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221篇 您的检索式：作者名="Carson J A"

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	题名	作者	年代	出处	被引量
1	Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF.	Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz	2012	Hepatobiliary & Pancreatic Diseases International2012，11，4：	3
2	Particle sizing using passive ultrasonic measurement of particle-wall impact vibrations显示文摘	Carson G Mulholland A J Nordon A	2008	Journal of Sound and Vibration2008，317，12：	1
3	Uncertainty,Opportunism and Governance:The Effects of Volatility and Ambiguity on Formal and Relational Contracting显示文摘	CARSON S J MADHOK A WU T	2006	Academy of Management Journal2006，49，5：	1
4	The evidence for dietary prevention and treatment of cardiovascular disease 显示文摘	van Horn L McCoin M Kris-Etherton P M Burke F Carson J A S Champagne C M	2008	Journal of the American Dietetic Association2008，108，：	1
5	A multilevel investigation of antecedents and consequences of team member boundary-spanning behavior显示文摘	Marrone J A Tesluk P E Carson J B	2007	Academy of Management Journal2007，50，6：	1
6	A Multilevel Investigation of Antecedents and Conse- quences of Team Member Boundary-Spanning Behav- ior显示文摘	MARRONE J A TESLUK P E CARSON J B	2007	Academy of Management Journal2007，50，6：	1
7	Bin loads-Part 2: concepts 显示文摘	A W Jenike J R Johanson and J W Carson	1973	Journal of Engineering for Industry1973，，：	1
8	Late-onset chronic inflammatory encephalopathy in immune competent and severe combined-immune deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor显示文摘	Stalder AK Carson M J Pagenstecher A at el	1998	AmJ Pathol1998，153，3：	1
9	Shared leadership in teams= An investigation of anteeedent conditions and per- formance显示文摘	Carson J B Tesluk P E and Marrone J A	2007	Academy of Management Journal2007，50，5：	1
10	Atrial fibrillation in pregnancy associated with oral terbutaline显示文摘	Carson M P Fisher A J Scorza W E	2002	Obstet Gynecol2002，100，5：	1
11	Quasiperiodie trasition to chaos of instabilities in an electron-hole plasma excited by as perturbations at one and at two frequencies 显示文摘	Held G A Carson J	1986	Phys Rev Lett1986，56，11：	1
12	En- hancing Community-Based Disaster Preparedness with Information Technology 显示文摘	TROY D A CARSON A VANDERBEEK J	2008	Disastesr2008，，1：	1
13	Shared leadership in teams:an investigation of antecedent conditions and performance显示文摘	CARSON J B TESLUK P E MARRONE J A	2007	Academy of Management Journal2007，50，5：	1
14	Uncertainty, opportunism and governance : the effects of volatility and ambigu- ity on formal and relational contracting显示文摘	Carson S J Madhok A Wu T	2006	Academy of Management Journal2006，49，：	1
15	Tolerance of Pseudomonas aeruginosa to Melaleuca alternifolia (tea tree) oilis associated with the outer membrane and energydependent cellular processes显示文摘	Longbottom C J Carson C F Hammer K A	2004	J Antimicrob Chemother2004，54，2：	1
16	A multi-level investigation of antecedents and consequences of team member boundary spanning behavior显示文摘	MARRONE J A TESLUK P E CARSON J B	2007	Academy of Management Journal2007，50，6：	1
17	Extraintestinal dissemination of Salmonella by CD18- ex- pressing phagocytes 显示文摘	Vazquez- Torres A Jones- Carson J Bgumler A J	1999	Nature1999，401，：	1
18	The effect of gastric bypass surgery on hypertension in morbidlyobese patients 显示文摘	Carson J L Ruddy M E Duff A E	2004	Arch Intern Med2004，154，2：	1
19	MIKE 3 versus HARTMANN apparatus:Comparison of measured minimum ignition energy (MIE)显示文摘	Janes A Chaineaux J Carson D	2008	Journal of Hazardous Materials2008，152，1：	1
20	Standardization of a broth microdilution susceptibility testing method to determine minimum inhibitory concentrations of aquatic bacteria 显示文摘	MILLER R A WALKER R D CARSON J	2005	Diseases of Aquatic Organisms2005，64，：	1

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