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| 1 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 2 | A spatially explicit test of foraging in a clonal plant显示文摘 | Evans Jonathan P Cain Michael L | 1995 | Ecology1995，76，4： | 1 |
| 3 | The cost of increased animal welfare standards in UK pig production systems 显示文摘 | GUY J H BORNETT H L I CAIN P J | 2003 | Farm Management2003，11，7： | 1 |
| 4 | Optimizing antibody panels for efficient and cost-effective flow cytometric diagnosis of acute leukemia显示文摘 | Haycocks NG Lawrence L Cain JW | 2011 | Cytometry B Clin Cytom2011，80，4： | 1 |
| 5 | Relationship of texture profile analysis and Warner-Bratzler shear force with sensorycharacteristics of beef rib steaks显示文摘 | CAINE W R AALHUS J L BEST D R | 2003 | Meat Science2003，64，4： | 1 |
| 6 | Use the Power of Sonocrystallization for Improved Properties 显示文摘 | McCausland L J Cains P W MartnL P D | 2001 | Chemical Engineer- ing Progress2001，97，7： | 1 |
| 7 | Induction of Ovulationin Bitches Using SubcutaneousInjiection of GnRH Analog 显示文摘 | Cain J L | 1989 | Animal Breeding1989，58，3： | 1 |
| 8 | Psychophysical and physiological comparison of squat and semi-squat lifting by young males 显示文摘 | STRAKER L CAIN C | 2000 | Occupational Ergonomics2000，2，1： | 1 |
| 9 | A spatially explicit test of foraging behavior in a clone plant显示文摘 | Evans J P Cain M L | 1995 | Ecology1995，76，： | 1 |
| 10 | Anticario- genicity of calcium phosphate complexes of tryptic casein phosphopeptides in the rats显示文摘 | Reynolds E C Cain C J Webber E L | 1995 | Journal of Dental Research1995，74，6： | 1 |
| 11 | Pretreatment of soybean meal with phytase for salmonoid diets to reduce phosphorus concentrations in hatchery effluents显示文摘 | Cain K D Garling D L | 1995 | Progressive Fish-Culturist1995，57，： | 1 |
| 12 | Characterisation of mucosal and systemic immune responses in rainbow trout (Oncorhynchus mykiss) using surface plasmon resonance显示文摘 | Cain K D Jones D R Raison R L | 2000 | Fish & Shellfish lmmunol2000，10，8： | 1 |
| 13 | Characterisation of mucosal and systemic immune responses in rainbow trout(Oncorhynchus mykiss)using surface plasmon resonance显示文摘 | Cain K D Jones D R Raison R L | 2000 | Fish and Shellfish Immunology2000，10，8： | 1 |
| 14 | Effect of fibu- lar plate fixation on rotational stability of simulated distal tibial fractures treated with intramedullary nailing 显示文摘 | KUMAR A CHARLEBOtS S J CAIN E L | 2003 | J Bone Joint Surg Am2003，85，4： | 1 |
| 15 | Relationship of texture profile analysis and Warner-Bratzler shear force with sensory characteristics of beef rib steaks显示文摘 | Caine W R Aalhus J L Best D R Dugan M E R Jeremiah L E | 2003 | Meat Science2003，64，： | 1 |
| 16 | Gender differ- ences in gastrointestinal, psychological, and somatic symptoms in irritable bowel syndrome 显示文摘 | Cain K C Jarrett M E Burr R L | 2009 | Dig Dis Sci2009，54，7： | 1 |
| 17 | Residual Strength Pre-diction of Composite Materials: Random Spectrum Loading显示文摘 | POST N L CAIN J MCDONALD K J | 2008 | Engineering Fracture Mechanics2008，，62： | 1 |
| 18 | Evidence of aliphatics in nascent soot particles in premixed ethylene flames显示文摘 | Cain J P Gassman P L Wang H | 2011 | Proceedings of the Combustion Institute2011，33，1： | 1 |
| 19 | Pretreatment of soybean meal with phytase for salmonid diets to reduce phos- phorus concentrations in hatchery effluents 显示文摘 | CAIN K D GARLING D L | 1995 | The Progressive Fish-Culturist1995，57，： | 1 |
| 20 | A spatial explicit test of foraging behavior in a clonal plant 显示文摘 | EVANS J P CAIN M L | 1995 | Ecology1995，76，1： | 1 |
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