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| 1 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 2 | Misdiagnosis of tuberculosis and the clinical relevance of nontuberculous mycobacteria in Zambia显示文摘Objective:To determine the accuracy of TB diagnosis of TB in Zambia in the era of increasing HIV prevalence.Methods:Sputum of the clinically diagnosed TB cases was additionally subjected to liquid culture and molecular identification.This study distinguished between TB cases confirmed by positive Mycobacterium tuberculosis(M.tuberculosis) cultures and mycobacterial disease caused by non-tuberculous mycobacteria(NTM).Results:Only 49% of the 173 presumptively diagnosed TB cases was M.tuberculosis cultured,while in 13% (22) cases,a combination of M.tuberculosis and NTM was found.In 18% of the patients only NTM were cultured.In 28% ,no mycobacteria was cultivable.HIV positive status was correlated with the isolation of NTM(P<0.05).Conclusions:The diagnosis of tuberculosis based on symptoms, sputum smear and/or chest X-ray leads to significant numbers of false-positive TB cases in Zambia,most likely due to the increased prevalence of HIV.The role of NTM in tuberculosislike disease also seems relevant to the false diagnosis of TB in Zambia. | Patricia CAM Buijtels Michael D Iseman Shelagh Parkinson Cas S de Graaff Henri A Verbrugh Pieter LC Petit Dick van Soolingen | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，5： | 2 |
| 3 | High power diode laser va-porization of the prostate: preliminary results for benignprostatic hyperplasia显示文摘 | Erol A Cam K Tekin A | 2009 | J Urol2009，182，3： | 1 |
| 4 | Speciation analysis of selenium compoundsin yeasts using pressurized liquid extraction and liquid chromatography- microwave-assisted digestion-hydride genera-tion-atomic fluorescence spectrometry 显示文摘 | Gomez-Ariza J L Cam De La Torre M A Giraldez I | 2004 | Anal Chim Acta2004，524，12： | 1 |
| 5 | Association between the eNOS (Glu298Asp) and the RAS genes polymorphisms and premature coronary artery disease in a Turkish population 显示文摘 | Berdeli A Sekuri C Cam ST | 2005 | Clin Chim Acta2005，351，12： | 1 |
| 6 | Variation in pathogenicity and DNA polymorphism among Botrytis cinerea isolates sampled inside and outside a glasshouse显示文摘 | KERSSIES A BOSKER-VAN ZESSEN I WAGEMAKERS CAM | 1997 | Plant Disease1997，81，7： | 1 |
| 7 | Relation Between Clinical Pulmonary Infection Score,C-Reactive Protein,and Procalcitonin and Mortality in Patients With Hospital Acquired Pneumonia显示文摘 | Havlucu Y Coskun A Cam S | 2012 | Chest2012，142，4： | 1 |
| 8 | Discrepancy of pre-and postoperative grades of patients with endometrial carcinoma显示文摘 | Karateke A Tug N Cam C | 2011 | Eur J Gynaecol Oncol2011，32，3： | 1 |
| 9 | Six hundred fifty consecutive pancreatico- duoden cctom ie s in the 1990s 显示文摘 | Yeo C J Cam cron J L Sohn T A | 1977 | Ann Surg1977，226，3： | 1 |
| 10 | High power diode laser vaporization of the prostate:preliminary results for benign prostatic hyperplasia 显示文摘 | Erol A Cam K Tekin A | 2009 | J Urol2009，182，3： | 1 |
| 11 | Body measurements reflect body weights and carcass yields in karayaka sheep显示文摘 | Cam M A Olfaz M Soydan E | 2010 | Asian Journal of Animal and Veterinary Advances2010，5，2： | 1 |
| 12 | Break through Volumes increased by the assition of salt in the on - line solid - phase extraction and liquid chromatography of pesticides in environ - mental water 显示文摘 | Martin - Esteban A Fernandez P Cam atra C | | intern J Environ Ana]ytica Chemica Acta0，，： | 1 |
| 13 | RcsF is an outer membrane lipoprotein involved in the RcsCDB phosphorelay signaling pathway in Escherichia coli显示文摘 | CASTANIE-CORNET M P CAM K JACQ A | 2006 | J Bacteriol2006，188，12： | 1 |
| 14 | Intron F G79A poly- morphism of the protein Z gene in cancer patients with and without thrombosis显示文摘 | Eroglu A Ozturk A Cam R | 2009 | J Thromb Thrombolysis2009，27，2： | 1 |
| 15 | Levofloxaein/ amoxicillin- based schemes vs quadruple therapy for He- licobacter pylori eradication in second - line 显示文摘 | Di Cam S1 Fini L Daoud Y Grizzi F Gasbzini A De Lorenzo A Di Renzo L McCamaey S Bloom S | 2012 | World J Gastroenterol2012，18，40： | 1 |
| 16 | Experimental a- nalysis of prepreg tack显示文摘 | Dubois O Le Cam J B Beakou A | 2010 | Experimental Mechanics2010，50，5： | 1 |
| 17 | Body Measurements reflect body weights and carcass yields in Karayaka sheep 显示文摘 | Cam M A Olfaz M Soydan E | 2010 | Asian Journal of Animal and Veterinary Advances2010，5，2： | 1 |
| 18 | Effect of monocyte chemoattrac- tam protein - 1 ( MCP - 1 ) gene polymorphism in Turkish patients with premature coronary artery disease 显示文摘 | Cam SF Sekuri C Sagcan A | 2008 | Scand J Clin Lab Invest2008，68，8： | 1 |
| 19 | High power diode laser vaporization of the prostate:preliminary results for benign prostatic hyperplasia显示文摘 | Erol A Cam K Tekin A | 2009 | J Urol2009，182，3： | 1 |
| 20 | Mild hypoglycaemic at acks induced by sulphonylureas related to CYP2C9,CYP2C19 and CYP2C8 polymorphisms in routine clinical set ing显示文摘 | Gokalp O Gunes A Cam H | | 0，，12： | 1 |
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