introduction:Patients with nasopharyngeal carcinoma(NPC) sporadically develop abnormal adenoids.Nasopharyngeal adenoids are usually included in the gross tumor volume(GTV) but may have different therapeutic responses than tumor tissue.Therefore,distinguishing adenoids from tumor tissue may be required for precise and efficient chemoradiotherapy and radiotherapy.We characterized nasopharyngeal adenoids and investigated the therapeutic responses of NPC and nasopharyngeal adenoids using magnetic resonance imaging(MRI).Methods:MRI data from 40 NPC patients with a coexisting adenoid mass before and after treatment were analyzed.The features of the adenoid masses,including location,striped appearance,size,interface,symmetry/asymmetry,and cysts,were evaluated.Treatment response were scored according to the World Health Organization guidelines.Results:A striped appearance was observed in 36 cases before treatment and in all cases after treatment.In these 36 cases,the average GTVs including and excluding the uninvolved adenoids were 19.8 cm^3 and 14.8 cm^3,respectively.The average percentage change after excluding the uninvolved adenoids from the GTV was 31.0%.Stable disease in the adenoids was identified in 27(96.4%) of 28 patients after neoadjuvant chemotherapy,while NPC clearly regressed.Partial adenoid responses were identified in 33(82.5%) of 40 patients at 3 months after chemoradiotherapy or radiotherapy,whereas complete tumor responses were achieved in all patients.Six months after treatment,the adenoids continued to atrophy but did not disappear,and tumor recurrence was not found.Conclusions:Nasopharyngeal adenoids and carcinoma tissue in NPC patients can be distinguished by using MRI and have different responses to chemoradiotherapy and radiotherapy.These findings contribute to better delineating the GTV of NPC,based on which spatially optimized strategies can be developed to render precise and efficient chemoradiotherapy and radiotherapy.Additionally,we observed a clear difference in the responses of these two tissue types to current therapies.This finding may reduce or avoid unnecessary biopsies or overtreatment. | Yao-Pan Wu Pei-Qiang Cai Li Tian Jie-Hua Xu Richard Alan Mitteer Jr Yi Fan Zhenfeng Zhang | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 3 | Laparoscopically assisted sigmoid colon vaginoplasty in women Mayer-Rokitansky-Kuster- Hauser syndrome: feasibility and short-term results 显示文摘 | Cai B Zhang JR Xi XW | 2007 | BJOG2007，114，： | 1 |
| 4 | Blue light-induced apoptosis of A2Econtaining RPE: involvement of caspase-3 and protection by Bcl-2 显示文摘 | Sparrow JR Cai B | 2001 | Invest Ophthalmol Vis Sci2001，42，6： | 1 |
| 5 | Evaluation of MAGE-1 and MAGE-3 as tumor-specific markers to detect blood dissemination of hepatocellular carcinoma cells显示文摘 | Mou DC Cai SL Peng JR | 2002 | Br J Cancer2002，86，1： | 1 |
| 6 | Cotton leaf curl Multan virus newly reported to be associated with cotton leaf curl disease in China显示文摘 | Cai JH Xie K Lin L Qin BX Chen BS Meng JR Liu Y | | 0，，04： | 1 |
| 7 | IKKbeta/NF-kappaB activation causes severe muscle wasting in mice显示文摘 | CAI D FRANTZ JD TAWA NE JR | 2004 | Cell2004，119，2： | 1 |
| 8 | Protein modification by acrolein: formation and stability of cysteine adducts显示文摘 | CAI J BHATNAGAR A PIERCE W M JR | 2009 | Chem Res Toxicol2009，22，： | 1 |
| 9 | Effect of window reflection on gyrotron operation显示文摘 | AntonsenT M Jr Cai A Y Nosinovich G S | 1992 | Phys Fluids B1992，4，12： | 1 |
| 10 | The cytotoxic activity of ursolic acid derivatives显示文摘 | Ma CM Cai SQ Cui JR | 2005 | European Journal of Medicinal Chemistry2005，40，： | 1 |
| 11 | Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells显示文摘 | Cai D Latham V M Jr Zhang X | 2006 | Cancer Res2006，66，18： | 1 |
| 12 | Improved immunosuppression with combination tacrolimus (FK506) and mycophenolic acid in orthotopic liver transplantation 显示文摘 | Cai TH Esterl RM Jr Nichols L | 1998 | Transplant Proc1998，30，4： | 1 |
| 13 | 1,10-Phenanthroline-FeI+oxidative assay of hydroxyl radical produced by H202/Fe2+显示文摘 | Jin M Cai YX Li JR | 1996 | Prog in Biochem Biophys1996，23，： | 1 |
| 14 | Transforming growth factor-beta receptor binding and function are decreased in psoriatic dermal endothelium显示文摘 | Cai JP Falanga V Taylor JR | | 0，，： | 1 |
| 15 | Involvement of c-Abl, p53 and the MAP kinase JNK in the cell death program initiated in A2E-laden ARPE-19 cells by exposure to blue light 显示文摘 | Westlund BS Cai B Sparrow JR | 2009 | Apoptosis2009，14，： | 1 |
| 16 | Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer 显示文摘 | Long JR Cai QY Sung H | 2012 | PLoS Genet2012，8，10： | 1 |
| 17 | A mouse model fordeveloping treatment for secondary liver tumors显示文摘 | Cai SR Garbow JR Culverhouse R | 2005 | Int J Oncol2005，27，1： | 1 |
| 18 | Evaluation of MAGE-1 and MAGE-3 as tumour-specific markers to detect blood dissemination of hepatocellular carcinoma cells显示文摘 | Mou DC Cai SL Peng JR | 2002 | Br J Cancer2002，86，： | 1 |
| 19 | The cytotoxic activity of ursolic acid derivatives显示文摘 | MA CM CAI SQ CUI JR | 2005 | Eur J Med Chem2005，40，6： | 1 |
| 20 | The cytotoxic activity of ursol- ic acid derivatives显示文摘 | MA CM CAI SQ CUI JR | 2005 | Eur J Med Chem2005，40，6： | 1 |
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