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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | Evaluation and treatment of internal impingement of the shoulder in overhead athletes显示文摘One of the most common pathologic processes seen in overhead throwing athletes is posterior shoulderpain resulting from internal impingement. 'Internal impingement' is a term used to describe a constellation of symptoms which result from the greater tuberosity of the humerus and the articular surface of the rotator cuff abutting the posterosuperior glenoid when the shoulder is in an abducted and externally rotated position. The pathophysiology in symptomatic internal impingement is multifactorial,involving physiologic shoulder remodeling,posterior capsular contracture,and scapular dyskinesis. Throwers with internal impingement may complain of shoulder stiffness or the need for a prolonged warm-up,decline in performance,or posterior shoulder pain. On physical examination,patients will demonstrate limited internal rotation and posterior shoulder pain with a posterior impingement test. Common imaging findings include the classic 'Bennett lesion' on radiographs,as well as articular-sided partial rotator cuff tears and concomitant SLAP lesions. Mainstays of treatment include intense non-operative management focusing on rest and stretching protocols focusing on the posterior capsule. Operative management is variable depending on the exact pathology,but largely consists of rotator cuff debridement. Outcomes of operative treatment have been mixed,therefore intense non-operative treatment should remain the focus of treatment. | Keith T Corpus Christopher L Camp David M Dines David W Altchek Joshua S Dines | 2016 | World Journal of Orthopedics2016，7，12： | 2 |
| 3 | Wideband radar for ballistic missile defense and range-Doppler imaging of satellites 显示文摘 | Camp W W Mayhan J T O' Donnell R M | 2000 | The Lincoln Laboratory Journal2000，12，2： | 1 |
| 4 | A role for XRCC2gene polymorphisms in breast cancer risk and survival显示文摘 | Lin W Y Camp N J Cannon-Albright L A | 2011 | J Med Genet2011，48，7： | 1 |
| 5 | Vascular endothelial growth factor receptor-1 activation mediates to mesenchymal transition in human pancreatic carcinoma cells 显示文摘 | Yang AD Camp ER Jiang W | 2006 | Cancer Res2006，66，1： | 1 |
| 6 | Stationary Distributions for the Random Waypoint Mobility Model显示文摘 | Navidi W Camp T | 2004 | IEEE Transactions on Mobile Computing2004，3，1： | 1 |
| 7 | ()zone, sulfur dioxide, and ultraviolet have similar effects on mRNA ac cumulation of antioxidant genes in Nicotiana plumbagimfolia L显示文摘 | Willekens H Van Camp W Van Montagu M | 1994 | Plant Physiology1994，，106： | 1 |
| 8 | Differential regulation of superoxided ismutases in plants exposed to nvironm ental stress显示文摘 | TSANG ED WTBC HEROUART D VAN CAMP W | 1991 | Plant Cell1991，，3： | 1 |
| 9 | Changes in submersed aquatic vegetation affect predation risk of a common prey fish Lucania parva (Cyprinodontiformes: Fundulidae) in a spring-fed coastal river显示文摘 | Camp E V Gwinn D C Pine Iii W E Frazer T K | 2012 | Fisheries Management & Ecology2012，19，3： | 1 |
| 10 | Subsurface damage and polishing compound affect the 355 nm laser damage threshold of fusedsilica surfaces显示文摘 | Camp D W Kozlowski M R Sheehan L M | 1998 | Proceedings of SPIE1998，3244，： | 1 |
| 11 | Halo application in the infant显示文摘 | Mubarak SJ Camp JF Vuletich W | 1989 | J Pediatr Orthop1989，9，5： | 1 |
| 12 | Fact ors affecting the enhancement of oxidative stress tolerance in transgenic tobacc o overexpressing manganese superoxide dismutase in the chloroplasts显示文摘 | Capiau K Camp W V Montagu M V Sybesma C and Inzé D | 1995 | Plant P hysiol1995，107，： | 1 |
| 13 | Wideband radar for ballistic missile defense and range-doppler imaging of satellites显示文摘 | Mayhan J T Donnell R M | 2000 | Lincoln Laboratory Journal2000，12，2： | 1 |
| 14 | Biocontrol of the food-borne pathogens Listeria monocytogenes and Salmonella enterica serovar Poona on fresh-cut apples with naturally occurring bacterial and yeast antagonists显示文摘 | Leverentz B Conway WS Janisiewiez W Abadias M Kurtzman CP Camp MJ | 2006 | Applied and Environmental Microbiology2006，72，2： | 1 |
| 15 | Superoxide dismutase in plants显示文摘 | Bowler C Van Camp W Van Montagu M Inzéd | 1994 | Critical Reviews in Plant Science1994，13，3： | 1 |
| 16 | H202 and NO: redox signals in disease resistance 显示文摘 | van Camp W van Montagu M Inzé D | 1998 | Trends Plant Sci1998，3，： | 1 |
| 17 | Constructivism:the Career and Technical Education Perspective显示文摘 | Doolittle P E Camp W G | 1999 | Jom''nal of Vocation and Technical Education1999，，： | 1 |
| 18 | Enhancement of o xidative stress tolerance in transgenic tobacco plants overproduction Fe-superox ide dismutase in chloroplasts显示文摘 | Capiau K Montagu M V Inzé D Slooten L | 1996 | Plant Physiol1996，112，： | 1 |
| 19 | Hie use of high pressure to modify the functionality of food proteins显示文摘 | MESSENS W VAN CAMP J HUYGHE3AEBT A | 1997 | Holds in Food Sci & Texh1997，8，： | 1 |
| 20 | H2O2 and NO: redox signals in disease resistance 显示文摘 | Van Camp W Van Montagu M Inze D | 1998 | Trends in Plant Science1998，3，： | 1 |
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