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| 1 | Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal metastases显示文摘AIM:To systematically review the available evidence regarding cytoreductive surgery(CRS) and intraperitoneal chemotherapy(IPC) for colorectal peritoneal metastases(CPM).METHODS:An electronic literature search was carried out to identify publications reporting oncological outcome data(overall survival and/or disease free survival and/or recurrence rates)following CRS and IPC for treatment of CPM.Studies reporting outcomes following CRS and IPC for cancer subtypes other than colorectal were only included if data were reported independently for colorectal cancer-associated cases;in addition studies reporting outcomes for peritoneal carcinomatosis of appendiceal origin were excluded.RESULTS:Twenty seven studies,published between1999 and 2013 with a combined population of 2838patients met the predefined inclusion criteria.Included studies comprised 21 case series,5 case-control studies and 1 randomised controlled trial.Four studies provided comparative oncological outcome data for patients undergoing CRS in combination with IPC vs systemic chemotherapy alone.The primary indication for treatment was CPM in 96%of cases(2714/2838)and recurrent CPM(rCPM)in the remaining 4%(124/2838).In the majority of included studies(20/27)CRS was combined with hyperthermic intraperitoneal chemotherapy(HIPEC).In 3 studies HIPEC was used in combination with early post-operative intraperitoneal chemotherapy(EPIC),and 2 studies used EPIC only,following CRS.Two studies evaluated comparative outcomes with CRS+HIPEC vs CRS+EPIC for treatment of CPM.The delivery of IPC was performed using an'open'or'closed'abdomen approach in the included studies.CONCLUSION:The available evidence presented in this review indicates that enhanced survival times can be achieved for CPM after combined treatment with CRS and IPC. | Reza Mirnezami Brendan J Moran Kate Harvey Tom Cecil Kandiah Chandrakumaran Norman Carr Faheez Mohamed Alexander H Mirnezami | 2014 | World Journal of Gastroenterology2014，20，38： | 6 |
| 2 | 通过业余时间运动的中老年的运动心电图:100次运动试验足以确定一个无症状心肌缺血的心脏事件风险显示文摘运动心电图在预防运动员心脏事件方面的重要性一直存在争议。为了确定运动心电图中无症状心肌缺血(silent myocardial ischemia,SMI)的频率及运动心电图与冠状动脉造影评估结果和潜在可预防的心脏事件的关系。Hupin等纳入2011-2014年就诊于Saint-Etienne大学医院运动医学科年龄≥35岁的无症状业余运动员,进行前瞻性队列研究。 | 刘青 叶鹏 Hupin D Edouard P Oriol M Laukkanen J Abraham P Doutreleau S Guy JM CarréF Barthélémy JC Roche F Chatard JC | 2018 | 中华高血压杂志2018，26，4： | 6 |
| 3 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 4 | Temperature dependence of intramolecular dynamics of the basic leu cine zipper of GCN4: Implications for the entropy of association with DNA显示文摘 | Bracken C Carr P A Cavanagh J | 1999 | J Mol Biol1999，285，5： | 1 |
| 5 | Questionnaire on the perceptions of patients about shoulder surgery显示文摘 | Fitzpatrick R Carr A | 1996 | J Bone Joint Surg(Br)1996，78，： | 1 |
| 6 | Pathophysiology of spinal injury recovery after immediate and delayed decompression显示文摘 | SHERMAN J CARR J B | 1998 | J Bone Joint Surg1998，77，8： | 1 |
| 7 | A shared eleetrnnie health record: lessons from the coalfaee显示文摘 | Carr Simon J | 2009 | The Medical journal of Australia2009，190，11： | 1 |
| 8 | Ovarian granulosa cell lines显示文摘 | Havelock J C Rainey W E Carr B R | 2004 | Mol Cell Endocrinol2004，228，12： | 1 |
| 9 | Polyamines and related enzymesin rice seeds differing in germination potential显示文摘 | BONNEAU L CARRE M TANGUY J M | 1994 | Plant Growth Regula-tion1994，15，： | 1 |
| 10 | Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk显示文摘 | CARR M C BRUNZELL J D | 2004 | J Clin Endocrinol Metab2004，89，6： | 1 |
| 11 | Identification ofa gene expression profile that discriminates indirect - acting genotoxins from direct - acting genotoxins 显示文摘 | HU T GIBSON D P CARR G J | 2004 | Murat Res2004，549，： | 1 |
| 12 | Goals, Feedback, and Self-regulation:Control Theory as a Natural Framework for Executive Coaching 显示文摘 | GREGORY J B BECK J W CARR A E | 2011 | Consulting Psychology Journal : Practice & Research2011，63，1： | 1 |
| 13 | Correlation of the diame- ter of the left common iliae vein with the risk of lower-ex- tremity deep venous thrombosis 显示文摘 | Carr S Chart K Rosenberg J | 2012 | Vasc Interv Radiol2012，23，11： | 1 |
| 14 | Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resistance显示文摘 | JACKSON C J LIU J W CARR P D | 2013 | Proceedings of the National Academy of Sciences2013，110，10： | 1 |
| 15 | Insights and new direc- tions from demand-side approaches to technology inno- vation, entrepreneurship, and strategic management re- search显示文摘 | Priem R L Li S Carr J C | 2012 | Journal of Management2012，38，1： | 1 |
| 16 | The Photoassisted Reaction of Gaseous Water and Carbon Dioxide Adsorbed on the SrTiO 3 (Ⅲ)Crystal Face to Form Methane显示文摘 | Hemminger J C Carr R Somorjai G A | 1978 | Chem Phys Lett1978，57，1： | 1 |
| 17 | Liver transplantation and chemotherapy for hepatoblastoma and hepatocellu- lar cancer in childhood and adolescence显示文摘 | Reyes J D Carr B Dvorchik I | 2000 | J Pediatr2000，136，： | 1 |
| 18 | Doing competencies well:best practics in competency modeling显示文摘 | Michael A Campion Alexis A Fink Brian J Ruggeberg Linda Carr Geneva M Phillips Ronald B Odman | 2011 | Personnel Psychology2011，，22： | 1 |
| 19 | The assessment of shoulder instability:the development and validation of a questionnaire显示文摘 | Fitzpatrick R Carr A | 1999 | J Bone Joint Surg(Br)1999，81，： | 1 |
| 20 | The behavior of bearings used for seismic isolation under shear and axial load 显示文摘 | P J Moss N Cook A J Carr | 1999 | Earthquake Spectra1999，15，2： | 1 |
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